Training in Musculoskeletal Science: Comprehensive Training in Pain Studies

肌肉骨骼科学培训：疼痛研究综合培训

• 批准号: 10853550
• 负责人: Hani A Awad
• 金额: $ 11.8万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10853550
• 关键词: Musculoskeletal; Pain; Science; Training

Abstract: This administrative supplement proposal aims to enhance the Rochester Training in Musculoskeletal Science (ROCMSK) Program by incorporating a comprehensive training curriculum on the mechanisms, measurement, and treatment of pain. The proposed curriculum will complement the existing interdisciplinary didactic, pedagogical, and research skills training in musculoskeletal science while filling a critical gap in pain assessment and management in orthopedic conditions. The training curriculum will be accessible to all trainees at every academic level within the CMSR program, with priority given to T32 trainees for experiential learning opportunities. The curriculum includes lecture-based instruction and immersive hands-on training, covering topics ranging from pain physiology and preclinical pain models to pain assessment methods and ethical considerations. The importance of rigor, reproducibility, and standardization of pain assessment methods will be emphasized. Trainees will have the opportunity to engage with renowned pain researchers through the CMSR's membership in the Chicago Center on Musculoskeletal Pain (C-COMP) and receive training on pain assessment techniques in rodents. Funding will be used to purchase pain behavior assessment instruments, enhancing the infrastructure for pain studies in the CMSR. Collaboration with C- COMP will enable resource sharing and training of future experts, ensuring sustainability of the pain curriculum within the ROCMSK T32 program. The proposal also aims to leverage national resources and create experiential learning opportunities for trainees through collaborations and participation in pain research initiatives and events. Trainees will benefit from virtual interactions with pain research experts through NIH's HEAL and PURPOSE Initiatives. The supplement will support trainees in attending in-person workshops, symposia, and conferences, including the Keystone Symposia on Mammalian Somatosensation and the International Association for the Study of Pain meeting. This approach will foster interdisciplinary collaboration and provide trainees with diverse perspectives on cutting-edge pain research. Furthermore, the proposal requests an additional training seat for an additional trainee to incorporate pain outcomes into his study of molecular mechanisms related to skeletal muscle wasting in a preclinical model of pancreatic cancer. This research has the potential to contribute to the development of new therapies for preventing or reversing skeletal muscle wasting in pancreatic cancer patients. Overall, this administrative supplement proposal seeks to enhance the ROCMSK Program by developing a comprehensive training curriculum on pain assessment and management in musculoskeletal conditions. Through didactic instruction, immersive hands-on training, experiential learning opportunities, and the addition of a trainee focusing on pain assessment in a pancreatic cancer model, this supplement aims to bridge the gap in interdisciplinary musculoskeletal science training and empower future researchers to address the complex issue of pain in orthopedic conditions.

摘要：该行政补充提案旨在增强肌肉骨骼的罗切斯特培训 科学（ROCMSK​​）计划通过纳入有关机制的全面培训课程， 测量和疼痛治疗。拟议的课程将补充现有的跨学科 肌肉骨骼科学的教学，教学和研究技能培训，同时填补了痛苦的关键空白 在骨科条件下的评估和管理。所有人都可以访问培训课程 CMSR计划中每个学术层面的学员 学习机会。该课程包括基于讲座的教学和沉浸式动手培训， 涵盖从疼痛生理和临床前疼痛模型到疼痛评估方法的主题 道德考虑。严格，可重复性和疼痛评估标准化的重要性 将强调方法。学员将有机会与著名的疼痛研究人员互动 通过CMSR在芝加哥肌肉骨骼疼痛（C-COMP）的会员资格并接受 啮齿动物中疼痛评估技术的培训。资金将用于购买疼痛行为 评估工具，增强了CMSR疼痛研究的基础设施。与C-合作 Comp将实现未来专家的资源共享和培训，以确保疼痛课程的可持续性 在Rocmsk T32程序中。该提案还旨在利用国家资源并创建 通过合作和参与疼痛研究的学员的体验式学习机会 倡议和事件。受训者将通过NIH与疼痛研究专家的虚拟互动受益 治愈和目的计划。该补充剂将支持受训者参加面对面的研讨会， 专题讨论会和会议，包括有关哺乳动物节感的基石座谈会和 国际疼痛研究协会。这种方法将促进跨学科合作 并为受训者提供有关尖端疼痛研究的不同观点。此外，提案 要求额外的训练座位让额外的学员将疼痛结果纳入他的研究 胰腺癌临床前模型中与骨骼肌浪费有关的分子机制。这 研究有可能为预防或逆转的新疗法的发展做出贡献 胰腺癌患者的骨骼肌浪费。总体而言，这项行政补充提案寻求 通过开发有关疼痛评估的全面培训课程来增强ROCMSK​​计划 和肌肉骨骼条件下的管理。通过教学教学，沉浸式动手培训， 体验式学习机会，以及在胰腺中关注疼痛评估的学员的增加 癌症模型，这种补充旨在弥合跨学科肌肉科学培训的差距 使未来的研究人员能够解决骨科条件下疼痛的复杂问题。