Engagement Core

参与核心

基本信息

批准号：
10704662
负责人：
MONICA G. RIVERA-MINDT
金额：
$ 761.18万
依托单位：
NORTHERN CALIFORNIA INSTITUTE/RES/EDU
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-30 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10704662
关键词：
Acculturation Address Adult Alzheimer&apos s Disease Alzheimer’s disease biomarker Amyloid Amyloid beta-Protein Appointment Biological Biological Factors Biological Markers Black race Blood Vessels Clinic Clinical Clinical Trials Cognitive Communities Dedications Dementia Disclosure Disparate Disparity Education Effectiveness Elderly Equity Ethnic Origin Etiology Evaluation Exclusion Criteria Frequencies Funding Goals Health Disparities Research Health Priorities Hematological Disease Image Impaired cognition Incentives Individual Language Latinx Linguistics Magnetic Resonance Imaging Measures Medical Mentors Methods Participant Persons Population Group Positron-Emission Tomography Psychological Factors Public Health Recommendation Remunerations Research Research Methodology Research Personnel Role Sampling Site Social Network System Training Triage Trust Underrepresented Populations Update Work career cohort community based participatory research community engaged research community organizations community partnership community science comorbidity cultural competence dementia risk demographics depressive symptoms digital eligible participant evidence base expectation health disparity improved innovation low socioeconomic status neuroimaging psychologic public health priorities recruit recruitment science screening social adversity social culture sociocultural determinant success tau Proteins translational engagement vascular cognitive impairment and dementia

项目摘要

Dementia disparities are a major and rapidly escalating public health threat. For instance, Black and Latinx adults are up to three times as likely to develop Alzheimer’s disease (AD) compared to non-Latinx whites (NLW), yet they remain greatly underrepresented in research. Further, underrepresented populations (URPs; e.g., Black, Latinx; low SES) also bear a disparate burden of biological and sociocultural vulnerabilities that confer increased dementia risk, but dementia etiologies and the role of such vulnerabilities remain poorly understood. In addition, community-engaged research (CER) is an evidence-based approach for successful URP recruitment, but has lacked scalability for broad implementation. Further, the lack of an ethnoculturally/linguistically diverse, culturally competent dementia workforce may further exacerbate these challenges. Thus, the 2019 update to the National Plan to Address AD and the NIA Advisory Council (NOT-AG-18-047) have recommended the prioritization of Health Disparities research in AD. ADNI4’s Engagement Core will address these urgent priorities through: 1) increasing the engagement of underrepresented populations in ADNI4; 2) cultivating a diverse, culturally competent workforce to work with URPs; and 3) investigating ethnocultural disparities in dementia. To this end, the Engagement Core will achieve these aims by deploying a scalable, intensive, and culturally-informed CER approach for ~20,000+ individuals (50-60% from URPs) to complete the digital screener to identify 4,000 participants with AD blood biomarkers, followed by either in-person (n = 500; 50-60% URPs) or remote (remainder of the 20,000 not enrolled in clinic) longitudinal evaluations. This Core will work closely with Project 1 and the other ADNI4 Cores to support their aims and assure the full and immersive participation of URPs in all study components. Our comprehensive, multi-faceted plan includes: (1) a CER-based Digital Engagement Campaign; (2) a Diverse Engagement Team, including Community Research Liaisons to promote URP recruitment through community-based engagement with local community-based organizations (CBOs), and Community Research Navigators to promote retention/engagement via providing navigational support to all participants and study partners; (3) Diversity Recruitment Hub Sites (n = 20) that will receive additional fiscal and instrumental support for URP recruitment; (4) Community Partnerships (e.g., national and local CBOs) that will be facilitated through our Community-Science Partnership Board; (5) Culturally-informed Methods to address barriers to URP recruitment/engagement (e.g., trust, burden) and provide better ethnocultural characterization of the sample; and (6) Workforce Training to enhance cultural competency of all ADNI investigators and staff, and provide mentored training to a total 15 ADNI4 Scholars over five years (URP trainees and early career investigators). The activities and goals detailed in this Core are deemed essential for the overarching success of ADNI-4 and have important implications for advancing recruitment science, informing clinical trials, addressing the urgent AD workforce shortage of culturally-competent researchers, and improving public health.

痴呆症差异是一个主要且迅速升级的公共卫生威胁。例如，黑人和拉丁裔成年人与非Latinx白人（NLW）相比，发展阿尔茨海默氏病（AD）的可能性长达三倍他们在研究中的人数远远不足。此外，代表性不足的人口（URP；例如，黑色， Latinx;低SES）还具有不同的生物学和社会文化脆弱性的燃烧，会议增加了痴呆症的风险，但痴呆症的病因和这种脆弱性的作用仍然很少了解。此外，社区参与研究（CER）是成功招募URP的基于证据的方法，但已有缺乏广泛实施的可扩展性。此外，缺乏民族文化/语言多样的文化有能力的痴呆症劳动力可能会进一步加剧这些挑战。那，2019年对国家的更新计划向广告和NIA咨询委员会（NOT-AG-18-047）讲话，已建议优先考虑 AD的健康差异研究。 ADNI4的参与核心将通过以下方式解决这些紧急优先事项：1）增加代表人群在ADNI4中的参与； 2）在文化上种植潜水员有能力与URP合作的劳动力； 3）研究痴呆症的民族文化差异。为此，参与核心将通过部署可扩展，密集和文化的CER来实现这些目标约20,000+个人（来自URP的50-60％）的方法完成数字筛选器以识别4,000 AD血液生物标志物的参与者，其次是面对面（n = 500; 50-60％URP）或遥控器（在未参加诊所的20,000名未参加的20,000名）纵向评估中。该核心将与项目紧密合作 1和其他ADNI4核心支持其目标，并确保URP的全部和身临其境的参与研究组件。我们全面的，多面的计划包括：（1）基于CER的数字参与活动; （2）一个多元化的参与团队，包括社区研究联络人，以促进URP 通过与当地社区组织（CBO）的社区参与以及社区研究导航员通过向所有人提供导航支持来促进保留/参与参与者和学习伙伴；（3）多样性招聘中心站点（n = 20）将获得额外的财政和对URP招聘的工具支持；（4）社区伙伴关系（例如国家和地方CBO）将通过我们的社区科学合作伙伴委员会准备；（5）解决文化的方法 URP招聘/参与度的障碍（例如，信任，伯恩）并提供更好的民族文化特征样本（6）劳动力培训以增强所有ADNI调查人员和员工的文化能力，并为五年来总共提供了15个ADNI4学者的指导培训（URP受训者和早期职业）调查人员）。该核心中详细介绍的活动和目标对于总体成功至关重要 ADNI-4的作品，并对推进招聘科学，为临床试验提供了重要意义紧急的广告劳动力缺乏具有文化能力的研究人员，并改善了公共卫生。