Development of Etched Modified Capillaries

蚀刻改性毛细管的开发

• 批准号: 6550299
• 负责人: JOSEPH J PESEK
• 金额: $ 7.5万
• 依托单位: MICROSOLV TECHNOLOGY CORPORATION
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-23 至 2003-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6550299
• 关键词: ammonium compounds; biomedical equipment development; capillary electrophoresis; chromatography; electrochemistry; hydroxyl group; polymers; proteomics; scanning electron microscopy; silicon compounds; spectrometry; surface coating; surface property

DESCRIPTION (provided by applicant): This STTR proposal describes a collaborative project between San Jose State University and Microsolv Technology Corporation for the development and marketing of etched modified capillaries for use in capillary electrophoresis and related techniques. The focus of the development involves a format for etching fused silica capillaries with ammonium hydrogen difluoride followed by chemical modification through attachment of an organic moiety to the capillary wall or by physically coating a polymer or surfactant. The bonding process utilizes the silanization/hydrosilation method in order to attach the organic moiety with a stable silicon-carbon linkage. The likely applications of these materials involve pharmaceuticals, peptides and proteins. Through cooperative arrangements between Microsolv and a number of industrial labs, the etched modified capillaries will be tested for their usefulness in practical applications. The major development work will continue at San Jose State in order to improve on the formats currently available as well as to fabricate new materials for a broader range of applications or in response to feedback from the industrial lab tests. Microsolv Corporation will undertake a marketing plan to distribute the products for use by companies working in the targeted application areas.

描述（由申请人提供）：该STTR提案描述了圣何塞州立大学与Microsolv Technology Corporation之间的合作项目，用于开发和营销蚀刻的修改后的毛细管，用于用于毛细管电泳和相关技术。该开发的重点涉及一种用于用氢铵二氟化铵蚀刻熔融二氧化硅毛细血管的格式，然后通过将有机部分连接到毛细管壁上或通过物理涂层聚合物或表面活性剂来进行化学修饰。键合过程利用硅烷化/氢化方法将有机部分连接起来，以稳定的硅碳连锁。这些材料的可能应用涉及药物，肽和蛋白质。通过Microsolv和许多工业实验室之间的合作安排，将对蚀刻的修改后的毛细血管进行测试，以实现其在实际应用中的用处。为了改善目前可用的格式，以及为更广泛的应用程序或响应工业实验室测试的反馈，将继续在圣何塞州继续进行主要的开发工作。 Microsolv Corporation将制定一项营销计划，以分销针对目标应用领域的公司使用的产品。