Children's Research Institute Hematology Research Training Grant

儿童研究所血液学研究培训补助金

• 批准号: 9025570
• 负责人: NAOMI L LUBAN
• 金额: --
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9025570
• 关键词: Child; Grant; Hematology; Research Institute; Research Training

PROJECT SUMMARY The conduct of high quality and transformative research in pediatric transfusion medicine and hematology is complicated by several barriers including, 1) lack of a robust infrastructure for research training and implementation; 2) shortage of mid-career and senior investigators to serve as research mentors; 3) need for multidisciplinary translational approaches to answer critical clinical questions; 4) lack of diversity among clinical and translational investigators with respect to minority status and gender despite a disproportionate number of under-represented infants and children minority with diseases and disorders which could benefit from such investigations. We use this application to propose a highly collaborative and multidisciplinary, inter-institutional program of mentored training for future scientists in pediatric transfusion medicine and hematology that will address these barriers. It will focus on advancing clinical and translational scholarship on the diagnosis and clinical management of hematological, cardiovascular and pulmonary disorders, transfusion and transplantation. The program, the Pediatric Hematology and Transfusion Medicine Multidisciplinary Research Training Award (PHTMMRT) will have the long-term objective of preparing trainees from diverse backgrounds for academic leadership and independently funded research careers. Each trainee in the program will complete a Master's Degree in Clinical and Translational Science (MsCTR) at the George Washington University School of Medicine and Health Sciences (GWU) and will devise, implement and complete a research project under the joint oversight of multidisciplinary mentorship team. At the completion of the three year program, each trainee will have presented his/her data at least at one national research meeting, drafted and submitted one or more manuscripts suitable for external peer-reviewed publications, and submitted an external grant application to the NIH or equivalent funding source. The program will be overseen by two highly qualified and NIH-funded Principal Investigators/Program Directors (PIs/PDs) with distinct and complementary clinical backgrounds and research expertise. They will be supported by 9 faculty of Children's National and its affiliated GWU School of Medicine and Health Sciences (GWU) with 9 external mentors who are research scientists with expertise in coagulation, transfusion medicine, transplantation, sickle cell disease and vascular biology. A Diversity Enhancement Officer, a full professor and funded investigator, will assist in the recruitment of minority, disabled or disadvantaged applicants, and women. Finally, an External Advisory Committee, composed of 6 NIH-funded national leaders in transfusion medicine and hematology with established career mentorship programs, will offer annual feedback and guidance with respect to development of the PHTMMRT program and to the trainees' progress. The PHTMMRT program will directly address each of the barriers noted above by leveraging several of Children's National's (CNMC) multiple and pre-existing strengths with collaborating neighboring research institutions including the NIH, American Red Cross, FDA and Howard University School of Medicine which provide outstanding training opportunities. These strengths include 1.a) the availability of translational and clinical scientists across the full spectrum from mechanistic investigations to health services research; 1.b) a pool of experienced NIH funded faculty who with our external mentors provide access to unparalleled core facilities and research training; 2) our large, local community of K Scholars and other trainees which, through a Council of Trainees, will provide collegial, formal and informal, interdisciplinary learning opportunities in team science; 3) our robust CTSA-funded infrastructure for supporting trainee research, including a MS in Clinical and Translational Research; 4) our longstanding commitment to recruit and train investigators from diverse clinical disciplines who are under-represented minorities or women. Our multidisciplinary, inter-institutional mentors will train four future academic leaders in Pediatric Hematology and Transfusion Medicine, who will lead both clinical and translational research teams, compete successfully for grant support and provide novel insights into the causes, pathophysiology and treatment of pediatric diseases that affect the Nation's children.

项目概要 在儿科输血医学和血液学领域开展高质量和变革性的研究是 由于几个障碍而变得复杂，包括：1）缺乏强大的研究培训基础设施和 执行; 2）缺乏担任研究导师的中高级研究人员； 3）需要 多学科转化方法来回答关键的临床问题； 4）临床缺乏多样性 和关于少数群体地位和性别的翻译调查员，尽管数量不成比例 患有疾病和失调的婴儿和儿童人数不足，但可以从此类治疗中受益 调查。 我们使用此应用程序提出一个高度协作、多学科、跨机构的项目 为儿科输血医学和血液学领域的未来科学家提供指导培训，以解决这些问题 障碍。它将专注于推进诊断和临床方面的临床和转化学术。 血液学、心血管和肺部疾病、输血和移植的管理。这 计划，儿科血液学和输血医学多学科研究培训 奖项 (PHTMMRT) 的长期目标是让来自不同背景的学员做好准备 学术领导力和独立资助的研究生涯。该计划中的每位学员将完成 乔治华盛顿大学临床与转化科学硕士学位 (MsCTR) 医学与健康科学（GWU）并将在该项目下设计、实施和完成一个研究项目 多学科导师团队的联合监督。三年计划结束后，每位学员 至少在一次全国研究会议上展示过他/她的数据，起草并提交了一份或多份 适合外部同行评审出版物的手稿，并向 NIH 或同等资金来源。该计划将由两位高素质且由 NIH 资助的专家监督 首席研究员/项目总监 (PI/PD) 具有独特且互补的临床背景， 研究专业知识。他们将得到国家儿童医院及其附属乔治华盛顿大学学校的 9 名教员的支持 医学与健康科学 (GWU) 拥有 9 名外部导师，他们都是在以下领域具有专业知识的研究科学家 凝血、输血医学、移植、镰状细胞病和血管生物学。多样性 增强官员是一名正教授和受资助的研究员，将协助招募少数族裔、 残疾或弱势申请人以及女性。最后，一个外部咨询委员会，由 6 名成员组成 美国国立卫生研究院 (NIH) 资助输血医学和血液学领域的国家领导人并提供职业指导 计划，将提供有关 PHTMMRT 计划开发的年度反馈和指导， 为了学员的进步。 PHTMMRT 计划将通过利用以下几个因素来直接解决上述每个障碍： 国家儿童基金会 (CNMC) 与邻近研究机构合作的多重优势和现有优势 NIH、美国红十字会、FDA 和霍华德大学医学院等机构 提供出色的培训机会。这些优势包括 1.a) 翻译和翻译的可用性 从机械研究到卫生服务研究的各个领域的临床科学家； 1.b)a 经验丰富的 NIH 资助教师队伍，与我们的外部导师一起提供无与伦比的核心知识 设施和研究培训； 2) 我们由 K 学者和其他学员组成的大型当地社区，通过 学员理事会将在团队中提供学院式、正式和非正式的跨学科学习机会 科学; 3) 我们强大的 CTSA 资助的基础设施，用于支持实习生研究，包括临床硕士学位 和转化研究； 4) 我们长期致力于招募和培训来自不同领域的调查人员 临床学科中代表性不足的少数族裔或女性。 我们的多学科、跨机构导师将培训四位未来的儿科血液学学术带头人 和输血医学将领导临床和转化研究团队，成功竞争 获得拨款支持，并对儿科疾病的病因、病理生理学和治疗提供新颖的见解 影响国家儿童的疾病。