Risk Factors for Alzheimer's Disease Among Latinos: Relationships Between Cardiovascular Disease Risk, Acculturation, Small Vessel Disease, and Alzheimer's Biomarkers

拉丁裔阿尔茨海默病的危险因素：心血管疾病风险、文化适应、小血管疾病和阿尔茨海默病生物标志物之间的关系

• 批准号: 10351716
• 负责人: Ariana Stickel
• 金额: $ 15.4万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2022-08-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10351716
• 关键词: Accounting; Acculturation; Address; Adoption; Age; Aging; Alzheimer' s Disease; Alzheimer' s Disease Pathway; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Alzheimer’s disease biomarker; American; Amyloid; Amyloid beta-Protein; Ancillary Study; Attenuated; Biological; Biological Markers; Brain; Brain Injuries; Cerebrovascular system; Clinical; Cognition; Cognitive; Cognitive aging; Communities; Data; Dementia; Development; Diabetes Mellitus; Elderly; Enrollment; Estrogens; Face; Gender; Glial Fibrillary Acidic Protein; Goals; Healthcare; Hispanic Community Health Study/Study of Latinos; Hispanic Populations; Impaired cognition; Incidence; Income; Individual; Intervention; Investigation; Latina; Latina Population; Latino; Latino Population; Latinx; Lead; Life Expectancy; Light; Link; Longevity; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mediating; Memory; Mexican Americans; Microvascular Dysfunction; National Institute on Aging; Neurocognitive; Outcome; Performance; Physical activity; Plasma; Population; Prevalence; Public Health; Race; Research; Resources; Risk; Risk Factors; Role; Sampling; Scientist; Study of Latinos; Testing; Training; United States; Woman; base; biopsychosocial; black men; black women; cardiovascular disorder risk; cardiovascular health; cerebrovascular pathology; clinical care; cognitive change; dementia risk; epidemiologic data; ethnic difference; ethnic minority; good diet; health disparity; male; men; middle age; mild cognitive impairment; neurofilament; novel; programs; psychosocial; racial and ethnic; sex; social culture; stem; tau Proteins; tool; white matter

PROJECT SUMMARY Latinos/as are a large and growing segment of the United States older adult population and are at increased risk for Alzheimer’s disease and related dementias (ADRDs) compared to non-Latino/a Whites. Evidence suggests that Latinos/as are particularly susceptible to ADRD in the presence of cardiovascular disease risk factors (CVDRFs). Several other factors (e.g., sex, acculturation, Alzheimer’s biomarkers) may influence the degree to which CVDRFs are linked to ADRD risk. For example, our own preliminary data suggest that Latina women with elevated CVDRFs are more likely to have mild cognitive impairment (MCI), an intermediate stage between healthy cognition and ADRD, than men. Interestingly, less acculturation (i.e., maintaining Latino/a culture and less adoption of Anglo-American culture) has been associated with better cardiovascular health, particularly among women, but pilot data has linked lower acculturation to poorer cognition. Finally, Alzheimer’s biomarkers are becoming more accessible but have not been thoroughly investigated among Latinos/as who are more likely to have mixed Alzheimer’s and cerebrovascular pathology (brain damage linked to poor cardiovascular health) as opposed to pure Alzheimer’s pathology. The overarching goal of the proposed study is to develop a comprehensive characterization of cognitive impairment and ADRD risk among middle-age and older Latinos/as. To achieve this, the proposed project will incorporate psychosocial (i.e., acculturation) and biological [i.e., CVDRFs, small vessel disease (a marker of cerebrovasculature), and Alzheimer’s biomarkers] factors to study longitudinal cognitive change among Latinos/as 50+ years old. More specifically, the proposed project will examine detailed cognitive data from the Study of Latinos- Investigation of Neurocognitive Aging (SOL-INCA), SOL-INCA MRI (magnetic resonance imaging), and SOL-INCA AD (Alzheimer’s disease), ancillary studies to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). In aim 1 we seek to characterize gender-specific associations between acculturation and MCI, and test if CVDRFs underly the link between acculturation and MCI status in over 6,000 Latinos/as. In aim 2 we will use gender-specific analysis to determine if small vessel disease accounts for the relationship between CVDRFs and MCI/dementia status (while accounting for acculturation); projected n = 2,400. In aim 3, we will examine whether acculturation or Alzheimer’s biomarkers influence the relationships between small vessel disease and MCI/dementia status; projected n = 2,400. The proposed K08 project will provide the candidate the tools necessary to continue investigating Latino/a cognitive aging and ADRD risk through the National Institute on Aging’s Health Disparities Framework as an independent clinical scientist.

项目摘要 拉丁美洲人/是美国老年人的大型且不断增长的部分，并且正在增加 与非latino/a白人相比，阿尔茨海默氏病和相关痴呆症（ADRDS）的风险。证据 表明在存在心血管疾病风险的情况下，拉丁美洲/地区特别容易受到ADRD的影响 因素（CVDRF）。其他几个因素（例如，性，适应性，阿尔茨海默氏症的生物标志物）可能会影响 CVDRF与ADRD风险相关的程度。例如，我们自己的初步数据表明拉丁裔 CVDRF升高的女性更可能患有轻度认知障碍（MCI），这是一个中级阶段 在健康的认知和ADRD之间，比男人。有趣的是，较少的适应性（即维持拉丁裔/a 文化和对盎格鲁裔文化的采用较少）与更好的心血管健康有关 特别是在妇女中，但试点数据已将较低的培养基化与认知较差联系在一起。最后，阿尔茨海默氏症 生物标志物变得越来越易于​​访问，但在拉丁美洲人中尚未进行彻底调查/ 更可能患有混合阿尔茨海默氏症和脑血管病理学（脑损伤与差有关 心血管健康）与纯阿尔茨海默氏病的病理相反。拟议研究的总体目标 是在中年和 较旧的拉丁裔/as。为了实现这一目标，拟议的项目将纳入社会心理（即适应）和 生物学[即CVDRFS，小血管疾病（脑桥梁的标志）和阿尔茨海默氏症的生物标志物] 研究拉丁美洲人/50岁以上的纵向认知变化的因素。更具体地说，提议 项目将检查来自拉丁裔研究的详细认知数据 - 神经认知衰老 （Sol-Inca），Sol-Inca MRI（磁共振成像）和Sol-Inca AD（阿尔茨海默氏病）， 西班牙裔社区健康研究/拉丁裔研究（HCHS/SOL）的辅助研究。在目标1中，我们寻求 表征适应和MCI之间的性别特定关联，并测试链接下的CVDRF 在6,000多个拉丁美洲裔/AS的培养和MCI状态之间。在AIM 2中，我们将使用特定于性别的分析来 确定小血管疾病是否解释了CVDRF和MCI/痴呆状态之间的关系 （在考虑培养的同时）；预计n = 2,400。在AIM 3中，我们将研究培养或 阿尔茨海默氏症的生物标志物影响小血管疾病与MCI/痴呆状态之间的关系； 预计n = 2,400。拟议的K08项目将为候选人提供继续的工具 通过国家衰老健康研究所调查拉丁裔/认知衰老和ADRD风险 作为独立临床科学家的差异框架。