Cognitive Neuroscience of Development and Aging (CONDA) Center

发育与衰老认知神经科学 (CONDA) 中心

• 批准号: 10854463
• 负责人: Anna Dunaevsky
• 金额: $ 120.49万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10854463
• 关键词: Acceleration; Address; Administrative Supplement; Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Amyloid; Area; Award; Behavioral; Biological; Biological Assay; Brain; Brain imaging; Centers of Research Excellence; Child; Childhood; Chronology; Clinical; Cognitive; Collaborations; Communities; Complement; Core Facility; DNA Methylation; Data Set; Dedications; Development; Disease; Disease Outcome; Elderly; Electroencephalography; Emotional; Enrollment; Ensure; Equipment; Evaluation; Faculty; Family; Fellowship; Financial Support; Funding; Future; Genetic; Genotype; Geriatric Assessment; Goals; Government; Grant; Health; Hospitals; Human; Impaired cognition; Individual; Institution; Internships; Interpersonal Relations; Laboratories; Lead; Longevity; Machine Learning; Magnetic Resonance Imaging; Measures; Medical center; Mentors; Methods; Mission; Modality; Monitor; National Institute of General Medical Sciences; National Institute on Alcohol Abuse and Alcoholism; Nebraska; Nerve Degeneration; Neuropsychology; Neurosciences; Neurosciences Research; Onset of illness; Outcome; Parents; Participant; Physiological; Pilot Projects; Plasma; Postdoctoral Fellow; Registries; Research; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Risk Factors; Sampling; Science; Scientist; Series; Severity of illness; Social Functioning; Social Interaction; Social Network; Speed; Structure; Support System; Symptoms; System; Targeted Research; Testing; Text; Training; United States National Institutes of Health; Universities; affective neuroscience; behavioral outcome; boys; brain research; career development; cognitive ability; cognitive change; cognitive development; cognitive neuroscience; cognitive system; cohort; computational neuroscience; design; dyadic interaction; emotional factor; frontier; genetic risk factor; genome wide association study; grandparent; innovation; interest; member; multidisciplinary; multimodality; nervous system disorder; neurodevelopmental effect; neuroimaging; neuropathology; neuropsychiatric symptom; neuropsychiatry; neuroregulation; novel; novel strategies; programs; recruit; social; social factors; success; tau Proteins; tool; training opportunity

