Engagement Core

参与核心

• 批准号: 10495153
• 负责人: MONICA G. RIVERA-MINDT
• 金额: $ 780.79万
• 依托单位: NORTHERN CALIFORNIA INSTITUTE/RES/EDU
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10495153
• 关键词: Acculturation; Address; Adult; Alzheimer' s Disease; Alzheimer’s disease biomarker; Amyloid; Amyloid beta-Protein; Appointment; Biological; Biological Markers; Black race; Blood Vessels; Clinic; Clinical; Clinical Trials; Cognitive; Communities; Dementia; Disclosure; Education; Effectiveness; Elderly; Ethnic Origin; Etiology; Evaluation; Exclusion Criteria; Frequencies; Funding; Goals; Health Disparities Research; Hematological Disease; Image; Immersion; Impaired cognition; Incentives; Individual; Language; Latinx; Linguistics; Magnetic Resonance Imaging; Measures; Medical; Mentors; Methods; Participant; Persons; Positron-Emission Tomography; Public Health; Remunerations; Research; Research Methodology; Research Personnel; Role; Sampling; Science; Site; Social Network; System; Time; Training; Triage; Trust; Underrepresented Populations; Update; Ursidae Family; Work; base; career; cohort; community based participatory research; community engaged research; community partnership; community science; comorbidity; cultural competence; dementia risk; demographics; depressive symptoms; digital; eligible participant; evidence base; expectation; health disparity; improved; innovation; low socioeconomic status; neuroimaging; psychologic; public health priorities; recruit; social adversity; social culture; success; tau Proteins; vascular cognitive impairment and dementia

Dementia disparities are a major and rapidly escalating public health threat. For instance, Black and Latinx adults are up to three times as likely to develop Alzheimer’s disease (AD) compared to non-Latinx whites (NLW), yet they remain greatly underrepresented in research. Further, underrepresented populations (URPs; e.g., Black, Latinx; low SES) also bear a disparate burden of biological and sociocultural vulnerabilities that confer increased dementia risk, but dementia etiologies and the role of such vulnerabilities remain poorly understood. In addition, community-engaged research (CER) is an evidence-based approach for successful URP recruitment, but has lacked scalability for broad implementation. Further, the lack of an ethnoculturally/linguistically diverse, culturally competent dementia workforce may further exacerbate these challenges. Thus, the 2019 update to the National Plan to Address AD and the NIA Advisory Council (NOT-AG-18-047) have recommended the prioritization of Health Disparities research in AD. ADNI4’s Engagement Core will address these urgent priorities through: 1) increasing the engagement of underrepresented populations in ADNI4; 2) cultivating a diverse, culturally competent workforce to work with URPs; and 3) investigating ethnocultural disparities in dementia. To this end, the Engagement Core will achieve these aims by deploying a scalable, intensive, and culturally-informed CER approach for ~20,000+ individuals (50-60% from URPs) to complete the digital screener to identify 4,000 participants with AD blood biomarkers, followed by either in-person (n = 500; 50-60% URPs) or remote (remainder of the 20,000 not enrolled in clinic) longitudinal evaluations. This Core will work closely with Project 1 and the other ADNI4 Cores to support their aims and assure the full and immersive participation of URPs in all study components. Our comprehensive, multi-faceted plan includes: (1) a CER-based Digital Engagement Campaign; (2) a Diverse Engagement Team, including Community Research Liaisons to promote URP recruitment through community-based engagement with local community-based organizations (CBOs), and Community Research Navigators to promote retention/engagement via providing navigational support to all participants and study partners; (3) Diversity Recruitment Hub Sites (n = 20) that will receive additional fiscal and instrumental support for URP recruitment; (4) Community Partnerships (e.g., national and local CBOs) that will be facilitated through our Community-Science Partnership Board; (5) Culturally-informed Methods to address barriers to URP recruitment/engagement (e.g., trust, burden) and provide better ethnocultural characterization of the sample; and (6) Workforce Training to enhance cultural competency of all ADNI investigators and staff, and provide mentored training to a total 15 ADNI4 Scholars over five years (URP trainees and early career investigators). The activities and goals detailed in this Core are deemed essential for the overarching success of ADNI-4 and have important implications for advancing recruitment science, informing clinical trials, addressing the urgent AD workforce shortage of culturally-competent researchers, and improving public health.

痴呆症差异是一个重大且迅速升级的公共卫生威胁，例如，黑人和拉丁裔成年人。 与非拉丁裔白人 (NLW) 相比，罹患阿尔茨海默病 (AD) 的可能性高达三倍，但 他们在研究中的代表性仍然严重不足。此外，代表性不足的人群（URP；例如黑人、 拉丁裔（社会经济地位低）也承受着不同的生物和社会文化脆弱性负担，这些负担增加了 痴呆症风险，但痴呆症的病因和此类脆弱性的作用仍然知之甚少。 社区参与研究 (CER) 是成功招募 URP 的一种基于证据的方法，但 此外，缺乏种族文化/语言多样性、文化多样性。 有能力的痴呆症劳动力可能会进一步加剧这些挑战，因此，2019 年国家更新。 解决 AD 问题的计划和 NIA 咨询委员会 (NOT-AG-18-047) 建议优先考虑 ADNI4 参与核心的健康差异研究将通过以下方式解决这些紧迫的优先事项：1) 增加 ADNI4 中代表性不足的人群的参与；2) 培养多元化的文化群体； 与 URP 合作的有能力的劳动力；以及 3) 调查痴呆症的种族文化差异。 参与核心将通过部署可扩展、密集且文化丰富的 CER 来实现这些目标 为约 20,000 多名个人（50-60% 来自 URP）提供方法来完成数字筛选，以识别 4,000 具有 AD 血液生物标志物的参与者，然后是现场（n = 500；50-60% URP）或远程 （其余 20,000 名未参加临床）纵向评估将与项目密切合作。 1 和其他 ADNI4 核心支持他们的目标并确保 URP 全面、身临其境地参与所有活动 我们全面的、多方面的计划包括：(1) 基于 CER 的数字参与。 活动；(2) 多元化参与团队，包括社区研究联络员，以促进 URP 通过与当地社区组织 (CBO) 进行社区接触进行招聘，以及 社区研究导航员通过向所有人提供导航支持来促进保留/参与 参与者和研究合作伙伴；(3) 将获得额外财政的多元化招聘中心站点（n = 20） 以及对 URP 招募的工具性支持；(4) 社区伙伴关系（例如国家和地方社区组织） （5）基于文化的解决方法 URP 招募/参与的障碍（例如信任、负担）并提供更好的民族文化特征 (6) 员工培训，以提高所有 ADNI 调查员和工作人员的文化能力， 并在五年内为总共 15 名 ADNI4 学者提供指导培训（URP 学员和早期职业生涯 本核心中详述的活动和目标被认为对于总体成功至关重要。 ADNI-4 的研究成果，对于推进招募科学、为临床试验提供信息、解决 具有文化能力的研究人员的 AD 劳动力紧迫短缺，并改善公共卫生。