UofL RBL Operations, Workforce Development and Pandemic Preparedness Research

伦敦大学 RBL 运营、劳动力发展和流行病防范研究

• 批准号: 10793918
• 负责人: KENNETH E PALMER
• 金额: $ 293.57万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793918
• 关键词: Attention; Biological Warfare; Biomedical Research; Biotechnology; COVID-19; COVID-19 pandemic; COVID-19 patient; China; Clinical Trials; Communities; Containment; Creativeness; Crowns; Dedications; Diagnostic; Disease Outbreaks; Economics; Emerging Communicable Diseases; Ensure; Federal Government; Funding Opportunities; Future; Goals; Health Services Research; Health care facility; Hospitals; Hour; Human Resources; Industry; Infection; Institution; International; Investigational New Drug Application; Kentucky; Laboratories; Leadership; Learning; Maintenance; Managed Care; Medicine; Mentors; Mission; Modeling; National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Nose; Patients; Philosophy; Play; Public Health; Research; Research Personnel; Research Support; Resources; Rest; Reverse Transcriptase Polymerase Chain Reaction; Risk; Role; Scientist; Serology test; Services; System; Talents; Techniques; Testing; Therapeutic; Training; Translational Research; United States National Institutes of Health; Universities; University resources; Vaccines; Work; Workforce Development; biocontainment facility; biodefense; biothreat; cohort; emergency preparedness; experience; improved; laboratory experience; medical countermeasure; metropolitan; novel; novel coronavirus; operation; pandemic disease; pandemic preparedness; pandemic response; pathogen; previous pandemic; prognostic; prophylactic; public health emergency; recruit; response; service organization; skills; wastewater surveillance

SUMMARY (OVERALL): The University of Louisville Regional Biocontainment Laboratory (RBL) is operated by the University Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases (CPM). The RBL is a regional resource that facilitates translational research to develop diagnostics, prognostics, therapeutics and vaccines to mitigate biodefense and emerging infectious disease threats. Our Center operates the only BSL-3 and ABSL-3 facilities currently operating in the Commonwealth of Kentucky. The CPM mandate is to prepare for and respond to public health emergencies, such as the COVID-19 pandemic. The broad, long-range objectives and goals of the University of Louisville (UofL) CPM RBL are: 1. To offer state-of-the-art research services to the regional and national biomedical research community to learn from past pandemics and biological warfare experiences and effectively predict and mitigate future emerging infectious disease threats. 2. To manage, maintain and operate the UofL RBL to serve the national and regional need for biocontainment facilities suitable for research on Risk Group 3 pathogens and other biothreats. 3. To follow a philosophy of continuous improvement in BSL-3 and ABSL-3 work practices and to ensure that all personnel who need to access BSL-3 and ABSL-3 containment laboratories are appropriately trained and prepared to serve the national and regional need for biocontainment research professionals. To achieve these aims we propose to establish three collaborative Cores. The Facilities Management Maintenance and Operations Core (FMMO Core) is responsible for ensuring that the facility is always available to meet the research and emergency preparedness mission of the RBL. The BSL-3 Practices and Workforce Development Core (BSL-3PWD Core) formalizes our mentor-mentee training plan to ensure our laboratory is staffed with BSL-3 research professionals who are proficient at biocontainment research professionals. This core responds to the reality that response to rapidly emerging public health emergencies like COVID-19 is limited by the number of available BSL-3 trained and experienced research professionals. Our Pandemic Preparedness and Response Integrated Research Core (PaPR Core) responds to the substantially increased requests for our BSL-3 research services by organizing an integrated full-service BSL-3 research support function to support investigator needs. These cores will work in unison to achieve the CPM mission: to prepare for and respond to public health emergencies like the COVID-19 pandemic.

摘要（总体）： 路易斯维尔大学区域生物防护实验室 (RBL) 由大学中心运营 生物防御和新发传染病（CPM）的预测医学。 RBL 是区域资源 促进转化研究，开发诊断、预测、治疗方法和疫苗，以缓解 生物防御和新出现的传染病威胁。我们中心运营唯一的 BSL-3 和 ABSL-3 设施 目前在肯塔基州运营。 CPM 的任务是为公众做好准备并做出回应 突发卫生事件，例如 COVID-19 大流行。 路易斯维尔大学 (UofL) CPM RBL 的广泛、长期目标是： 1. 为地区和国家生物医学研究界提供最先进的研究服务 学习过去的流行病和生物战经验并有效预测和减轻未来的影响 新出现的传染病威胁。 2. 管理、维护和运营伦敦大学 RBL，以满足国家和地区的生物防护需求 适合研究风险组 3 病原体和其他生物威胁的设施。 3. 遵循持续改进 BSL-3 和 ABSL-3 工作实践的理念，并确保 所有需要进入 BSL-3 和 ABSL-3 收容实验室的人员都经过适当的培训并 准备满足国家和地区对生物防护研究专业人员的需求。 为了实现这些目标，我们建议建立三个协作核心。设施管理 维护和运营核心（FMMO 核心）负责确保设施始终可用 以满足 RBL 的研究和应急准备任务。 BSL-3 实践和劳动力 开发核心（BSL-3PWD 核心）正式制定我们的导师-受训者培训计划，以确保我们的实验室 配备了精通生物防护研究专业人员的 BSL-3 研究专业人员。这个核心 回应了这样一个现实，即对迅速出现的突发公共卫生事件（如 COVID-19）的反应受到以下因素的限制： 受过 BSL-3 培训且经验丰富的研究专业人员的数量。我们的流行病准备 响应综合研究核心（PaPR Core）响应大幅增加的要求 BSL-3 研究服务通过组织综合的全方位服务 BSL-3 研究支持功能来支持 调查员的需要。这些核心将齐心协力，实现 CPM 的使命：做好准备并应对 COVID-19 大流行等突发公共卫生事件。