Rechargeable Antimicrobial Dental Unit Waterline Tubing

可充电抗菌牙科综合治疗机水管

• 批准号: 7495800
• 负责人: YUYU SUN
• 金额: $ 7.66万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7495800
• 关键词: bacteria infection mechanism; biofilm; biomaterial development /preparation; biomedical device power system; biomedical equipment safety; chemical synthesis; dental materials; disinfectants; plastics; water quality; water supply

DESCRIPTION: Given the formation and subsequent sloughing off of microbial biofilms from the inner surfaces of plastic tubing, Dental unit water is heavily contaminated with microorganisms. These microorganisms pose a potentially significant threat to Dental-care workers and patients, particularly those who are medically compromised or immunocompromised. The long-range goal of this project is to use N-halamine-based rechargeable antimicrobial tubing to control the formation of Dental unit waterline biofilms. The Specific Aims of the proposed research are to: 1) covalently bind N-halamine structures into plastic tubing, using simple and practical grafting methods; 2) characterize the antimicrobial activity, rechargeability, and mechanical properties of the new tubes; 3) evaluate the biofilm-controlling function and the safety of the new tubes in model Dental water delivery systems; and 4) provide preliminary data on the cost of the new approach. To achieve these goals, in the proposed research, polymerizable N-halamine precursors will be covalently bound onto plastic tubes using a "reactive-extrusion" approach. After extrusion, the new tubes will be treated with chlorine bleach to transform the covalently bound N-halamine precursors into N-halamines. The antimicrobial activities, stabilities, and rechargeabilities of the new N-halamine-containing tubes will be fully characterized. Selected tube samples will be challenged in model Dental water delivery systems with mixed species of water-borne bacteria to test the biofilm-controlling efficiency of the tubes. The cost-effectiveness of the new approach will be further evaluated. If successful, the rechargeable antimicrobial tubing technology will provide an innovative solution to the biofilm problem in Dental unit water delivery systems. Furthermore, the antimicrobial plastic tube materials to be developed in this study may also find applications in other clinically important surfaces. All these will make significant contributions to a better and safer healthcare environment.

描述：鉴于塑料管内表面微生物生物膜的形成和随后脱落，牙科设备的水受到微生物的严重污染。这些微生物对牙科护理人员和患者构成潜在的重大威胁，特别是那些身体状况不佳或免疫功能低下的人。该项目的长期目标是使用基于 N-halamine 的可充电抗菌管来控制牙科设备水线生物膜的形成。本研究的具体目标是：1）使用简单实用的接枝方法将 N-卤胺结构共价结合到塑料管中； 2) 表征新管的抗菌活性、可充电性和机械性能； 3）评估牙科模型输水系统中新型管的生物膜控制功能和安全性； 4) 提供有关新方法成本的初步数据。 为了实现这些目标，在拟议的研究中，可聚合的 N-卤胺前体将使用“反应挤出”方法共价结合到塑料管上。挤出后，新管将用氯漂白剂处理，将共价结合的 N-卤胺前体转化为 N-卤胺。 新型含 N-卤胺的抗菌活性、稳定性和可充电性 管将被充分表征。选定的管样品将在模型牙科输水系统中接受混合水生细菌种类的挑战，以测试管的生物膜控制效率。新方法的成本效益将得到进一步评估。 如果成功，可充电抗菌管技术将为以下领域提供创新的解决方案： 牙科治疗台供水系统中的生物膜问题。此外，本研究中开发的抗菌塑料管材料也可能在其他临床重要表面上得到应用。所有这些都将为更好、更安全的医疗环境做出重大贡献。