New England Regional Coordinating Center for the NINDS Stroke Trials Network

NINDS 卒中试验网络新英格兰地区协调中心

基本信息

批准号：
9343382
负责人：
Lee H Schwamm
金额：
$ 13.73万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-10-01 至 2017-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9343382
关键词：
Academic Medical Centers Achievement Acute Address Adult Advocacy Agreement Ally American Heart Association Area Award Blood Vessels Boston Caring Child Clinical Clinical Investigator Clinical Research Clinical Sciences Clinical Trials Clinical Trials Network Collaborations Community Hospitals Data Discipline Discipline of Nursing Educational Activities Emergency Medicine Emergency treatment Enrollment Environment Faculty Failure Funding Future General Hospitals Goals Health Hospitals Inpatients Institution Institutional Review Boards Instruction International Investigation Israel Lead Leadership Letters Massachusetts Medical Medical center Mission Modeling Multicenter Trials National Institute of Neurological Disorders and Stroke Neurologist Neurology Neurosciences Research New England Operative Surgical Procedures Patient Care Patient-Focused Outcomes Patients Pediatric Hospitals Performance Phase Phase III Clinical Trials Physicians Population Heterogeneity Populations at Risk Positioning Attribute Pre-hospitalization care Principal Investigator Protocols documentation Public Health Recording of previous events Records Recovery Recurrence Rehabilitation therapy Research Research Activity Research Infrastructure Research Institute Research Personnel Research Training Resources Risk Role Rural Hospitals Science Seasons Services Site Stroke Stroke prevention Therapeutic Training Training and Infrastructure Translating Translational Research United States National Institutes of Health Universities University Hospitals Vision Woman acute stroke base experience improved improved outcome innovation member metropolitan multidisciplinary network models neuroimaging neurosurgery next generation novel novel therapeutics operation patient population pre-clinical programs research study skills stroke intervention stroke rehabilitation success treatment trial

项目摘要

We propose to create the New England Regional Coordinating Center (NERCC), an integrated team of hospitals and EMS agencies in Boston and Western Massachusetts that will serve as a top-enrolling site and vibrant contributor to the NINDS Stroke Trials Network. Our group includes many ofthe major adult academic stroke centers in the Greater Boston area, and our 30 hospital New England TeleStroke referral network will extend our potential recruitment even further. Ail core hospitals have a proven track record of successful management and performance ofclinical trials. In particular, ali hospitals have an established research infrastructure that performs ongoing clinical research in stroke neurology with strong collaborations across disciplines. Principal investigator Lee H. Schwamm, MD, and Co-Investigators bring a complementary set of skills in managing successful translational clinical research programs, membership on Steering Committees, and positions of national leadership in their fields. Our team includes seasoned clinical investigators in vascular neurology, emergency medicine, neuroendovascular, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and preclinical basic and translational stroke investigation in both adults and children. Strengths ofthe NERCC team include 1) close personal and professional ties between multiple investigators; 2) large patient population from diverse hospital settings in a major metropolitan area; 3) talented teams of site investigators with track records of scientific achievement, innovation, and subject recruitment in multicenter trials; 4) robust existing NINDS-funded research and clinical trial management infrastructure; 5) existing clinical research programs, e.g.. Neurology Clinical Research Institute, NIH Clinical and Translational Science Award programs at Boston University and across Harvard; Sites in the Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) and Neurology Emergency Treatment Trials and NeuroNEXT Clinical Coordinating Center. In addition, integration with Boston and Worcester prehospital services will be leveraged to support the goals ofthe NERCC. Overall, the NERCC Team has the resources, vision, and enthusiasm to develop new translational science and successfully execute the NINDS Stroke Trials Network Phase 1,2 and 3 studies. RELEVANCE (See Instructions): The NERCC will be comprised of Massachusetts General Hospital (MGH), Brigham & Women's Hospital (BWH), Beth Israel Deaconess Medical Center (BIDMC), Boston Medical Center (BMC), Tufts Medical Center (TMC), University of Massachusetts Memorial Medical Center (UMMMC), Spaulding Rehabilitation Hospital Network (SRH) and Boston Children's Hospital (BCH), all organizations with internationally recognized patient care and clinical research programs.

我们建议建立新英格兰地区协调中心（NERCC），这是一个由以下人员组成的综合团队波士顿和马萨诸塞州西部的医院和 EMS 机构将作为主要招生地点， NINDS 中风试验网络的活跃贡献者。我们的团队包括许多主要的成年人大波士顿地区的学术卒中中心，以及我们新英格兰的 30 家医院 TeleStroke 转诊网络将进一步扩大我们的潜在招聘范围。 Ail 核心医院拥有良好的记录临床试验的成功管理和表现。尤其是阿里医院已经建立了研究基础设施，通过强有力的合作进行中风神经病学的持续临床研究跨学科。首席研究员 Lee H. Schwamm 医学博士和联合研究员带来了补充管理成功的转化临床研究项目的一套技能，指导会员委员会以及各自领域的国家领导职位。我们的团队包括经验丰富的临床血管神经病学、急诊医学、神经血管内、神经外科、神经重症领域的研究人员护理、神经影像学、中风康复以及临床前基础和转化中风研究成人和儿童。 NERCC 团队的优势包括 1) 之间密切的个人和专业联系多名调查员； 2) 来自主要大都市地区不同医院环境的大量患者群体； 3) 才华横溢的现场调查人员团队，拥有科学成就、创新和主题记录多中心试验招募； 4) 强大的现有 NINDS 资助的研究和临床试验管理基础设施; 5）现有的临床研究项目，例如神经病学临床研究所、NIH临床波士顿大学和哈佛大学的转化科学奖项目；站点位于急性中风转化研究专业项目 (SPOTRIAS) 和神经病学急诊治疗试验和 NeuroNEXT 临床协调中心。此外，与波士顿的整合伍斯特院前服务将用于支持 NERCC 的目标。总体而言，NERCC 团队拥有资源、愿景和热情来开发新的转化科学并成功执行 NINDS 中风试验网络 1,2 和 3 期研究。相关性（参见说明）： NERCC 将由麻省总医院 (MGH)、布莱根妇女医院组成 (BWH)、贝斯以色列女执事医疗中心 (BIDMC)、波士顿医疗中心 (BMC)、塔夫茨医疗中心中心 (TMC)、马萨诸塞大学纪念医学中心 (UMMMC)、斯波尔丁康复中心医院网络 (SRH) 和波士顿儿童医院 (BCH)，所有组织都具有国际影响力公认的患者护理和临床研究项目。