A Data Coordinating Center for ENCODE

ENCODE 数据协调中心

基本信息

批准号：
10804988
负责人：
J. Michael Cherry
金额：
$ 49.28万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-01 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10804988
关键词：
Archives Area Biological Biological Assay Biomedical Research Cells Cloud Service Communities Complement Computer Analysis Computer software Data Data Coordinating Center Data Element Data Provenance Development Disease Documentation Electronic Mail Elements Encyclopedias Genomics Goals Gold Health Human Human Characteristics Human Genome Internet Investigation Laboratories Metadata Methods Modeling Participant Procedures Process Production Provider Public Health Quality Control Records Reproducibility Research Research Personnel Resources Sampling Services Specific qualifier value Structure Students Technology Tissues Update Validation Visualization Work Writing biological research central database complex data computerized data processing data analysis pipeline data integration data management data resource data standards data submission data warehouse design distributed data empowerment experience genome browser genomic data meetings outreach repository service organization social media tool verification and validation webinar

项目摘要

Project Summary The goals of the ENCODE Data Coordinating Center (DCC) is to support the ENCODE Consortium by defining and establishing a strategy that connects all participants to the data and by creating avenues of access that distribute these data to the greater biological research community. The ENCODE Consortium brings together laboratories that generate complex data types via experimental assays with laboratories that integrate these unique data using computational analyses to discover how chromosomal elements function together to define human cells and tissues. The DCC's participation enhances the data created by these laboratories through the creation of structured procedures for the verification and validation of all submitted data and providing processes for the documentation of metadata that describe each biological sample and assay method. To facilitate access to all the data created the DCC will construct a state of the art data warehouse. The DCC will design and development robust software to enhance the data submission and unified data processing pipelines, the organization and access to metadata and the data warehouse. In addition, we will develop and maintain the ENCODE Portal that will be the primary entry point to the wealth of experimentally determined information as well as results of computational analyses. The Portal will integrate these data resources and make them available via enhanced search and browsing capabilities. Tools will be implemented to aid discovery by both experienced bioinformaticians and naïve laboratory staff. The DCC will evolve into a substantial service organization allowing biomedical research to take full advance of the ENCODE results. To this end the DCC will provide documentation via many media including written documentation, video tutorials, webinars, and meeting presentations. The DCC, DAC, production laboratories and AWG will be tightly woven together to create the ENCODE Consortium.

项目摘要编码数据协调中心（DCC）的目标是通过定义来支持编码财团并建立一种将所有参与者连接到数据并创建访问途径的策略将这些数据分配给更大的生物学研究界。编码财团汇集了通过与实验室进行实验测定来生成复杂数据类型的实验室使用计算分析的唯一数据，以发现染色体元素如何共同起作用以定义人类细胞和组织。 DCC的参与增强了这些实验室创建的数据创建结构化程序，以验证和验证所有提交的数据并提供元数据记录的过程，描述了每个生物样品和测定方法。到促进访问所有创建的数据DCC将构建最先进的数据仓库的状态。 DCC会设计和开发强大的软件以增强数据提交和统一数据处理管道，组织以及访问元数据和数据仓库。此外，我们将发展和维护编码门户，这将是实验确定的财富的主要入口处信息以及计算分析的结果。该门户将集成这些数据资源，并通过增强的搜索和浏览功能使它们提供。将实施工具以帮助经验丰富的生物信息学家和幼稚的实验室工作人员的发现。 DCC将演变成一个实质性的服务组织允许生物医学研究全面促进编码结果。到 DCC将通过许多媒体提供文档，包括书面文档，视频教程，网络研讨会和会议演讲。 DCC，DAC，生产实验室和AWG将被紧密编织共同创建编码财团。