PREVENTION OF CHRONIC ASTHMA IN YOUNG CHILDREN

预防幼儿慢性哮喘

• 批准号: 2005675
• 负责人: Mary D. Klinnert
• 金额: $ 42.58万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2005675
• 关键词: airborne allergen; antiinflammatory agents; asthma; case history; child behavior; clinical research; disease /disorder prevention /control; health care cost /financing; health care service utilization; home health care; human subject; immunoglobulin E; infant human (0-1 year); low socioeconomic status; maternal behavior; middle childhood (6-11); nursing intervention; preschool child (1-5); quality of life; respiratory infections

DESCRIPTION: The goal of this five year research demonstration and education project is to determine if an intensive intervention using nurse home visitors can reduce asthma prevalence among children from low income households who begin wheezing in infancy. One hundred eighty infants and their parents who are Medicaid-eligible will be recruited from public health settings. About half of the children will be from minority families. Families will be randomly assigned to a nurse home visitor intervention group or a control group. In the intervention group, nurse home visitors will work with parents for one year to target allergens in the home, reduce environmental tobacco smoke, and improve the quality of maternal caregiving, particularly as it relates to asthma prevention and management. A control group will receive information related to preventing asthma. Repeated assessments of the targeted variables will be made in both groups. In addition, family history of asthma and children's IgE levels at enrollment will be assessed, since these variables are expected to interact with the targeted variables to affect outcome. Maternal psychological resources also will be assessed, as this factor has been associated with responsivity to home visitor interventions. Respiratory infections and use of anti-inflammatory medications will be monitored as possible mediating variables. All children will be followed to 4 years of age. Outcomes to be measured include asthma status, functional severity of asthma by maternal report and by cumulative symptom reports, pulmonary functions and IgE levels, quality of life and child behavioral adjustment, and health care use and costs. The principal investigator is Mary Klinnert, Ph.D., who is Chief of Pediatric Psychology at the National Jewish Center for Immunology and Respiratory Medicine and Associate Professor of Psychiatry at the University of Colorado Health Sciences Center. Co-investigators are Lanny Rosenwasser, M.D., Larry Borish, M.D., and Andy Liu, M.D.

描述：本五年研究示范的目标和 教育项目是确定是否使用护士进行强化干预 家访可以降低低收入儿童的哮喘患病率 在婴儿期就开始喘息的家庭。 一百八十名婴儿和 他们符合医疗补助资格的父母将从公共卫生部门招募 设置。 大约一半的孩子来自少数民族家庭。 家庭将被随机分配接受护士家访干预 组或对照组。 在干预组中，护士之家探访者 将与家长合作一年，针对家中的过敏原，减少 环境烟草烟雾，提高孕产妇护理质量， 特别是因为它与哮喘预防和管理有关。 一个控制 小组将收到有关预防哮喘的信息。 重复 将对两组的目标变量进行评估。 在 此外，哮喘家族史和儿童入组时的 IgE 水平 将进行评估，因为这些变量预计会与 影响结果的目标变量。 母亲的心理资源也 将进行评估，因为该因素与对 家庭访客干预。 呼吸道感染及其使用 将尽可能监测抗炎药物 变量。 所有儿童都将被跟踪至 4 岁。 结果是 测量的内容包括母亲的哮喘状况、哮喘的功能严重程度 报告并通过累积症状报告、肺功能​​和 IgE 水平、生活质量和儿童行为调整以及医疗保健使用 和成本。 主要研究者是 Mary Klinnert 博士，她是 国家犹太免疫学中心的儿科心理学和 大学呼吸内科和精神病学副教授 科罗拉多健康科学中心。 联合调查员是兰尼·罗森瓦瑟 (Lanny Rosenwasser) 医学博士、拉里·博里什（Larry Borish）医学博士和安迪·刘（Andy Liu）医学博士