NEW CHIRAL STATIONARY PHASES FOR CHROMATOGRAPHY

用于色谱的新型手性固定相

• 批准号: 2430501
• 负责人: JOSEPH J PESEK
• 金额: $ 4.83万
• 依托单位: SAN JOSE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-06-01 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2430501
• 关键词: benzoates; biomedical equipment development; chemical synthesis; chromatography; silanes; stereoisomer

The focus of the proposed project is on the development of new stationary phases for chiral separations in several different chromatographic methods: high performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC) and capillary electrochromatography (CEC). The separation of enantiomers is an increasingly important analytical problem in drug development, agrochemicals and biotechnology. New approaches for chiral separations are needed in both the monitoring of enantiomeric purity as well as for the preparation of optically pure materials. HPLC can be used for both analytical and preparative purposes. While chiral stationary phases are currently available, they are not applicable to all enantiomeric separations so the development of new types of phases is needed, especially for preparative purposes. Some new types of materials based on proven synthetic approaches using novel compounds are discussed in this proposal. The new phases which will be initially tested for HPLC followed by further development in SFC and CEC via a new capillary format. This technique involves etching the inner walls of the capillaries to increase the surface area and than bonding the desired chiral entity to the new surface to improve solute/bonded phase interactions. The combination of new chiral materials as well as new approaches for enantiomeric separations should result in expanded capabilities for both analytical and preparative purposes.

拟议项目的重点是开发新的固定 在几种不同色谱中手性分离的相 方法：高性能液相色谱（HPLC），超临界 流体色谱法（SFC）和毛细血管电典（CEC）。这 对映异构体的分离是一个越来越重要的分析问题 在药物开发中，农业化学和生物技术。新方法 在对映体的监测中都需要手性分离 纯度以及光学纯材料的制备。 HPLC 可用于分析和制备目的。手性 固定阶段目前可用，它们不适用于所有人 对映体分离，因此新类型的阶段的发展是 需要，特别是出于准备目的。一些新型材料 讨论了使用新颖化合物的经过验证的合成方法 在此提案中。最初将对HPLC测试的新阶段 然后通过新的毛细管格式在SFC和CEC进行进一步开发。 该技术涉及将毛细血管的内壁蚀刻到 增加表面积并将所需的手性实体结合到 改善溶质/键相互作用的新表面。这 新的手性材料以及新方法的结合 对映体分离应导致两者的扩展能力 分析和制备目的。