Biostatistics and Bioinformatics Core

生物统计学和生物信息学核心

• 批准号: 10704044
• 负责人: Yu Shyr
• 金额: $ 20.55万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-07 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10704044
• 关键词: Animals; Bioinformatics; Biometry; Biostatistics Core; Breast; Clinical; Clinical Research; Collaborations; Conceptions; Data; Data Analyses; Databases; Development; Ensure; Experimental Designs; Human Resources; Immunophenotyping; Informatics; Laboratories; Longevity; Manuscripts; Methods; Participant; Pathology; Pilot Projects; Quality Control; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Sample Size; Service provision; Statistical Data Interpretation; Tissues; Work; Writing; anticancer research; career; data quality; exome sequencing; experimental study; malignant breast neoplasm; member; multidimensional data; programs; research and development; sound; transcriptome sequencing

PROJECT SUMMARY/ABSTRACT: BIOSTATISTICS AND BIOINFORMATICS CORE The Biostatistics and Bioinformatics Core (BBC) will support all four full projects. Additionally, all Developmental Research Program pilot projects and Career Enhancement Program applications will receive support from the BBC. Detailed and specific biostatistical and bioinformatic analysis plans are provided for each specific aim/sub- aim within each project. Sample size for each primary experiment is computed to provide high power to detect clinically or biologically relevant effects. Each project will include RNA-seq data analysis and whole-exome seq data analysis. For these high-dimensional data analyses, steps will be taken to ensure raw data quality; the unified method described in the Research Strategy will be applied to assess quality of the sequencing data before statistical analysis. BBC support is required for all Breast SPORE studies, with biostatisticians and bioinformaticians from this core assigned to each project. Core personnel have worked and will continue to work closely with project leaders to ensure the core provides state-of-the-art statistical/bioinformatic support.

项目摘要/摘要：生物统计学和生物信息学核心 生物统计学和生物信息学核心（BBC）将支持所有四个完整的项目。此外，所有发展 研究计划试点项目和职业增强计划申请将获得 英国广播公司为每个特定目标/子 - 瞄准每个项目。计算每个主要实验的样本量以提供高功率来检测 临床或生物学上相关的效果。每个项目都将包括RNA-seq数据分析和全异位SEQ 数据分析。对于这些高维数据分析，将采取步骤以确保原始数据质量；这 研究策略中描述的统一方法将用于评估测序数据的质量 统计分析之前。所有乳腺孢子研究都需要BBC支持，生物统计学家和 来自该核心的生物信息学家分配给每个项目。核心人员已经工作并将继续工作 与项目负责人紧密联系，以确保核心提供最先进的统计/生物信息学支持。