The Role of Structural and Interpersonal Discrimination on Latina Mother and Child Immune Pathways

结构性和人际歧视对拉丁裔母婴免疫途径的作用

• 批准号: 10679388
• 负责人: Rebeca Alvarado Harris
• 金额: $ 4.06万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-15 至 2025-05-14
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10679388
• 关键词: 5 year old; Acculturation; Address; Adult; Award; Biological; Birth; Child; Child health equity; Childhood; Chronic; Chronic Disease; Cohort Studies; Communities; Critical Pathways; DNA Methylation; Data; Data Collection; Depressed mood; Development; Development Plans; Disadvantaged; Discrimination; Disease; Emotional; Equity; Evidence based intervention; Family; Fellowship; Fetal Development; Foundations; Growth; Health; Health Care Costs; Human Development; Immigrant; Immune; Immune system; Immunologic Markers; Impairment; Inequity; Inflammation; Inflammatory; Interleukin-6; Knowledge; Latina; Latina Population; Latinx; Latinx population; Life; Link; Literature; Longevity; Low Birth Weight Infant; Maternal and Child Health; Measures; Mediating; Mental Depression; Mentorship; Modeling; Mothers; NR3C1 gene; Neighborhoods; Nurses; Obesity; Outcome; Pathway interactions; Personal Satisfaction; Plasma Proteins; Population Group; Pregnancy; Psychosocial Stress; Regulator Genes; Reporting; Research; Research Personnel; Research Priority; Risk; Role; Safety; Scientist; Social Environment; Social support; Strategic Planning; Stress; Subgroup; TNF gene; Time; Training; Woman; analytical method; career development; childhood adversity; cohort; community engagement; depressive symptoms; early childhood; emotional functioning; experience; health determinants; health disparity; immunoregulation; in utero; intergenerational; knowledge integration; low socioeconomic status; maternal stress; migration; perceived discrimination; perinatal period; pre-clinical; pregnant; preventive intervention; research and development; segregation; skills; social; social health determinants; stressor; theories

ABSTRACT Interpersonal and structural discrimination can be transferred from mother to child by heightening maternal stress during a child’s early sensitive developmental windows: in-utero and early childhood. As Latinx families acculturate to the US, maternally experienced discrimination may become biologically embedded in a mother’s young child, increasing her child’s vulnerability to chronic inflammatory conditions (e.g., depression, obesity) across the lifespan. Dysregulated immune pathways may provide biological explanations for early childhood health conditions that increase intergenerationally, including chronic childhood diseases and socioemotional difficulties. Yet, the multi-level contextual influences, such as cumulative discrimination, which may drive a trajectory of worsened maternal and child health remain elusive. This proposed study will examine the degree to which maternal experiences of discrimination may induce a pro-inflammatory state in both mother and child via immune dysregulation—a critical pathway linking stress to chronic disease. This proposal integrates theoretical frameworks (Biological Embedding of Childhood Adversity Model and Social Safety Theory) to understand the relationship between discrimination and immune pathways during pregnancy and early childhood through two specific aims: Aim 1a: Determine the extent to which interpersonal and structural discrimination is associated with maternal immune profiles (20 inflammatory plasma proteins) during pregnancy; 1b: Explore if maternal acculturation moderates the relationships between interpersonal and structural discrimination and maternal immune profiles. Aim 2a: Explore whether maternal experiences of interpersonal and structural discrimination are associated with a child’s immune regulation (DNA methylation of immune-regulatory genes, TNF-a, IL-6, NR3C1) and socioemotional functioning at 3-5 years old; 2b: Explore whether maternal social support moderates relationships between maternal interpersonal and structural discrimination and child immune regulation and socioemotional functioning. The accompanying career development plan will provide a foundation to a) advance my knowledge in early child socioemotional development; b) develop skills and knowledge integrating biological mechanisms within social contexts related to human development; c) develop skills in community engagement strategies and primary data collection in Latinx populations; d) develop advanced skills in quantitative analytical methods. My strong mentorship team will guide me throughout this award. Collectively, the career development and research plan will support my growth as an independent nurse scientist examining social and biological determinants of maternal and child health in Latinx families. This proposal aligns with NINR’s Strategic Plan to identify multi-level social determinants of health that disadvantage specific population groups. Understanding interactions between biological mechanisms and social contexts early in the developmental cascade may inform preventive interventions that counteract the emotional and biological sequalae of discrimination in Latina mothers and their young children.

抽象的 可以通过增加材料压力将人际交往和结构歧视从母亲转移到孩子 在孩子早期敏感的发育窗口中：In-Utero和幼儿。作为拉丁裔家庭 养殖对美国的主要歧视可能会在生物学上嵌入到母亲的 幼儿，增加了孩子对慢性炎症状况的脆弱性（例如抑郁，肥胖） 整个生命周期。失调的免疫病可能会为幼儿提供生物学解释 综合性增加的健康状况，包括慢性儿童疾病和社会情感 困难。然而，多层次的上下文影响，例如累积歧视，这可能会推动 恶作剧和儿童健康的轨迹仍然难以捉摸。这项拟议的研究将研究该程度 哪种歧视经历可以通过 免疫失调 - 将应激与慢性疾病联系起来的关键途径。该提案集成了理论 框架（儿童逆境模型和社会安全理论的生物嵌入）了解 通过两个 具体目的：目标1a：确定与人际交往和结构歧视相关的程度 怀孕期间具有母体免疫谱（20种炎症性血浆蛋白）； 1B：探索是否有母亲 培养适中 免疫轮廓。 AIM 2A：探索孕产妇的人际交往和结构歧视的经历 与儿童的免疫调节基因TNF-A，IL-6， NR3C1）和3-5岁的社会情感功能； 2B：探索产妇社会支持是否适中 母校际交往和结构歧视与儿童免疫调节之间的关系以及 社会情感功能。参与的职业发展计划将为A提供基础 提高我对早期儿童社会情感发展的知识； b）发展技能和知识整合 与人类发展有关的社会环境中的生物学机制； c）社区的发展技能 拉丁人种群中的参与策略和主要数据收集； d）发展了高级技能 定量分析方法。我强大的精明团队将指导我整个奖项。共同 职业发展和研究计划将支持我作为一名独立护士科学家的成长 拉丁裔家庭的母亲和儿童健康的社会和生物学决定者。该提议与Ninr的 战略计划，以确定特定于灾难人群的多层次社会决定者。 在发展早期了解生物学机制与社会环境之间的互动 级联可以告知预防性干预措施，以抵消 拉丁裔母亲及其小孩的歧视。