EFFECT OF ETS EXPOSURE ON STEROID RESPONSIVENESS AMONG CHILDREN WITH ASTHMA

ETS 暴露对哮喘儿童类固醇反应的影响

• 批准号: 7604361
• 负责人: Mary D. Klinnert
• 金额: $ 0.98万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604361
• 关键词: Adrenal Cortex Hormones; Adult; Age; Area; Asthma; Blood; Blood Cells; Breathing; Caring; Cells; Child; Cigarette Smoker; Clinical; Computer Retrieval of Information on Scientific Projects Database; Effectiveness; Evaluation; Exposure to; Funding; Grant; Home environment; Infant; Inflammation; Institution; Laboratories; Low income; Lung; Morbidity - disease rate; Oral; Pattern; Pharmaceutical Preparations; Prednisone; Reporting; Research; Research Personnel; Resources; Schools; Smoker; Smoking; Source; Steroids; Symptoms; Testing; Tobacco smoke; United States National Institutes of Health; Week; base; cigarette smoking; non-smoker; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Children with asthma who are exposed to cigarette smoke have higher morbidity levels than those of children not exposed. Corticosteroids, either oral or inhaled, are among the most effective medications for asthma because they decrease inflammation that underlies asthma symptoms. A recent study showed that children who were given their inhaled steroids at school showed improvements compared to children with usual care; however, the improvement occurred only among the children not exposed to cigarette smoke at home. Among adults with asthma, cigarette smokers do not respond to oral steroids as well as non-smokers, and and studies of cells show the ways in which the cells of smokers are not responsive to steroids. In this study we will test the effectiveness of steroids among low-income children who participated in a study since they were infants and who were found at age 7 to have asthma. We hypothesize that children with asthma who area exposed to cigarette smoke will respond more poorly to a course of oral steroids than will the non-exposed children, and that their clinical responsiveness will be reflected in tests done on their blood cells. The children will come in to the laboratory where symptom reports and lung testing will be used to determine whether their asthma is being poorly controlled, their blood will be drawn, and their exposure to cigarette smoke will be evaluated. Those who are in poor control will receive prednisone (an oral steroid) for one week. They will return for an evaluation based on lung testing and symptom report to determine their clinical response to the prednisone. Their blood will be tested to see if the steroid response patterns identified among smoking with adults with asthma is similar among children with asthma who are exposed to secondhand tobacco smoke.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 接触香烟烟雾的哮喘儿童的发病率高于未接触香烟烟雾的儿童。皮质类固醇，无论是口服还是吸入，都是治疗哮喘最有效的药物之一，因为它们可以减少哮喘症状的炎症。 最近的一项研究表明，与接受常规护理的儿童相比，在学校接受吸入类固醇治疗的儿童的情况有所改善。然而，这种改善只发生在那些在家中没有接触过香烟烟雾的儿童中。 在患有哮喘的成年人中，吸烟者对口服类固醇的反应不如不吸烟者，并且细胞研究表明吸烟者的细胞对类固醇没有反应。 在这项研究中，我们将测试类固醇对低收入儿童的有效性，这些儿童从婴儿时期就参加了一项研究，并在 7 岁时被发现患有哮喘。 我们假设暴露于香烟烟雾的哮喘儿童对口服类固醇疗程的反应比未暴露的儿童更差，并且他们的临床反应将反映在对他们的血细胞进行的测试中。 孩子们将进入实验室，根据症状报告和肺部测试来确定他们的哮喘是否控制不佳，对他们进行抽血，并评估他们接触香烟烟雾的情况。控制不佳的患者将接受泼尼松（一种口服类固醇）一周。 他们将返回根据肺部测试和症状报告进行评估，以确定他们对泼尼松的临床反应。 他们的血液将被测试，看看在患有哮喘的成人吸烟者中发现的类固醇反应模式是否与接触二手烟草烟雾的哮喘儿童相似。