Core 3: Biostatistics and Bioinformatics

核心3：生物统计学和生物信息学

• 批准号: 10443611
• 负责人: Yu Shyr
• 金额: $ 28.95万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-09 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10443611
• 关键词: Bioinformatics; Biometry; Cancer Center; Clinical Research; Collaborations; Conceptions; Data; Data Analyses; Databases; Development; Ensure; Experimental Designs; Human; Human Resources; Laboratory Animals; Longevity; Malignant neoplasm of gastrointestinal tract; Manuscripts; Methods; Mus; Participant; Pathology; Quality Control; Reporting; Research Design; Research Personnel; Research Project Grants; Sample Size; Service provision; Time; Tissues; Work; Writing; anticancer research; data quality; epidemiology study; gastrointestinal; member; molecular imaging; power analysis; research and development; sound; translational study; Bioinformatics; Biometry; Cancer Center; Clinical Research; Collaborations; Conceptions; Data; Data Analyses; Databases; Development; Ensure; Experimental Designs; Human; Human Resources; Laboratory Animals; Longevity; Malignant neoplasm of gastrointestinal tract; Manuscripts; Methods; Mus; Participant; Pathology; Quality Control; Reporting; Research Design; Research Personnel; Research Project Grants; Sample Size; Service provision; Time; Tissues; Work; Writing; anticancer research; data quality; epidemiology study; gastrointestinal; member; molecular imaging; power analysis; research and development; sound; translational study

PROJECT SUMMARY/ABSTRACT: Biostatistics and Bioinformatics Core The purpose of the Biostatistics and Bioinformatics Core (BBC) is to provide professional expertise in biostatistics and bioinformatics for all Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal (GI) Cancer projects, investigators, and participants. Functions provided by this core include development of experimental designs, power analysis and sample size estimation, data quality control, statistical/bioinformatics analysis and interpretation of findings, and collaboration on presentation of results. To achieve these functions, the core director and core members are constantly available to investigators, with key biostatisticians and bioinformaticians assigned to each project, and all are in regular contact with the project and core leaders. The primary objectives of the BBC are: 1. To provide study design and review all laboratory, animal, translational, epidemiological, and clinical studies including feasibility assessment, power analysis, and sample size estimation; 2. To collaborate in project data analysis including bioinformatic pre-processing analysis, interpretation of results, and the writing of final study reports and manuscripts; 3. To work with the Tissue Pathology and Cellular Analysis Core and Mouse and Human Molecular Imaging Core in the development of research project databases, to maintain data quality control and to ensure timely data capture; 4. To develop and evaluate statistical/bioinformatic methods for experimental design and data analysis. BBC support is required in all VICC GI Cancer SPORE studies, with biostatisticians and bioinformaticians assigned to each project. Core personnel have worked and will continue to work closely with project leaders to ensure the core provides state-of-the-art statistical /bioinformatic support.

项目摘要/摘要：生物统计学和生物信息学核心 生物统计学和生物信息学核心（BBC）的目的是提供专业知识 胃肠道（GI）癌症中所有范德比尔特 - 伊格兰癌中心孢子的生物统计学和生物信息学 项目，调查人员和参与者。该核心提供的功能包括实验的开发 设计，功率分析和样本量估计，数据质量控制，统计/生物信息学分析和 研究结果的解释以及有关结果的合作。为了实现这些功能，核心 董事和核心成员不断为调查人员，主要的生物统计学家和 分配给每个项目的生物信息学家，所有这些都与该项目和核心领导者进行了定期联系。 BBC的主要目标是： 1。提供研究设计和审查所有实验室，动物，转化，流行病学和临床 包括可行性评估，功率分析和样本量估计的研究； 2。在项目数据分析中进行合作，包括生物信息学预处理分析，解释 结果，以及最终研究报告和手稿的写作； 3。与组织病理学和细胞分析核心以及小鼠以及人分子成像一起工作 研究项目数据库开发的核心，维持数据质量控制并确保 及时的数据捕获； 4。开发和评估用于实验设计和数据分析的统计/生物信息学方法。 在所有VICC GI癌症孢子研究中都需要BBC支持，生物统计学家和生物信息学家 分配给每个项目。核心人员已经工作，并将继续与项目负责人紧密合作 确保核心提供最先进的统计 /生物信息学支持。