Do discrimination and adversity drive the inflammatory basis of suicidal ideation in Black and Latinx young adults?

歧视和逆境是否会导致黑人和拉丁裔年轻人产生自杀意念？

基本信息

批准号：
10680405
负责人：
Jesse Walker
金额：
$ 3.84万
依托单位：
UNIVERSITY OF HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10680405
关键词：
Accounting Address Adult Affect Antiinflammatory Effect Attenuated Award Behavior Behavioral Biological Biological Markers Biological Models Biological Testing Black Populations Black race Buffers Caregivers Child Chronic Data Data Analyses Data Collection Development Discipline Discrimination Disparate Disparity Emotional Ethnic Origin Event Exposure to Feeling suicidal Fellowship Funding Goals Grant Health Immunologic Factors Immunological Models Individual Inflammation Inflammatory Inflammatory Response Knowledge Latinx Latinx population Link Literature Long-Term Effects Measurement Mediating Mediation Mediator Mental Health Methods Minority Mission Modeling National Institute on Minority Health and Health Disparities Outcome Parents Participant Pathway interactions Patient Self-Report Play Population Heterogeneity Prevalence Process Psychopathology Public Health Publications Race Reporting Research Research Methodology Research Personnel Risk Risk Factors Role Salivary Secure Security Signal Transduction Suicide System Testing Thinking Training Writing adverse childhood events adverse outcome analytical method base biological adaptation to stress biopsychosocial career cytokine doctoral student early life stress ethnic discrimination ethnic minority ethnic minority population exhaust experience health disparity hypothalamic-pituitary-adrenal axis investigator training minority children novel protective effect protective factors racial health disparity racial minority racial minority population recruit salivary assay scaffold skills statistics suicidal behavior suicidal individual suicidal risk suicide rate systemic inflammatory response theories young adult

项目摘要

PROJECT SUMMARY/ABSTRACT In recent years, the prevalence of suicidal ideation among young Black and Latinx individuals has been on the rise1,2,3 with racial/ethnic discrimination and adverse childhood events (ACEs)4,5 thought to explain this health disparity. Systemic inflammation—a product of over-activation of the body’s stress response system—has been hypothesized to play a unique predictive role in suicidal ideation development6,7,8. Experiencing racial/ethnic discrimination and ACEs can lead to systemic inflammation9,10,11—possibly accounting for suicidal ideation’s growing prevalence among young racial/ethnic minorities who experience ACEs and discrimination at disproportionate rates. Conversely, secure attachment relationships have been associated with a reduction in systemic inflammation12 and a lower risk for suicidal ideation13. The broad aim of this fellowship research is to test biological and relational mechanisms explaining suicidal ideation among racial/ethnic minority young adults, specifically examining ACEs and racial/ethnic discrimination as risk factors as well as the mediating role of systemic inflammation and the protective effects of close relationships. Chronic exposure to racial/ethnic discrimination and ACEs can lead to dysregulation of the hypothalamic- pituitary-adrenal (HPA) axis, leading to an exhausted release of proinflammatory cytokines and systemic inflammation10,14,15. Biological models identify systemic inflammation as a potential mediator of suicidal ideation given elevated levels of proinflammatory cytokines in individuals with suicidal behaviors6,8,9 Further, studies have shown ACEs and racial/ethnic discrimination can alter proinflammatory cytokine levels and signaling10,15 However, no study has attempted to investigate systemic inflammation as a mediator of suicidal ideation in adulthood nor the proposed risk or protective factors within this pathway. This proposal addresses these gaps by (a) examining whether the links between ACEs and racial/ethnic discrimination with suicidal ideation are mediated by systemic inflammation and (b) examining attachment security as a moderator. This proposal utilizes a biopsychosocial model integrating multiple levels of analysis (i.e., immunobiological, behavioral, relational). It reflects the mission of the National Institute of Minority Health and Health Disparities (NIMHD) to identify mechanisms and protective factors of disparities such that this study aims to elucidate how systemic inflammation might arise from ACEs and racial/ethnic discrimination and increase risk for suicidal ideation in young adults with emphasis on the protective effects of secure attachment relationships to uncover fundamental mechanisms of a pressing health disparity in diverse populations. Finally, this award will aid in training a young researcher seeking to understand the mechanisms associated with negative outcomes in young adults from ethnic/racial minority groups by providing necessary scaffolding toward an independent research career and opportunities for advanced research skills breadth depth of knowledge across disciplines.

项目概要/摘要近年来，黑人和拉丁裔年轻人自杀意念的流行率一直在上升种族/民族歧视和不良童年事件 (ACE)4,5 的上升1,2,3 被认为可以解释这种健康状况全身性炎症是身体应激反应系统过度激活的产物。被培养在自杀意念发展中发挥独特的预测作用6,7,8。种族/民族歧视和 ACE 可导致全身炎症9,10,11——可能是自杀的原因在经历过 ACE 和歧视的年轻种族/族裔中，观念越来越普遍离线时，安全依恋关系与减少有关。减少全身炎症 12 和降低自杀意念 13 的风险。是测试解释种族/族裔自杀意念的生物学和关系机制少数民族年轻人，特别将 ACE 和种族/民族歧视视为风险因素以及全身炎症的介导作用和密切关系的保护作用。长期暴露于种族/民族歧视和 ACE 可能导致下丘脑失调垂体-肾上腺 (HPA) 轴，导致促炎细胞因子的耗尽释放和全身炎症10,14,15。生物模型将全身炎症确定为自杀意念的潜在介质。有自杀行为的个体促炎细胞因子水平升高6,8,9进一步的研究已经表明 ACE 和种族/民族歧视可以改变促炎细胞因子水平和信号传导 10,15 然而，没有研究试图调查全身炎症作为自杀意念的中介因素。成年期或该途径中提议的风险或保护因素该提案解决了这些差距。 (a) 检查 ACE 与种族/族裔歧视与自杀意念之间的联系是否存在由全身炎症介导，并且（b）检查附件安全性作为调节剂。利用生物心理社会模型整合多个层次的分析（即免疫生物学、行为学、它反映了国家少数民族健康和健康差异研究所 (NIMHD) 的使命：确定差异的机制和保护因素，以便本研究旨在阐明如何 ACE 和系统性种族/民族歧视可能会引起炎症，并增加患病风险年轻人的自杀意念，重点是安全依恋的保护作用关系以揭示不同群体中紧迫的健康差异的基本机制最后，该奖项将有助于培训寻求了解这些机制的年轻研究人员。通过提供必要的服务，与少数族裔/种族群体的年轻人的负面结果相关为独立研究生涯提供支撑，并为高级研究技能广度提供机会跨学科的知识深度。