Project Summary Goals of Parent Award (Original Abstract Text) This application for a Center of Biomedical Research Excellence (COBRE) would initiate a formal Center to lead, support, and expand neuroimaging and clinical cognitive neuroscience research in Nebraska, with an emphasis on lifespan development. It is an opportune moment for human neuroscience research in the Omaha community, regionally, and across the world, with many new research tools and government initiatives intended to illuminate the next frontier of biomedicine. The proposed Cognitive Neuroscience of Development and Aging (CONDA) Center will provide critical resources and support to faculty from four institutions: the University of Nebraska Medical Center (UNMC), the Boys Town National Research Hospital, the University of Nebraska – Omaha, and Creighton University. The Administrative Core of the CONDA Center will be housed at UNMC, which is less than two miles from each of the other institutions, and will be comprised of Training, Evaluation, Engagement, Administration, and Mentoring areas (i.e., the TEEAM Core). The new CONDA Center will also include a state- of-the-art Neuroimaging Acquisition and Analysis Core, as well as extensive support for four primary COBRE research projects led by a promising group of NIH-defined early-stage investigators. Upon initiation of the Center, the TEEAM Core would immediately implement a series of new programs that are designed to develop human cognitive neuroscience on the CONDA Campus and across the region. The TEEAM Core would also rapidly implement a comprehensive research support structure that includes the Neuroimaging Core facility, training opportunities, pilot projects and mini-grants programs, a new seminar series, postdoctoral fellowships, intern- ships for growing temporary and long-term laboratory staffing, and a participant registry to enhance recruitment. In parallel, the TEEAM Core would promote the successful launch of the primary COBRE research projects and, through a mentoring network approach, implement a career development and evaluation support system to monitor progress and ensure Junior PIs and their mentoring teams reach critical milestones. As per the new research core, the Neuroimaging Acquisition and Analysis Core facility would be the only core dedicated to human brain research in the state of Nebraska, and would provide regional scientists with state-of-the-art tools for neuroimaging and neuromodulation, including research-dedicated MRI and MEG systems. The new Center would also receive exceptional institutional support, including financial support for CONDA programs, major equipment expenses, and Core staffing. The overall CONDA team includes an established group of PIs in neuro- imaging, brain dynamics, aging, and brain and cognitive development, as well as a strong cohort of emerging junior investigators using innovative cognitive and affective neuroscience methods to address major questions in human neuroscience across the lifespan. Goals of the Team Science Supplement Proposal Our team science supplement proposal responds to NOT-GM-23-034 [Notice of Special Interest (NOSI): Availability of Administrative Supplements to IDeA Awards to Fund Team Science Development Projects], and it proposes research targeting a topic at the core of the CoNDA Center’s mission, studying the cognitive neuroscience of development and aging. Specifically, our proposal is titled “Elucidating the effects of polygenic AD risk on brain, cognitive, socioemotional, and behavioral outcomes in development and aging using a novel multimodal approach and a multigenerational sample”. The central premise of the proposed project is that lifespan development effects of genetic AD risk factors can be assessed with increased speed, rigor, and validity by enriching child samples with a matched, multigenerational sample of familial elders. Building on this premise, we propose to study the effects of Alzheimer’s disease polygenic risk (AD-PRS) on development and aging using an innovative multigenerational approach. Our new study will complement and extend the NIA-funded Polygenic Risk of Alzheimer’s disease in Nebraska Kids study (“PRANK”, R01 AG064247) that has enrolled more than 180 child participants. Here, we will enroll a new sample (N=72) consisting of the familial elders (age 65-85 years) of PRANK enrollees. We will measure brain, cognitive, and neuropsychiatric variables from the older adults along with AD risk factors (genetic) and AD biomarkers (neuropathological). This approach will allow us to pursue our four specific aims: Aim 1) Measure AD-related neuropathology and other brain variables in familial elders of PRANK participants led by Dr. Warren); Aim 2) Evaluate associations between AD-related cognitive/neuropsychiatric status and biological age in familial elders of PRANK participants led by CPL Dr. Beadle; Aim 3) Measure social factors including social network size, relationship quality, and dyadic interactions in familial elders of PRANK participants led by CPL Dr. Chen; and Aim 4) Measure the interactive effect of genetic AD risk factors and family connectedness on multi-modal brain age gaps using machine learning led by CPL Wang. Our innovative approach will provide key findings regarding the effects of AD-PRS in development and aging that would otherwise require decades of longitudinal monitoring of the same participants. Crucially, our team science approach is an essential part of this project. Our team includes diverse expertise in cognitive neuroscience, Alzheimer’s disease, development, aging, multiple neuroimaging methods, genetics, computational neuroscience, neuropathology, biospecimen assays, and more. Only by combining the effort of our outstanding team members could we pursue a project of this scope, and the team we build by completing this project will allow us to pursue additional research funding in the near future.

