FASEB SRC on Polycystic Kidney Disease: Challenges, differing viewpoints and ways forward

FASEB SRC 关于多囊肾病：挑战、不同观点和前进方向

• 批准号: 9330725
• 负责人: Vicente E Torres
• 金额: $ 1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9330725
• 关键词: Address; Adult; Affect; Animal Model; Applications Grants; Area; Attention; Autosomal Dominant Polycystic Kidney; Autosomal Recessive Polycystic Kidney; Biochemistry; Biological Markers; Biological Models; Calcium; Canada; Cellular Metabolic Process; Cellular biology; Childhood; Cilia; Clinical; Clinical Investigator; Clinical Trials; Collaborations; Cyclic AMP; Cystic Kidney Diseases; Development; Developmental Biology; Discipline; Disease; Drug Approval; Drug Industry; End stage renal failure; Epigenetic Process; Ethnic group; European Union; Fostering; Functional disorder; Gastroenterology; Genes; Genetic; Genomics; Goals; Health Sciences; Hepatology; Hypertension; Individual; Inherited; Interdisciplinary Study; Japan; Kidney; Kidney Diseases; Knowledge; Korea; Learning; Mendelian disorder; MicroRNAs; Molecular; Molecular Biology; Montana; Mutate; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrology; Organ; Pathway interactions; Patients; Pharmacology; Pharmacotherapy; Phase III Clinical Trials; Physiology; Polycystic Kidney Diseases; Proteins; Public Health; Published Comment; Research; Research Personnel; Science; Scientist; Series; Signal Transduction; Switzerland; Syndrome; Systems Biology; Tissues; Translational Research; Underrepresented Minority; Update; Woman; bench to bedside; ciliopathy; disability; disease-causing mutation; extracellular vesicles; genome editing; improved; interest; lectures; meetings; metabolomics; next generation; novel therapeutics; polycystic liver disease; preclinical trial; prevent; programs; structural biology; symposium; therapeutic target

Project Summary The purpose of this grant application is to provide partial support for the sixth FASEB Science Research Conference on Polycystic Kidney Disease (PKD), “Polycystic Kidney Disease: Challenges, differing viewpoints and ways forward” to take place from June 25 to June 30, 2017, in Big Sky, Montana. The scientific theme of this conference encompasses the inherited renal cystic diseases, including the autosomal dominant (ADPKD) and recessive (ARPKD) forms of PKD, the autosomal dominant polycystic liver diseases with milder involvement of the kidneys (ADPLD) and many syndromic forms of PKD caused by mutations in genes encoding for proteins in the primary cilium (ciliopathies). The conference will bring together investigators from a wide range of different research areas sharing an interest on PKD and other renal cystic diseases and ciliopathies, and will promote cross disciplinary discussion and collaboration. Areas of particular interest will range from basic to translational research with a thematic approach that includes: 1) Genetic mechanisms; 2) Cell biology of PKD proteins, extracellular vesicles and cilia; 3) Epigenetics and microRNAs; 4) Cilia, calcium, and cAMP signaling; 5) Other pathways and model systems; 6) Disease mechanisms in other tissues and organs; 7) Cell metabolism and metabolomics; and 8) Biomarkers and clinical trials. Particular attention in the organization of this Conference has been and will be to including new speakers and speakers from related fields to broaden the knowledge of PKD investigators, to promoting young investigators and fostering their network building with established investigators, and to supporting participation of woman scientists, individuals from underrepresented minorities as well as researchers with disabilities. The range of disciplines attracted to this Conference is wide, including nephrology and hypertension (adult and pediatric), gastroenterology and hepatology, genetics, cell and molecular biology, developmental biology, physiology, biochemistry and structural biology, pharmacology and health sciences. The specific goals of this meeting are: 1) Assemble an interdisciplinary program of basic scientists and clinical researchers that are at the forefront of PKD research to provide a comprehensive update on recent advances in PKD; 2) Provide a format where trainees and junior investigators can present, discuss and learn, with the goal of exciting them about PKD and inspiring them to become the next generation of PKD researchers; 3) Generate a platform for informed discussion to help resolve unanswered questions in PKD, and to promote collaboration; and 4) Promote the development of novel therapies for PKD by juxtaposing basic scientists, clinical investigators and representations of the pharmaceutical industry.

项目概要 本次拨款申请的目的是为第六次 FASEB 科学研究提供部分支持 多囊肾病 (PKD) 会议，“多囊肾病：挑战，不同观点 和前进之路”将于 2017 年 6 月 25 日至 30 日在蒙大拿州 Big Sky 举行。 本次会议涵盖遗传性肾囊性疾病，包括常染色体显性遗传病（ADPKD） 和隐性 (ARPKD) 形式的 PKD，常染色体显性多囊肝病，病情较轻 肾脏受累 (ADPLD) 和由基因突变引起的多种 PKD 综合征形式 初级纤毛中蛋白质的编码（纤毛病）将汇集来自不同领域的研究人员。 广泛的不同研究领域对 PKD 和其他肾囊性疾病都有共同的兴趣 纤毛病，并将促进特别感兴趣的领域的跨学科讨论和合作。 从基础研究到转化研究，采用主题方法，包括：1) 遗传机制；2) PKD 蛋白、细胞外囊泡和纤毛的细胞生物学；3) 表观遗传学和 microRNA；4) 纤毛、钙、 和 cAMP 信号传导；5) 其他途径和模型系统；6) 其他组织和疾病机制； 器官；7）细胞代谢和代谢组学；8）生物标志物和临床试验。 本次会议的组织已经并将包括新的发言人和来自相关领域的发言人 拓宽 PKD 调查人员的知识、提升年轻调查人员并培养他们的能力 与现有研究人员建立网络，并支持女科学家、个人的参与 来自代表性不足的少数群体以及残疾研究人员。 本次会议内容广泛，包括肾脏病学和高血压（成人和儿童）、胃肠病学和 肝病学、遗传学、细胞和分子生物学、发育生物学、生理学、生物化学和 本次会议的具体目标是： 1) 组建一个结构生物学、药理学和健康科学领域的机构。 由处于 PKD 研究前沿的基础科学家和临床研究人员组成的跨学科项目 提供有关 PKD 最新进展的全面更新； 2) 提供一种格式，供学员和初级人员使用 研究人员可以展示、讨论和学习，目的是激发他们对 PKD 的兴趣并激励他们 成为下一代 PKD 研究人员；3) 建立一个知情讨论平台，以提供帮助 解决PKD中未解答的问题，并促进合作；4）促进新颖的发展； 通过并列基础科学家、临床研究人员和代表来治疗 PKD 制药业。