Preconceptional health of Latinas and its association with child adiposity

拉丁裔的孕前健康状况及其与儿童肥胖的关系

基本信息

批准号：
10188517
负责人：
ANNA MARIA SIEGA-RIZ
金额：
$ 60.06万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-18 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10188517
关键词：
5 year old Accounting Acculturation Address Adult Affect Age Ancillary Study Anthropometry Behavior Behavioral Biological Biological Markers Blood Pressure Body Weight Body fat Child Child Rearing Cities Clinic Visits Complex Conceptions Data Development Diet Disease Documentation Dual-Energy X-Ray Absorptiometry Eating Eating Behavior Ensure Environment Family Fatty acid glycerol esters Food Future Genetic Genetic Predisposition to Disease Health Health Status Health behavior Height High Density Lipoprotein Cholesterol High Prevalence High birth weight infant Hispanic Community Health Study/Study of Latinos Hispanics Home Hyperphagia Income Infant Insulin Intervention Intervention Studies Latina Latino Life Life Style Link Low income Maternal Health Measures Mental Health Metabolic dysfunction Minority Groups Modeling Mothers National Health and Nutrition Examination Survey Not Hispanic or Latino Obesity Overweight Parents Perinatal Personal Satisfaction Physical activity Prevalence Protocols documentation Psychological Stress Public Health Randomized Controlled Trials Recording of previous events Reproductive History Research Rewards Risk Risk Factors Role Social Behavior Sociology Standardization Time Triglycerides United States Visit Weight Weight Gain Woman cardiometabolic risk cardiometabolism cardiovascular health cohort depressive symptoms design fasting glucose feeding food environment improved maternal obesity metabolic profile middle childhood mother nutrition novel obesity development obesity in children obesity risk offspring offspring obesity prenatal prepregnancy prevent prospective psychosocial recruit reproductive sedentary lifestyle sleep behavior sociodemographics therapy development waist circumference

项目摘要

Abstract: Hispanic children have a higher prevalence of overweight/obesity than their non-Hispanic counterparts. Perinatal maternal health status and lifestyle behaviors are recognized as important risk factors for childhood obesity. Pre-pregnancy maternal obesity is linked to higher infant birth weight and increased risk of offspring obesity. The maternal diet and metabolic profile during preconception has been shown to adversely affect the subsequent health of the offspring, including the development of obesity. However, the data are scarce for Hispanics from various backgrounds and limited, in general, due to the lack of standardized documentation of preconception health. The Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a cohort of 16,415 adults (including 3,801 women 18-44y) from four U.S. cities, is the largest health study of Hispanics/Latinos in the US. Baseline data, including cardiometabolic markers and diet, were collected from 2008 to 2011, and reproductive history is being collected at visit 2 from October 2014 to 2017. Hence, HCHS/SOL offers a unique opportunity to prospectively investigate the role of preconceptional maternal health status (cardiometabolic biomarkers and diet) on the development of childhood obesity and to understand drivers of overeating, such as food reward-related behaviors and psychological stress of women as predictors of child feeding practices and weight. This ancillary study proposes to recruit 440 mother-child dyads; these are women of reproductive age with a child (ages 3-7y) born since the baseline examination to assess child's weight, height and adiposity (total fat mass as measured by DEXA), eating and other lifestyle behaviors, and women's food reward-related behaviors. We propose to identify early modifiable determinants of child's weight and adiposity status that are not attributable to the genetic environment. This is a novel use of an existing cohort to answer very timely and important research questions that have the ability to contribute to the development of intervention studies during this very critical time period in the lifecycle of both the mother and child for the Hispanic population.

抽象的：西班牙裔孩子的超重/肥胖症患病率高于非西班牙裔同行。围产期孕产妇的健康状况和生活方式行为被认为是儿童肥胖的重要危险因素。怀孕前母亲肥胖与较高的肥胖有关婴儿的出生体重和后代肥胖的风险增加。孕产妇饮食和代谢曾经看法期间的特征已显示出对随后的健康状况的不利影响后代，包括肥胖的发展。但是，西班牙裔的数据很少由于缺乏标准化，从各种背景和有限预选健康的文件。西班牙裔社区健康研究/研究拉丁裔（HCHS/SOL），来自美国四个的16,415名成年人（包括3,801名女性18-44岁）的队列城市是美国西班牙裔/拉丁美洲人最大的健康研究。基线数据，包括从2008年到2011年收集了心脏代谢标记和饮食，生殖历史是从2014年10月到2017年的访问中收集。因此，HCHS/SOL提供了独特的前瞻性调查孕妇健康状况的作用的机会（心脏代谢生物标志物和饮食）关于儿童肥胖的发展和了解暴饮暴食的驱动力，例如与食物奖励相关的行为和心理妇女的压力是儿童喂养做法和体重的预测因素。这项辅助研究提议招募440个母子二元组；这些是有孩子生殖年龄的妇女（3-7岁）自从基线检查以来出生，以评估孩子的体重，身高和肥胖（DEXA测量的总脂肪量），饮食和其他生活方式行为以及女性食物与奖励相关的行为。我们建议确定儿童体重的早期可修改决定因素和肥胖状态不是遗传环境。这是一种新颖的用途现有的队列，可以回答具有能力的非常及时且重要的研究问题为在这个非常关键时期的干预研究的发展做出贡献对于西班牙裔人口而言，母子和孩子的生命周期。