Center for Molecular, Cellular, and Translational Immunology

分子、细胞和转化免疫学中心

• 批准号: 8256739
• 负责人: WILLIAM R GREEN
• 金额: $ 118.21万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8256739
• 关键词: Antigens; Autoimmunity; Award; Basic Science; Biology; Biomedical Research; Centers of Research Excellence; Characteristics; Commit; Communicable Diseases; Consultations; Core Facility; Development; Disease; Doctor of Medicine; Doctor of Philosophy; Education; Ensure; Faculty; Flow Cytometry Shared Resource; Foundations; Funding; Goals; Human; Hypersensitivity; Immune response; Immune system; Immunologic Monitoring; Immunology; Infection; Inflammation; Institutes; Instruction; Investigation; Laboratories; Lung; Malignant Neoplasms; Medical center; Mentors; Mission; Molecular; Mus; National Center for Research Resources; National Institute of Allergy and Infectious Disease; Natural Immunity; Norris Cotton Cancer Center; Patient Care; Phase; Pilot Projects; Qualifying; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Services; Speed; Syndrome; Technology; Transgenic Organisms; United States National Institutes of Health; Universities; Vaccines; Vermont; base; bench to bedside; career; catalyst; congenic; immunopathology; medical schools; microbial; operation; programs; response; success; systems research; translational approach; tumor

Based on the success ofthe initial 10-year award, the ultimate goals of this COBRE renewal application are to complete the establishment at Dartmouth of a nationally recognized Center for Molecular, Cellular, and Translational Immunological Research, and to transition this COBRE Center for Immunological Research (COBRE-CIR) to an infrastructure-based, freestanding (from COBRE funding), sustainable center in five years. With the foundation of a long-standing Immunology Program, which has now been substantially enhanced by COBRE support, this proposal takes advantage of a highly interactive core of collaborative faculty at Dartmouth Medical School (DMS) and Dartmouth Hitchcock Medical Center (DHMC). With this expanded investigator base, a Phase III COBRE award will provide the resources to build the needed infrastructure to sustain the COBRE-CIR, further grow the Program, and facilitate inter-disciplinary basic science to translational immunological research. This infrastructure will include the continued mentored development of our immunlogical faculty, especially those investigators previously supported by COBRE; expansion ofthe COBRE Cores and their full integration with existing complementary cores and shared services at DMS/DHMC, particularly the Norris Cotton Cancer Center and the other Immunology and "Lung Biology" COBREs at Dartmouth and the Univesrity of Vermont; and an enhanced Pilot Projdect Program with targeting to mentored, collaborative, and/or translational/human systems research. Together with substantive Institutional commitment by DMS/DHMC, there is confidence that the strong existing cadre of investigators, already expanded and matured by the COBRE mechanism, can be further developed to complete the formation of a sustainable Center for Immunological Research that is grounded in excellent basic science investigation, embraces a translational approach to promote bidirectional bench-to-bedside application of hypothesis-driven research, and has a regional, if not also national, impact.

基于最初 10 年奖的成功，本次 COBRE 续签申请的最终目标是 在达特茅斯完成国家认可的分子、细胞和分子中心的建立 转化免疫学研究，并将 COBRE 免疫学研究中心转型 (COBRE-CIR) 发展成为一个基于基础设施的、独立的（由 COBRE 资助）、可持续发展的中心，分为五个 年。凭借长期免疫学计划的基础，该计划现已得到实质性 在 COBRE 支持的增强下，该提案利用了高度互动的协作核心 达特茅斯医学院 (DMS) 和达特茅斯希区柯克医疗中心 (DHMC) 的教师。有了这个 扩大了研究者基础，第三阶段 COBRE 奖励将提供资源来建立所需的 维持 COBRE-CIR、进一步发展该计划并促进跨学科基础的基础设施 科学到转化免疫学研究。该基础设施将包括持续指导 我们免疫学能力的发展，特别是那些以前由 COBRE 支持的研究人员； COBRE 核心的扩展及其与现有互补核心和共享核心的完全集成 DMS/DHMC 的服务，特别是 Norris Cotton 癌症中心和其他免疫学和“肺 达特茅斯大学和佛蒙特大学的“生物学”COBRE；以及增强的试点项目计划 以指导、协作和/或转化/人类系统研究为目标。连同 DMS/DHMC 的实质性机构承诺，有信心现有的强大骨干队伍 COBRE 机制已经扩大和成熟的调查员可以进一步发展 完成建立一个可持续的免疫学研究中心，该中心以优秀的 基础科学研究，采用转化方法来促进双向临床试验 假设驱动研究的应用，并且具有区域性（即使不是全国性的）影响。