POLYMERS WITH STEP-WISE VARIABLE SURFACE COMPOSITION

具有阶梯式可变表面组成的聚合物

• 批准号: 6299118
• 负责人: ROBERT S WARD
• 金额: $ 41.33万
• 依托单位: POLYMER TECHNOLOGY GROUP, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6299118
• 关键词: X ray spectrometry; atomic force microscopy; biomaterial development /preparation; chemical kinetics; chemical synthesis; electrospray ionization mass spectrometry; fluorocarbon polymers; infrared spectrometry; photoelectron spectrometry; polyethylenes; polymers; polyurethanes; silicon; surface property

DESCRIPTION (Verbatim from the Applicant's Abstract): The application of biomaterials science to devices now in development would benefit from the availability of well-characterized polymers with step wise variable surface composition. Control of surface chemistry bulk composition has utility in tissue engineering, in fabrication of conventional medial devices and in new nanotechnology application of polymers. In Phase we confirmed that, while rates are slower, equilibrium surface tension/composition of polymer blends is quantitatively similar to conventional surfactants in liquid Solvents. Energy minimization drives surface equilibration, which depends on the nature of the interface, e.g., air vs. blood. Phase II involves preparation of three series of polymer blends with varying surface composition, each with a different surface modifying end group: silicone, fluorocarbon, polyethyleneoxide. Each series will be characterized by several surface-sensitive methods including Sum Frequency Generation Spectroscopy, XPS, AFM and surface tension/wettability. Each characterized series will be subjected to a battery of short-term in vitro biological tests including (competitive) protein adsorption and complement activation. The hypothesis to be testes is that biological response will vary monotonically with surface chemistry when the surface chemistry is determined by truly surface-sensitive methods and knowledge of the kinetics of polymer surface rearrangement following upon immersion of air-equilibrated surfaces into aqueous fluids. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（逐字病申请人的摘要）： 现在开发的设备生物材料科学将受益于 符合特征良好的聚合物的可用性具有逐步可变表面 作品。控制表面化学的大量组成具有实用性 组织工程，制造常规内侧设备和新的 聚合物的纳米技术应用。在阶段，我们确认，虽然比率 较慢，平衡表面张力/聚合物混合物的组成是 定量类似于液体溶剂中常规表面活性剂。活力 最小化驱动表面平衡，这取决于 界面，例如空气与血液。第二阶段涉及三个系列的准备 聚合物混合的表面组成不同，每种都有不同 表面修饰末端组：硅酮，碳碳，聚乙烯氧化物。 每个系列将以几种表面敏感方法的特征 包括总和频谱光谱，XPS，AFM和表面 张力/润湿性。每个特征系列都将进行电池电池 短期体外生物学测试包括（竞争性）蛋白 吸附和补体激活。睾丸的假设是 当生物学反应随表面化学而单调的变化 表面化学由真正的表面敏感方法确定 了解聚合物表面重排的动力学之后 将空气平衡的表面浸入水性流体中。 拟议的商业应用程序：不可用