POLYMER WITH STEPWISE-VARIABLE SURFACE COMPOSITIONS

表面成分逐步变化的聚合物

• 批准号: 2030351
• 负责人: ROBERT S WARD
• 金额: $ 7.85万
• 依托单位: POLYMER TECHNOLOGY GROUP, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 1998-03-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2030351
• 关键词: X ray spectrometry; atomic force microscopy; biomaterial development /preparation; chemical kinetics; chemical synthesis; electrospray ionization mass spectrometry; infrared spectrometry; photoelectron spectrometry; polymers; polyurethanes; surface property

Advancements in the science of biomaterials have been slow due in part to the lack of model materials with stepwise-variable surface composition. Furthermore, the ability to systematically control polymer surface chemistry would have great practical utility in the (empirical) development of new biomaterials for tissue engineering and for use in ex vivo and in vivo devices and prostheses. Our preliminary work suggests that while rates are significantly lower, equilibrium surface tension/composition of polymer blends is quantitatively similar to conventional liquid surfactants in liquid solvents. Surface energy minimization drives the process of surface equilibration which depends on the nature of the interface, e.g., air versus blood. The proposed study would measure the efficiency and effectiveness of novel surface-active solid polymers (with surface-modifying oligomeric end groups), in a model base polymer. The hypothesis to be tested is that amorphous or semi-crystalline polymers are 'liquids in slow motion' with regard to surface chemistry versus bulk composition. A positive outcome would explain time-dependent changes in polymer surface composition following processing or a change in environment. Verification of the similarities between solid/solid polymer blends and liquid/liquid blends would provide a foundation for problem solving in a wide range of polymer applications involving control of surface chemistry. The results of Phase I will be used during Phase H to develop commercial process for polymer surface modification that have a variety of end uses, including tubing, blood filters, blood oxygenator, blood fractionation/blood storage, and other non-medical applications. PROPOSED COMMERCIAL APPLICATIONS These polymers are particularly suitable for use in the manufacture of medical devices intended to be used in contact with blood and tissue. Examples of medical devices include catheters, vascular grafts, prosthetic heart valves, various blood pumps and artificial organs.

由于以下原因，生物材料科学的进展缓慢 部分原因是缺乏具有逐步变化表面的模型材料 作品。此外，系统控制的能力 聚合物表面化学将在以下方面具有巨大的实际用途 （经验）组织工程新型生物材料的开发 并用于离体和体内装置和假肢。 我们的 初步工作表明，虽然利率明显较低， 聚合物共混物的平衡表面张力/组成为 与液体中的常规液体表面活性剂在数量上相似 溶剂。表面能最小化驱动表面过程 平衡取决于界面的性质，例如， 空气与血液。拟议的研究将衡量效率 新型表面活性固体聚合物（具有 表面改性低聚端基），在模型基础聚合物中。 要检验的假设是非晶态或半晶态 就表面而言，聚合物是“慢运动的液体” 化学与本体成分。积极的结果可以解释 聚合物表面成分随时间变化 处理或环境改变。 验证 固体/固体聚合物共混物和液体/液体之间的相似之处 混合将为解决广泛的问题提供基础 涉及表面控制的聚合物应用范围 化学。第一阶段的结果将在 H 阶段使用 开发聚合物表面改性的商业工艺 有多种最终用途，包括管道、血液过滤器、血液 氧合器、血液分离/血液储存和其他非医疗 应用程序。 拟议的商业应用 这些聚合物特别适合 适用于制造医疗器械 用于与血液和组织接触。 医疗的例子 装置包括导管、血管移植物、人工心脏瓣膜、 各种血泵和人造器官。