Interdisciplinary Clinical Advances and Research Excellence in TMDs (ICARE 4 TMDs) Collaborative

TMD 跨学科临床进展和卓越研究 (ICARE 4 TMD) 协作

• 批准号: 10829180
• 负责人: SUNIL D KAPILA
• 金额: $ 31.2万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2024-09-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10829180
• 关键词: Acceleration; Address; Area; Basic Science; Biological Markers; Chronic; Clinical; Collaborations; Complex; Core Facility; Deglutition; Development; Diagnosis; Diagnostic; Discipline; Disease; Diverse Workforce; Eating; Educational workshop; Ensure; Fatigue; Female; Fibromyalgia; Funding; Goals; Grant; Headache; Health Care Costs; Heterogeneity; Individual; Infrastructure; Institution; Irritable Bowel Syndrome; Knowledge; Low Back Pain; Machine Learning; Maps; Mentors; Modeling; Musculoskeletal; Musculoskeletal Diseases; Nature; Neurology; Outcome; Pain; Pathway interactions; Patient Care; Patients; Peer Review; Periodicals; Peripheral; Phase; Population; Program Development; Protocols documentation; Publications; Quality of life; Regenerative Medicine; Research; Research Personnel; Research Priority; Research Project Grants; Sampling; Science; Speech; Structure; Talents; Temporomandibular Joint; Temporomandibular Joint Disorders; Training; Training Programs; Transcend; Workforce Development; biobank; career development; clinical application; clinical care; clinical translation; comorbidity; data sharing; debilitating pain; disorder prevention; evidence base; improved; innovation; multiple omics; new technology; novel; novel diagnostics; novel strategies; novel therapeutics; organizational structure; palliative; patient advocacy group; patient oriented; prevent; psychological distress; rational design; research and development; sound; success; symposium

Project Summary / Abstract The long-term goal of our Interdisciplinary Clinical Advances and Research Excellence in Temporomandibular Disorders (ICARE 4 TMDs) Collaborative is to provide a robust framework to undertake a cohesive and comprehensive national interdisciplinary exploration into TMDs and comorbid conditions. TMDs are a constellation of heterogenous disorders involving the masticatory musculature, the TMJ, and associated structures, afflicting 5 to 10% of US population with annual healthcare costs of ~$4 billion. A substantial proportion of patients also present with systemic comorbidities such as headaches and fibromyalgia. Because of their unknown etiopathogenesis, the diagnosis and therapies for TMDs remain non-specific. Consequently, patients often tolerate debilitating pain and their inability to undertake essential functions such as eating and speech impacts quality of life and contributes to psychological distress. Identifying factors that cause or predispose individuals to TMDs will enable early recognition and guide the design of rational therapies, but achieving this goal requires research and clinical applications across traditional boundaries. The boundaries that limit progress in understanding or treating TMDs encompass the translational gap between discovery science and clinical applications, and between the several scientific disciplines - from musculoskeletal to pain science to regenerative medicine. To address these major gaps in knowledge and clinical care, ICARE 4 TMDs Collaborative will establish research priorities and funding and workforce development mechanisms that intentionally integrate these scientific and patient care domains. Given this primary goal, we have developed a sound conceptual model for a national Collaborative that will be further refined, detailed, and structured during the planning phase. The outcome of this planning grant is to establish a responsive administrative and operational structure; engage scholars and mentors to utilize their expertise for integrated research and workforce development; and define criteria and protocols for funding of interdisciplinary projects and career development programs. These objectives will be achieved by (1) planning the implementation of integrated bridging science from basic to clinical in pain and neurology, musculoskeletal disorders, regenerative medicine, and biomarkers; and (2) map and launch a robust and innovative workforce development program for training diverse multi-faceted scholars and clinicians with capabilities of integrating novel technologies and approaches towards accelerating discoveries and delivery of individualized interdisciplinary patient care. This application leverages multi-institutional intellectual talent and expertise of funded investigators / mentors from within and outside the field, established infrastructure and core facilities, and training programs. The application is highly responsive to the FOA due to its truly encompassing, interdisciplinary and integrated approach to dissecting TMDs for improved and targeted patient care, and because it provides a compelling forward-looking framework for a comprehensive and vibrant TMD Collaborative.

项目摘要 /摘要 我们跨学科临床进步和颞下颌研究卓越研究的长期目标 疾病（ICARE 4 TMD）协作是提供一个强大的框架来进行凝聚力和 全面对TMD和合并条件的国家跨学科探索。 TMD是一个 涉及咀嚼肌肉，TMJ和相关的异质疾病星座 结构，每年约40亿美元的医疗保健费用折磨美国人口的5％至10％。实质性 患者的比例还表现出系统合并症，例如头痛和纤维肌痛。因为 在其未知的疗法发生中，TMD的诊断和疗法仍然非特异性。最后， 患者通常会忍受衰弱的疼痛及其无法发挥基本功能，例如饮食和 言语影响生活质量，并导致心理困扰。识别导致或 容易患者对TMD的易感性将使早期认可并指导理性疗法的设计，但 实现这一目标需要跨传统边界的研究和临床应用。边界 这限制了理解或治疗TMD的进展，包括发现之间的翻译差距 科学和临床应用以及几个科学学科之间 - 从肌肉骨骼到疼痛 再生医学科学。为了解决知识和临床护理方面的这些主要差距，ICARE 4 TMD 协作将建立研究重点，资金和劳动力发展机制 故意整合这些科学和患者护理领域。鉴于这一主要目标，我们已经开发了 国家合作的合理概念模型，该模型将在期间进一步完善，详细和结构 计划阶段。这项计划赠款的结果是建立响应迅速的行政和 操作结构；吸引学者和导师，以利用其专业知识进行综合研究和 劳动力发展；并定义资金跨学科项目和职业的标准和协议 开发计划。这些目标将通过（1）计划实施集成 从疼痛和神经病学，肌肉骨骼疾病，再生医学中的基础科学桥接科学， 和生物标志物； （2）绘制并启动一项强大而创新的劳动力发展计划，用于培训 多方面的学者和临床医生具有整合新技术和方法的能力 旨在加速发现并提供个性化的跨学科患者护理。此应用程序 利用来自内部和 在现场，建立的基础设施和核心设施以及培训计划。该应用程序高度 由于其真正涵盖，跨学科和综合方法的剖析，对FOA的响应敏感 用于改进和有针对性的患者护理的TMD，并且因为它提供了令人信服的前瞻性框架 进行全面且充满活力的TMD协作。