Translational Imaging and Behavioral Assessment (TIBA) Core

转化成像和行为评估 (TIBA) 核心

• 批准号: 10654518
• 负责人: Anna Dunaevsky
• 金额: $ 16.7万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10654518
• 关键词: Aging; Animal Model; Behavior; Behavior assessment; Behavioral Research; Cognition Disorders; Communities; Data Set; Development; Equipment; Funding; Individual; Infrastructure; Interdisciplinary Study; Magnetic Resonance Imaging; Mentors; Methodology; Modality; Multimodal Imaging; Neurocognitive; Neurodegenerative Disorders; Neurodevelopmental Disorder; Optics; Positron-Emission Tomography; Research; Resources; Rodent; Structure; Study models; animal imaging; cognitive neuroscience; cognitive testing; experimental study; image translation; imaging facilities; imaging modality; imaging study; improved; in vivo imaging; innovation; instrumentation; multiphoton microscopy; neural; neurocognitive disorder; pre-clinical; preclinical imaging; translational model

The Translational Imaging and Behavioral Assessment (TIBA) Core will provide state of the art infrastructure for preclinical translational imaging studies using optical and other modalities to study neural structure and activity as well as cognitive assessment in translational models for neurodevelopmental and neurodegenerative disorders. This core will be composed of a preclinical imaging center which bundles several small animal imaging modalities. These include Multiphoton Microscopy, 7T MRI and a new PET scanner, allowing multimodal imaging in animal models for the study of normative cognition and neurocognitive disorders. This approach will result in innovative and rigorous preclinical translational datasets that are more powerful than the individual standalone imaging modalities. A second component of Core C, in keeping with the theme of the CoNDA center of cognitive assessments, is the new rodent behavior core. This core will provide the center with the expertise, equipment, and space that is required to conduct innovative behavioral research. A wide array of cognitive and behavioral assessments would dove-tail with the in vivo imaging experiments in the preclinical imaging center.

转化成像和行为评估（TIBA）核心将为临床前转化成像研究提供最先进的基础设施，使用光学和其他方式研究神经结构和活动，以及神经发育和神经退行性疾病转化模型中的认知评估。该核心将由一个临床前成像中心组成，该中心捆绑了几种小动物成像模式。其中包括多光子显微镜、7T MRI 和新型 PET 扫描仪，可在动物模型中进行多模态成像，以研究规范认知和神经认知障碍。这种方法将产生创新且严格的临床前转化数据集，这些数据集比单独的独立成像模式更强大。核心 C 的第二个组成部分是新的啮齿动物行为核心，与 CoNDA 认知评估中心的主题保持一致。该核心将为中心提供进行创新行为研究所需的专业知识、设备和空间。广泛的认知和行为评估将与临床前成像中心的体内成像实验相吻合。