项目摘要 父母奖的目标（原始抽象文本） 该申请卓越生物医学研究中心（COBRE）将启动一个正式的中心，以领导， 支持并扩大内布拉斯加州的神经影像学和临床认知神经科学研究，重点 关于寿命的发展。这是奥马哈社区人类神经科学研究的机会时刻， 在区域以及世界各地，旨在阐明许多新的研究工具和政府倡议 提出的发展和衰老的认知神经科学（CONDA） 中心将为四个机构的教师提供关键的资源和支持：内布拉斯加州大学 医疗中心（UNMC），内布拉斯加州大学男孩镇国家研究医院 - 奥马哈和 克雷顿大学。康达中心的行政核心将安置在UNMC，少于 距离其他机构两英里，将完成培训，评估，参与， 管理和指导领域（即Teeam Core）。新的康达中心还将包括一个州 - 艺术神经影像学的获取和分析核心，以及对四个主要毛绒的广泛支持 由一群有前途的NIH定义的早期研究人员领导的研究项目。根据中心的主动 Teeam Core将立即实施一系列旨在发展人类的新程序 康达校园和整个地区的认知神经科学。 Teeam核心也将迅速 实施全面的研究支持结构，包括神经影像学核心设施，培训 机会，试点项目和迷你奖励计划，新的半段系列，博士后奖学金，实习生 - 发展临时和长期实验室人员配备的船，以及参与者注册中心，以增强招聘。 同时，Teeam Core将促进主要的毛绒研究项目的成功启动，以及 通过心理网络方法，将职业发展和评估支持系统实施 监视进度并确保初级PI及其心理团队达到关键的里程碑。根据新的 研究核心，神经影像学的获取和分析核心设施将是唯一致力于 内布拉斯加州州的人脑研究，并将为区域科学家提供最先进的工具 用于神经影像学和神经调节，包括研究的MRI和MEG系统。新中心 还将获得卓越的机构支持，包括对Conda计划的财务支持，主要 设备费用和核心人员配备。整个Conda团队包括一群既定的PIS in Neuro-- 成像，大脑动力学，衰老，大脑和认知发展，以及强大的新兴人群 初级研究人员使用创新的认知和情感神经科学方法来解决主要问题 在整个生命周期的人类神经科学中。 团队科学补充建议的目标 我们的团队科学补充提案对非GM-23-034的回应[特殊利益通知（NOSI）： 为思想奖励提供行政补品以资助团队科学发展项目]，并 它提出了针对康达中心任务核心的主题的研究，研究认知 发展和衰老的神经科学。具体而言，我们的建议标题为“阐明多基因的影响 使用新颖 多模式的方法和多代样本”。拟议项目的中心前提是 遗传AD风险因素的寿命发展影响可以通过提高，严格，严格， 通过用匹配的多代老年人样本丰富儿童样本来富含有效性。 在此前提的基础上，我们建议研究阿尔茨海默氏病多基因风险（ADPRS）的影响 使用创新的多代方法开发和衰老。我们的新研究将补充和 在内布拉斯加州儿童研究中扩展了NIA资助的阿尔茨海默氏病的多基因风险（“恶作剧”，R01 AG064247）已招募了180多名儿童参与者。在这里，我们将注册一个新样本（n = 72） 由家族长者（65-85岁）组成。我们将测量大脑，认知和 老年人的神经精神变量以及AD风险因素（遗传）和AD生物标志物 （神经病理学）。这种方法将使我们能够追求我们的四个特定目标：目标1）衡量与广告相关的 由沃伦博士领导的恶作剧参与者家庭长老中的神经病理学和其他大脑变量）；目标2） 评估与广告相关的认知/神经精神诊断状态与家庭老年生物年龄之间的关联 由CPL Beadle博士领导的恶作剧参与者；目标3）衡量社会因素，包括社交网络规模， 由CPL博士领导的恶作剧参与者的家庭长老中的关系质量和二元互动；和 目标4）衡量遗传AD风险因素和家庭联系对多模式大脑的互动效果 使用CPL Wang领导的机器学习年龄差距。我们的创新方法将提供有关有关的关键发现 AD-PR在开发和衰老中的影响，否则需要数十年的纵向监测 同一参与者。十足的是，我们的团队科学方法是该项目的重要组成部分。我们的团队 包括在认知神经科学，阿尔茨海默氏病，发育，衰老，多重方面的潜水专业知识 神经影像学方法，遗传学，计算神经科学，神经病理学，生物循环测定等。 只有结合我们杰出团队成员的努力，我们才能追求这个范围的项目，以及 我们通过完成该项目建立的团队将使我们能够在不久的将来获得更多的研究资金。

项目成果

Visualization of the Spatiotemporal Propagation of Interictal Spikes in Temporal Lobe Epilepsy: A MEG Pilot Study.

颞叶癫痫发作间期尖峰时空传播的可视化：MEG 试点研究。

• DOI: 10.1007/s10548-023-01017-z
• 发表时间: 2024
• 期刊: Brain topography
• 影响因子: 2.7
• 作者: Zhou,DanielJ;Gumenyuk,Valentina;Taraschenko,Olga;Grobelny,BartoszT;Stufflebeam,StevenM;Peled,Noam
• 通讯作者: Peled,Noam

International consensus recommendations for management of New Onset Refractory Status Epilepticus (NORSE) incl. Febrile Infection-Related Epilepsy Syndrome (FIRES): Statements and Supporting Evidence.

• DOI: 10.1111/epi.17397
• 发表时间: 2022-08-23
• 期刊: Epilepsia
• 影响因子: 5.6

Feeling physical pain while depressed: The effect of alexithymia.

抑郁时感到身体疼痛：述情障碍的影响。

• DOI: 10.12788/acp.0009
• 发表时间: 2020
• 期刊: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists
• 作者: Smirni,Daniela;Beadle,JanelleN;Paradiso,Sergio
• 通讯作者: Paradiso,Sergio

Movement disorders associated with antiseizure medications: A systematic review.

• DOI: 10.1016/j.yebeh.2022.108693
• 发表时间: 2022-06
• 期刊: EPILEPSY & BEHAVIOR
• 影响因子: 2.6
• 作者: Zhou, Daniel J.;Pavuluri, Spriha;Snehal, Isha;Schmidt, Cynthia M.;Situ-Kcomt, Miguel;Taraschenko, Olga
• 通讯作者: Taraschenko, Olga

Protocol for establishing a global ischemia model using a 4-vessel occlusion in rats.

• DOI: 10.1016/j.xpro.2023.102630
• 发表时间: 2023-12-15
• 期刊: STAR PROTOCOLS
• 作者: Kim, Hyunha;Urquhart, Rachael;Pontarelli, Fabrizio;Jover-Mengual, Teresa;Ofengeim, Dimitry;Hwang, Jee-yeon
• 通讯作者: Hwang, Jee-yeon