National Center/Emerging Infectous Diseases & Biodefense

国家中心/新发传染病

• 批准号: 6712139
• 负责人: Mark S Klempner
• 金额: $ 12802.12万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6712139
• 关键词: National; Center; Emerging; Infectous; Diseases

SUMMARY OF OBJECTIVES: Boston University Medical Center (BUMC), a consortium of Boston University and Boston Medical Center, proposes a National Center for Emerging Infectious Diseases and Biodefense (NCEIDB). The primary objectives are: 1) To construct a safe, secure facility for cutting-edge basic, translational, animal and clinical research on emerging infectious diseases including category A, B and C agents integrated into the research and emergency-preparedness environments of BUMC, Boston, and the nation 2) To put into place comprehensive research, development and training programs to achieve the objectives of the NIAID's Strategic Plan for Biodefense Research. The NCEIDB incorporates 18 intramural core resources and expertise for basic molecular studies aimed at identifying target molecules, identifying small molecules and biologicals that interact with these molecules for diagnostic, preventative or therapeutic purposes, a plan for producing such products, facilites for assessment of the interaction of pathogens with these molecules in vitro, and a comprehensive approach for evaluations in vivo in animals and humans. The proposed NCEIDB is responsive to all of the required elements and is distinguished by unique features including: integration of the facility into a biomedical "research park", an aggressive time-line for project completion, integration with a premier urban academic medical center, coordination with the New England Regional Primate Research Center to build dedicated non-human primate breeding and quarantine facilities, coordination with the Massachusetts Biological Laboratories for production of vaccines and biologicals under GMP conditions, coordination with unique resource to produce chemical libraries and extensive planning for the training mission of the NCEIDB.

目标摘要：波士顿大学医学中心（BUMC），波士顿大学和波士顿医学中心的财团，提议了一个国家新兴的传染病和生物疾病中心（NCEIDB）。主要目标是：1）建造一个安全，安全的设施，以针对新兴的传染病，包括A类，B和C代理（包括A，B和C类代理）的尖端基本，转化，动物和临床研究，并将其整合到BUMC，BOSTON和NATER的研究和紧急准备环境中，以实现全面的研究，开发和培训计划的目标，以实现全面的研究，开发和培训程序。 NIAID的生物化研究战略计划。 NCEIDB纳入了18种旨在识别靶分子的基本分子研究的壁内资源和专业知识，识别与这些分子相互作用的小分子和生物学，以诊断，预防性或治疗目的，一种计划，用于生产此类产品的计划，以评估这些分子的相互作用，以评估这些分子的相互作用。拟议的NCEIDB对所有必需的元素都有响应，并以独特的特征为由，包括：集成 建立生物医学“研究公园”的设施，即项目完成的积极时间，与主要的城市学术医学中心融为一体，与新英格兰地区的新英格兰地区灵长类动物研究中心协调，以建立专门的非人类灵长类动物的设施，并与Massachusetts生产的疫苗和生物生物生产的生产计划，共同生产的非人类灵长类设施，并协调，以供疫苗和生物生产，摄于疫苗和生物的生产，摄于生物的生物，摄于生物，摄于生物的生物。 NCEIDB的培训任务。