Joint Biology Consortium Resource-based Center

联合生物学联盟资源中心

• 批准号: 10684880
• 负责人: Peter A Nigrovic
• 金额: $ 89.3万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-11 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10684880
• 关键词: ATAC-seq; Acceleration; Adult; Ally; Antigens; Archives; Arthritis; Award; Bioinformatics; Biology; Biometry; Boston; CRISPR screen; Cellular Indexing of Transcriptomes and Epitopes by Sequencing; Child; Childhood; Communities; Consent; Consultations; Country; Custom; Cytometry; Data; Dedications; Disease; Education; Electronic Health Record; Environment; Feasibility Studies; Fostering; Genotype; Grant; Health; Heart; Hospitals; Human; Individual; Inflammatory Arthritis; Infrastructure; Investments; Joints; Leadership; Link; Longevity; Medicine; Mentors; Methodology; Methods; Modeling; National Institute of Arthritis, and Musculoskeletal, and Skin Diseases; Orthopedics; Patients; Pediatric Hospitals; Phage ImmunoPrecipitation Sequencing; Phenotype; Pilot Projects; Positioning Attribute; Program Evaluation; Proteins; Publications; Research; Research Personnel; Resources; Review Committee; Rheumatology; Sampling; Scanning; Services; Source; System; Systemic Lupus Erythematosus; Techniques; Technology; Tissues; Translational Research; United States; Update; Visit; Woman; Work; Workforce Development; analytical tool; biobank; career; cohort; design; diversity and inclusion; innovation; interest; meetings; member; next generation sequencing; novel strategies; operation; professor; programs; prospective; recruit; sample collection; service delivery; single-cell RNA sequencing; statistical service; success; synergism; tool; transcriptomics; translational barrier; translational scientist; web portal

PROJECT SUMMARY/ABSTRACT - Overall Breaking down barriers to translational research is the key to finding new approaches to inflammatory arthritis and related diseases in adults and children. Four years ago, with P30 support, we built the Joint Biology Consortium (JBC), a shared infrastructure based at the Brigham and Women’s Hospital and Boston Children’s Hospital, to accelerate the work of an arthritis-focused Research Community now spanning 18 research centers across the United States and abroad. Based on the success of the JBC, we propose to continue and expand the fundamental design of three Cores designed around the shared needs of JBC members to enhance the efficiency of existing studies, facilitate innovation, and foster junior investigators. 1. The Administrative Core is the organizational heart of the JBC, coordinating operations and cultivating the scientific potential of the JBC research network, coordinated through the JBC Web Portal. The JBC Synergy Meeting and Visiting Professor program promote scientific interchange, the JBC Workforce Development Group promotes a diverse and inclusive research pipeline, and the JBC Enrichment Program incorporates innovations from award-winning mentors to support JBC Young Investigators via grant aims review, mentoring, and 12 yearly JBC Microgrants of $5,000 to facilitate utilization of JBC services for pilot and feasibility studies. 2. The Human Biosamples Core provides “one-stop shopping” for adult and pediatric biospecimens essential to research in arthritis and related diseases. The HBC leverages 19 distinct sources of samples. The new JBC Recruitment Core provides targeted prospective recruitment from over 100,000 consented individuals based on phenotype and, in many cases, genotype to build a unified pipeline for biospecimens across the lifespan. 3. The Cellular Systems Core provides resource- and expertise-intensive tools for arthritis research. Next- generation sequencing tools include single-cell RNAseq, CITE-seq, ATAC-seq, T-scan, PhIP-seq, and spatial transcriptomics, while protein-based services include CyTOF, tissue mass cytometry, and custom Luminex, all analyzed with assistance and education from the new JBC Bioinformatics Core. Spearheaded by committed investigators and mentors Director PI/PD Dr. Peter Nigrovic and Associate Director and Co-PI Dr. Elizabeth Karlson, the JBC spurs innovation within a deliberately inclusive and highly collaborative network of senior and junior investigators, enabling the Joint Biology Consortium to continue to grow as an engine of translational research in adult and pediatric arthritis and related disease.

