Medication Adherence Among HIV+ Hispanics

艾滋病毒西班牙裔患者的药物依从性

• 批准号: 7339422
• 负责人: MONICA G. RIVERA-MINDT
• 金额: $ 17.95万
• 依托单位: FORDHAM UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-10 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7339422
• 关键词: AIDS/HIV problem; Accounting; Acculturation; Address; Adherence; Adult; Affect; Affinity; African American; Anti-Retroviral Agents; Arts; Attenuated; Behavior; Biological; Biometry; Caribbean natives; Caribbean region; Complement; Development; Development Plans; Dimensions; Dominican; Education; Educational Curriculum; Electronics; English Language; Epidemic; Epidemiology; Ethnic Origin; Exhibits; Funding; Future; HIV; Health Status; Hispanics; Individual Differences; Intervention; Knowledge; Lead; Linguistics; Literature; Longitudinal Studies; Measurement; Mediating; Mediator of activation protein; Mentored Patient-Oriented Research Career Development Award; Mentors; Minority Groups; Modeling; Monitor; New York; Not Hispanic or Latino; Outcome; Participant; Pharmaceutical Preparations; Poverty; Prospective Studies; Proxy; Puerto Rican; Reading; Research; Research Methodology; Research Personnel; Research Training; Risk; Risk Factors; Sampling; Social Impacts; Socioeconomic Status; Subgroup; Techniques; Technology; Training; base; career; design; health disparity; health literacy; innovation; literacy; low socioeconomic status; medication compliance; method development; migration; neuropsychological; novel; programs; psychological outcomes; social; social model

DESCRIPTION (provided by applicant): Career Development Plan: The applicant is requesting 5 years of funding through the Mentored Patient- Oriented Research Career Development Award (K23-PA-05-143) to develop her into an independent investigator in HIV/AIDS health disparities research, with an emphasis on investigating the sociocultural aspects of antiretroviral adherence and biologic outcomes with HIV+ Hispanics. Career Development Methods: A coordinated, mentored curriculum of didactic and research training and study development is proposed. Dr. Rivera Mindt will receive guidance from her mentors; will complete formal coursework and training in sociocultural and adherence research, HIV/AIDS biologic outcomes, advanced research methodology, biostatistics and epidemiology, and the ethical conduct of research; and participate in related local seminars and national scientific meetings. Scientific Background: The Hispanic community is the largest and fastest growing racial/ethnic minority group in the U.S., and is disproportionately affected by the HIV/AIDS epidemic and myriad social risk factors. However, little is known regarding how sociocultural factors impact antiretroviral adherence in this group. The proposed study will examine the sociocultural determinants of antiretroviral adherence in a sample of HIV+ Hispanic and non-Hispanic white adults using electronic medication monitoring technology. Specific Research Aims: 1) To determine whether sociocultural factors are individually associated with antiretroviral adherence and biological outcomes among HIV+ Hispanics; 2) To evaluate the impact of culture on antiretroviral adherence and biological outcomes, after accounting for the impact of social risk factors; and 3) To examine whether sociocultural "risk factors" mediate the effect of ethnicity on antiretroviral adherence, and to examine explicitly the effects of neuropsychological (NP) functioning in this association. Research Methods: Dr. Rivera Mindt will lead a study of antiretroviral adherence utilizing advanced, electronic medication monitoring technology for 100 HIV+ Hispanic and 50 non-Hispanic white adults. Significance: This study will enhance our understanding of antiretroviral adherence among HIV+ Hispanics & lead to innovative, culturally tailored interventions to increase antiretroviral adherence in this group. This project will also lead to a larger-scale, longitudinal study of sociocultural factors in antiretroviral adherence among this historically under-served group.

DESCRIPTION (provided by applicant): Career Development Plan: The applicant is requesting 5 years of funding through the Mentored Patient- Oriented Research Career Development Award (K23-PA-05-143) to develop her into an independent investigator in HIV/AIDS health disparities research, with an emphasis on investigating the sociocultural aspects of antiretroviral adherence and biologic outcomes with HIV+ Hispanics.职业发展方法：提出了一项协调的，指导的教学和研究培训和研究开发课程。里维拉·明特（Rivera Mindt）博士将获得她的导师的指导；将完成社会文化和依从性研究，艾滋病毒/艾滋病生物结果，先进的研究方法论，生物统计学和流行病学以及研究道德行为的正式课程和培训；并参加相关的当地研讨会和国家科学会议。科学背景：西班牙裔社区是美国最大，最快的种族/族裔少数群体，受HIV/AIDS流行病和无数社会风险因素的影响不成比例。但是，关于社会文化因素如何影响该组抗逆转录病毒的依从性，知之甚少。拟议的研究将使用电子药物监测技术研究HIV+西班牙裔和非西班牙裔白人成年人样本中抗逆转录病毒依从性的社会文化决定因素。具体研究目的：1）确定社会文化因素是否与艾滋病毒+西班牙裔抗逆转录病毒依从性和生物学结果分别相关； 2）评估文化对社会风险因素的影响后，培养对抗逆转录病毒依从性和生物学结果的影响； 3）检查社会文化的“风险因素”是否介导种族对抗逆转录病毒依从性的影响，并明确检查该关联中神经心理学（NP）的作用。研究方法：Rivera Mindt博士将利用100 HIV+西班牙裔和50名非西班牙裔白人成年人的先进的电子药物监测技术进行抗逆转录病毒依从性研究。意义：这项研究将增强我们对HIV+西班牙裔抗逆转录病毒遵守的理解，并导致创新的，具有文化量身定制的干预措施，以增加该组的抗逆转录病毒依从性。该项目还将导致对这一历史悠久的群体中抗逆转录病毒依从性的社会文化因素的纵向研究。