Mechanistic and Bioinformatics Core

机制和生物信息学核心

基本信息

批准号：
10642595
负责人：
Jordi Ochando
金额：
$ 48.27万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-06-01 至 2028-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10642595
关键词：
Address Animals Bioinformatics Biological Assay Biometry Cells Cellular Assay Clinical Communication Computer software Custom Data Data Analyses Data Set Data Storage and Retrieval Ensure Epigenetic Process Equipment and supply inventories Experimental Designs Flow Cytometry Gene Expression Genes Head Human Image Immune Immunity Immunologist In Vitro Infrastructure International Investigation Laboratories Laboratory Research Medicine Metabolic Pathway Metabolism Mus Netherlands Organ Transplant Research Procedures Protocols documentation Records Reproducibility Research Personnel Sampling Standardization System Testing Therapeutic Training Transplantation data exploration data handling data integration data management data pipeline epigenome experience experimental study human error in silico in vivo large datasets medical schools monocyte multiple data types multiple omics next generation sequencing professor programs success therapeutic target transcription factor transcriptomics

项目摘要

SUMMARY – CORE C Trained immunity is characterized by pronounced changes in the epigenome, gene expression, metabolism, and cell dynamics. The investigators associated with this Program Project will perform comprehensive studies on trained immunity in the context of transplantation. To safeguard the appropriate implementation of trained immunity assays across the different projects, we have established a Mechanistic and Bioinformatics Core (Core C). Core C will operate at Mount Sinai and be directed by Dr. Jordi Ochando, an internationally recognized transplant immunologist and one of the founders of trained immunity in organ transplantation research. The Core team will provide expertise and in-house optimized protocols to profile immune cells and biologically validate promising therapeutic targets. Importantly, this Core will also safeguard bioinformatics and biostatistics analyses and general data management and storage. Lastly, Core C will implement and manage Labguru, a laboratory management system used to track samples, record, and share protocols and data, and keep inventory.

摘要 - 核心C 受过训练的免疫力的特征是表观基因组，基因表达，代谢和细胞动力学。与该计划项目相关的调查人员将对在移植的背景下受过训练的免疫力。维护适当的训练在不同项目中的免疫测定，我们建立了机械和生物信息学核心（核心C）。 Core C将在西奈山（Mount Sinai）运作，并由国际上的Jordi Ochando博士执导公认的移植免疫学家和器官移植中受过训练的免疫学的创始人之一研究。核心团队将提供专业知识和内部优化方案，以介绍免疫细胞和生物学验证有希望的治疗靶标。重要的是，该核心还将保护生物信息学和生物统计学分析以及一般数据管理和存储。最后，核心C将实施和管理 Labguru，一种实验室管理系统，用于跟踪样本，记录和共享协议和数据，以及保持库存。