Implantable Transducer Systems for Auditory Prostheses

用于听觉假体的植入式换能器系统

• 批准号: 10825738
• 负责人: Karl Grosh
• 金额: $ 63.16万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10825738
• 关键词: Accelerometer; Acoustic Stimulation; Acoustics; Adoption; Affect; Age; Appearance; Auditory Prosthesis; Auditory system; Behavior; Bilateral Hearing Loss; Cadaver; Calibration; Cochlea; Cochlear Implants; Communication; Cosmetics; Critical Pathways; Cues; Deposition; Devices; Dimensions; Ear; Electronics; Elements; Engineering; Environmental Wind; European; Exhibits; External Ear; Face; Female; Film; Floor; Goals; Hearing; Hearing Aids; Human; Implant; Individual; Inherited; Intervention; Language Development; Letters; Location; Longevity; Mechanics; Middle Ear Implant; Motion; Noise; Operative Surgical Procedures; Output; Patients; Performance; Pharmacologic Substance; Population; Preparation; Procedures; Process; Prosthesis; Quality of life; Research; Research Personnel; Rotation; Safety; Sampling; Sensorineural Hearing Loss; Signal Transduction; Speech Perception; Sports; Surgical Disarticulation; System; Temporal bone structure; Testing; Theoretical model; Thinness; Tissues; Transducers; Translations; Tympanic membrane; Unilateral Hearing Loss; United States; Use Effectiveness; Weight; Work; analog; battery recharging; bone; conditioning; design; effectiveness evaluation; experience; external ear auricle; force sensor; hearing impairment; hearing restoration; implantation; implanted sensor; improved; integrated circuit; male; meetings; microphone; middle ear; middle ear fluid; milligram; minimally invasive; novel; performance tests; pressure; printed circuit board; prosthesis wearer; seal; sensor; sound; subcutaneous; usability; vibration; wireless

PROJECT SUMMARY: In this application, we seek to design, fabricate, and test implantable, packaged accelerometers that sense incoming sound by transducing the motion of the middle ear (ME) bones (ossicles). We will test the performance of these devices using benchtop calibration and quantification tests as well as using acoustic stimulation of accelerometers implanted in cadaveric temporal bone preparations. We seek to create a device that meets the stringent geometric, acoustic, weight, and power requirements for prostheses by using a multi- resonant (multi-band) piezoelectric-micro-electro-mechanical systems (piezo-MEMS) sensor co-designed with an application specific integrated circuit (ASIC) with addressable filtering and amplifying circuitry. A novel flip- chip packaging strategy is proposed which can deliver a 5-milligram piezo-MEMS-ASIC packaged device by eliminating the need for printed circuit board mounting. State-of-the-art thin piezoelectric film materials and deposition will be explored to further reduce the device size and improve performance. Separate, component- level piezo-MEMS die and ASIC testing in combination with system-level testing in a benchtop setting will enable characterization of the complete system. Tested sensor systems will be implanted in male and female cadaveric temporal bone samples, and the acoustic sensitivity and noise floor characterized. We will consider locations along the ossicular chain to reduce device impact on the ME mechanics, ease surgical implantation (minimize invasiveness), and maximize sensitivity (as the accelerometer is sensitive to both translation and rotation). The objective of this present application is to develop implantable sensors, because accomplishing this objective is a necessary step in achieving our long-term goal of a totally implantable auditory prosthesis (e.g., hearing aids and cochlear implants with all components housed invisibly). This line of research aims to provide new implantable options to treat hearing loss, thereby increasing the number of auditory prosthesis users by enhancing the usability, safety, cosmetic appeal, and performance of the device and improving patient quality of life.

项目摘要： 在此应用程序中，我们寻求设计，制造和测试可植入的，包装的加速度计 传入的声音通过传递中耳（ME）骨骼（Ossicles）的运动。我们将测试 使用台式校准和量化测试以及使用声学 植入尸体颞骨制剂中的加速度计的刺激。我们试图创建一个设备 通过使用多种多样 共振（多波段）压电 - 微电机机电系统（压电器）传感器与共同设计的传感器 具有可寻址过滤和放大电路的特定应用集成电路（ASIC）。一个新颖的翻转 - 提出了芯片包装策略，该策略可以通过 消除对印刷电路板安装的需求。最先进的薄层压电胶片材料和 将探索沉积以进一步降低设备尺寸并提高性能。单独的组件 - 等级压电 - 模具模具和ASIC测试与台式设置中的系统级测试结合使用 实现完整系统的表征。测试的传感器系统将植入男性和女性 尸体颞骨样品以及声学敏感性和噪声底。我们会考虑的 沿骨链的位置，以减少对ME力学的设备影响，轻松手术植入 （最小化侵入性），并最大化灵敏度（因为加速度计对翻译既敏感又敏感 旋转）。本应用的目的是开发可植入的传感器，因为完成 这个目标是实现我们完全植入听觉假体的长期目标的必要步骤 （例如，助听器和人工耳蜗植入物，所有组件都无形）。这一研究旨在 提供新的可植入选择来治疗听力损失，从而增加听觉假体的数量 通过增强设备的可用性，安全性，化妆品吸引力和性能并改善用户 病人的生活质量。