项目摘要/摘要 - 总体 打破翻译研究的障碍是寻找新方法的炎症性关节炎的关键 以及成人和儿童的相关疾病。四年前，在P30的支持下，我们建立了联合生物学 财团（JBC），位于杨百翰和妇女医院和波士顿儿童的共享基础设施 医院，以加快关节炎的研究社区的工作，目前跨越18个研究 美国和国外的中心。根据JBC的成功，我们建议继续 扩展围绕JBC成员共同需求的三个核心的基本设计 提高现有研究的效率，促进创新和寄养初级研究人员。 1。行政核心是JBC的组织心脏，协调操作和培养 JBC研究网络的科学潜力，通过JBC Web门户进行协调。 JBC协同作用 会议和访问教授计划促进科学互换，JBC劳动力发展 小组促进了多样化和包容性的研究管道，JBC丰富计划成立 通过屡获殊荣的导师到支持JBC年轻调查员的创新，通过Grant Aims评论，指导， 5,000美元的JBC微型货物和12年的JBC微型货车用于托管JBC服务用于试点和可行性研究的利用率。 2。人类生物样本核心为成人和小儿生物测量提供“一站式购物”至关重要 关节炎和相关疾病的研究。 HBC利用了19种不同的样本来源。新的JBC 招聘核心提供有针对性的潜在招聘 关于表型，在许多情况下是基因型，以在整个生命周期中建立统一的生物测量管道。 3。细胞系统核心为关节炎研究提供了资源和专业的密集型工具。下一个- 生成测序工具包括单细胞RNASEQ，CITE-SEQ，ATAC-SEQ，T-SCAN，PHIP-SEQ和空间 转录组学，而基于蛋白质的服务包括细胞，组织质量细胞术和自定义Luminex 通过新的JBC生物信息学核心的协助和教育进行了分析。 由犯有调查人员和导师董事PI/PD彼得·尼格罗维奇（Peter Nigrovic）博士和同事的率领 导演兼副驾驶伊丽莎白·卡尔森（Elizabeth Karlson） 高级和初级研究人员的合作网络，使联合生物联盟能够继续 作为成人和小儿关节炎以及相关疾病的转化研究引擎的发展。

项目成果

Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation.

• DOI: 10.1038/s41590-021-00928-y
• 发表时间: 2021-06
• 期刊: Nature immunology
• 影响因子: 30.5
• 作者: Cheung P;Schaffert S;Chang SE;Dvorak M;Donato M;Macaubas C;Foecke MH;Li TM;Zhang L;Coan JP;Schulert GS;Grom AA;Henderson LA;Nigrovic PA;Elias JE;Gozani O;Mellins ED;Khatri P;Utz PJ;Kuo AJ
• 通讯作者: Kuo AJ

Lifestyle and Clinical Risk Factors for Incident Rheumatoid Arthritis-associated Interstitial Lung Disease.

• DOI: 10.3899/jrheum.200863
• 发表时间: 2021-05
• 期刊: The Journal of rheumatology
• 作者: Kronzer VL;Huang W;Dellaripa PF;Huang S;Feathers V;Lu B;Iannaccone CK;Gill RR;Hatabu H;Nishino M;Crowson CS;Davis JM 3rd;Weinblatt ME;Shadick NA;Doyle TJ;Sparks JA
• 通讯作者: Sparks JA

Differential impacts of TNFα inhibitors on the transcriptome of Th cells.

• DOI: 10.1186/s13075-021-02558-z
• 发表时间: 2021-07-23
• 期刊: Arthritis research & therapy
• 影响因子: 4.9
• 作者: Ho CH;Silva AA;Tomita B;Weng HY;Ho IC
• 通讯作者: Ho IC

TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.

• DOI: 10.1371/journal.pone.0122271
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Diogo D;Bastarache L;Liao KP;Graham RR;Fulton RS;Greenberg JD;Eyre S;Bowes J;Cui J;Lee A;Pappas DA;Kremer JM;Barton A;Coenen MJ;Franke B;Kiemeney LA;Mariette X;Richard-Miceli C;Canhão H;Fonseca JE;de Vries N;Tak PP;Crusius JB;Nurmohamed MT;Kurreeman F;Mikuls TR;Okada Y;Stahl EA;Larson DE;Deluca TL;O'Laughlin M;Fronick CC;Fulton LL;Kosoy R;Ransom M;Bhangale TR;Ortmann W;Cagan A;Gainer V;Karlson EW;Kohane I;Murphy SN;Martin J;Zhernakova A;Klareskog L;Padyukov L;Worthington J;Mardis ER;Seldin MF;Gregersen PK;Behrens T;Raychaudhuri S;Denny JC;Plenge RM
• 通讯作者: Plenge RM

Immunomodulators and risk for breakthrough infection after third COVID-19 mRNA vaccine among patients with rheumatoid arthritis: A cohort study.

类风湿关节炎患者接种第三种 COVID-19 mRNA 疫苗后免疫调节剂和突破性感染的风险：一项队列研究。

• DOI: 10.1101/2023.10.08.23296717
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Schiff,AbigailE;Wang,Xiaosong;Patel,NaomiJ;Kawano,Yumeko;Kowalski,EmilyN;Cook,ClaireE;Vanni,KathleenMM;Qian,Grace;Bade,KatarinaJ;Saavedra,AleneA;Srivatsan,Shruthi;Williams,ZacharyK;Venkat,RathnamK;Wallace,ZacharyS;Sp
• 通讯作者: Sp