MyPEEPS Mobile Plus: A Multi-Level HIV Prevention Intervention for Young MSM

MyPEEPS Mobile Plus：针对年轻 MSM 的多层次 HIV 预防干预措施

基本信息

批准号：
10818851
负责人：
Robert Garofalo
金额：
$ 116.46万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-21 至 2028-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10818851
关键词：
18 year old AIDS prevention Address Adherence Age Awareness Behavior Therapy Caring Cellular Phone Clinic Communities Computers Data Data Collection Disparity Education Electronics Enrollment Epidemic Face Family Feedback HIV HIV diagnosis HIV risk Health Personnel Incidence Intervention Latino Logistics Manuals Mediation Methods Participant Persons Population Predisposition Prevention program Principal Investigator Privatization Provider Public Health Randomized, Controlled Trials Reach, Effectiveness, Adoption, Implementation, and Maintenance Recommendation Research Risk Risk Behaviors Risk Reduction Rural Sampling Sampling Studies Sexual Health Sexual Partners Sexually Transmitted Diseases Structure Tablets Testing Time United States Youth barrier to care black men who have sex with men care outcomes condoms cost digital efficacy evaluation efficacy testing emotion regulation epidemiologic data ethnic disparity ethnic diversity ethnic minority evidence base experience future implementation geographic disparity group intervention high risk iterative design mHealth member men who have sex with men minority stress peer pre-exposure prophylaxis preventive intervention primary outcome psychoeducation psychoeducational racial disparity racial diversity racial minority response satisfaction scale up sexual health intervention side effect skills social stigma theories tool treatment arm uptake virtual young men who have sex with men

项目摘要

PROJECT SUMMARY Men who have sex with men (MSM), especially young Black and Latino MSM, have the highest rates of HIV diagnoses in the United States (US), illustrating the need for efficacious HIV prevention tools for these populations. In response to the burgeoning HIV epidemic in young MSM (YMSM), our study team adapted the theory-driven, group-level, evidence-based MyPEEPS intervention for diverse YMSM (R34MH079707; PI: Garofalo) into an mHealth intervention, MyPEEPS Mobile, to overcome challenges of an in-person group intervention. MyPEEPS Mobile is a sexual health intervention delivered through peer avatars whose personal backgrounds and sexual risk scenarios are composites derived from formative research among YMSM, which identified personal, family-based, and relational challenges influencing sexual health. The MyPEEPS Mobile Trial data have shown evidence of efficacy, feasibility, acceptability, and high satisfaction by participants 13-18 years of age. Despite very promising results, pre-exposure prophylaxis (PrEP) initiation to date over the course of the study has been extremely low in our sample (3%), which we partially attribute to a dearth of information on PrEP content in MyPEEPS Mobile and the very young age (13-18 years) of our study participants, for whom PrEP was not approved at the time of data collection. In response, our study team proposes to expand MyPEEPS Mobile to develop MyPEEPS Mobile Plus, a multi-level intervention comprised of MyPEEPS Mobile with added PrEP content (based upon expert advisory and youth feedback) + PrEP E-Peer Navigation to overcome the challenges of PrEP initiation, adherence, and persistence among YMSM. Peer navigation is an evidence-based, widely recommended intervention for reaching youth and MSM for HIV-related care outcomes, with evidence of acceptability among racial/ethnic minority YMSM for PrEP. Peer navigation addresses common reasons for failing to begin or maintain PrEP use, including low perceived risk, structural or logistic barriers to care engagement, and anticipated side effects. Relative to in-person and group-based HIV prevention programs, behavioral interventions with digital and virtual components can have vast reach and present unique potential to rapidly scale delivery to very large and hidden groups. Therefore, we propose to conduct a randomized controlled trial to test the efficacy of MyPEEPS Mobile Plus (a multi-level intervention comprised of MyPEEPS Mobile + PrEP E-Peer Navigation) for promoting initiation, adherence, and persistence of PrEP and decreased HIV risk behavior in YMSM. Building upon our team’s demonstrated ability to enroll large numbers of young racially and ethnically diverse YMSM and extensive experience developing mobile health interventions, the proposed study will test the efficacy of this expanded, multi-level mobile HIV prevention intervention emphasizing PrEP. If efficacious, it will increase PrEP initiation, adherence, and persistence and decrease overall HIV risk in diverse YMSM in the US.

项目摘要与男性发生性关系的男性（MSM），尤其是年轻的黑人和拉丁裔MSM，艾滋病毒率最高在美国（美国）的诊断，说明了对这些有效预防艾滋病毒预防工具的需求人群。为了回应年轻MSM（YMSM）中的hiv艾滋病毒流行，我们的研究团队适应了理论驱动的，基于循证的基于循证的mypeeps对潜水员YMMM的干预（R34MH079707; PI：：加法洛（Garofalo）进行MHealth干预措施Mypeeps Mobile，以克服面对面的挑战 mypeeps Mobile是通过同伴化身提供的性健康干预措施背景和性风险情景是源自YMSM之间形成性研究的复合材料，确定的个人，基于家庭和关系挑战会影响性健康。 mypeeps手机试验数据显示了参与者的效率，可行性，可接受性和高满意的证据13-18 年龄。尽管结果非常有希望，但预防前预防（PREP）倡议迄今为止我们的样本中的研究非常低（3％），我们部分归因于信息死亡关于MyPeeps手机的准备内容以及我们研究参与者的年龄很小（13-18岁）在数据收集时未批准PREP。作为回应，我们的学习团队提议扩展 mypeeps手机以开发mypeeps移动plus，这是MyPeeps的多级干预带有添加准备内容的移动（根据专家咨询和青年反馈） +准备电子站导航克服YMSM之间的准备计划，坚持和持久性的挑战。同行导航是一种基于证据的，广泛建议的干预措施，用于接触青年和MSM与HIV相关的护理结果，有证据表明种族/族裔少数族裔YMSM的准备。同行导航解决未开始或维持准备使用的常见原因，包括低感知风险，结构性或护理参与和预期副作用的逻辑障碍。相对于面对面和基于团体的艾滋病毒预防计划，数字和虚拟组件的行为干预措施可能具有广泛的影响力，并且具有迅速扩展到非常大而隐藏的群体的独特潜力。因此，我们建议进行随机对照试验以测试mypeeps Mobile Plus的效率（多层干预 MyPeeps Mobile + PrEP电子站导航的积累）用于促进主动性，依从性和 YMSM中PREP和改善HIV风险行为的持续性。以我们团队的表现能力为基础招募大量的年轻年轻人和种族多样化的YMSM以及发展的丰富经验移动健康干预措施，拟议的研究将测试这种扩展的多层移动艾滋病毒的效率预防干预强调准备。如果高效，它将增加准备倡议，依从性和美国潜水员YMSM的持久性和降低艾滋病毒的总体风险。