Do discrimination and adversity drive the inflammatory basis of suicidal ideation in Black and Latinx young adults?

歧视和逆境是否会导致黑人和拉丁裔年轻人产生自杀意念？

• 批准号: 10460970
• 负责人: Jesse Walker
• 金额: $ 3.48万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10460970
• 关键词: Accounting; Address; Adult; Affect; Anti-Inflammatory Agents; Attenuated; Award; Behavioral; Biological; Biological Markers; Biological Models; Biological Testing; Black Populations; Black race; Buffers; Caregivers; Child; Chronic; Data; Data Analyses; Data Collection; Development; Discipline; Discrimination; Emotional; Exposure to; Feeling suicidal; Fellowship; Funding; Goals; Health; Immunologic Factors; Immunological Models; Individual; Inflammation; Inflammatory; Inflammatory Response; Institutes; Knowledge; Latinx; Latinx population; Lead; Link; Literature; Long-Term Effects; Measurement; Mediating; Mediation; Mediator of activation protein; Mental Health; Methods; Minority; Mission; Modeling; Outcome; Parents; Participant; Pathway interactions; Patient Self-Report; Play; Population Heterogeneity; Prevalence; Process; Psychopathology; Public Health; Publications; Race; Reporting; Research; Research Methodology; Research Personnel; Research Project Grants; Risk; Risk Factors; Role; Salivary; Secure; Security; Suicide; System; Testing; Thinking; Training; Writing; adverse childhood events; adverse outcome; analytical method; base; biological adaptation to stress; biopsychosocial; career; cytokine; doctoral student; early life stress; ethnic discrimination; ethnic minority; ethnic minority population; exhaust; experience; health disparity; hypothalamic-pituitary-adrenal axis; investigator training; minority children; minority health disparity; novel; protective effect; protective factors; racial and ethnic; racial health disparity; racial minority; racial minority population; recruit; salivary assay; scaffold; skills; statistics; suicidal; suicidal risk; systemic inflammatory response; young adult

PROJECT SUMMARY/ABSTRACT In recent years, the prevalence of suicidal ideation among young Black and Latinx individuals has been on the rise1,2,3 with racial/ethnic discrimination and adverse childhood events (ACEs)4,5 thought to explain this health disparity. Systemic inflammation—a product of over-activation of the body’s stress response system—has been hypothesized to play a unique predictive role in suicidal ideation development6,7,8. Experiencing racial/ethnic discrimination and ACEs can lead to systemic inflammation9,10,11—possibly accounting for suicidal ideation’s growing prevalence among young racial/ethnic minorities who experience ACEs and discrimination at disproportionate rates. Conversely, secure attachment relationships have been associated with a reduction in systemic inflammation12 and a lower risk for suicidal ideation13. The broad aim of this fellowship research is to test biological and relational mechanisms explaining suicidal ideation among racial/ethnic minority young adults, specifically examining ACEs and racial/ethnic discrimination as risk factors as well as the mediating role of systemic inflammation and the protective effects of close relationships. Chronic exposure to racial/ethnic discrimination and ACEs can lead to dysregulation of the hypothalamic- pituitary-adrenal (HPA) axis, leading to an exhausted release of proinflammatory cytokines and systemic inflammation10,14,15. Biological models identify systemic inflammation as a potential mediator of suicidal ideation given elevated levels of proinflammatory cytokines in individuals with suicidal behaviors6,8,9 Further, studies have shown ACEs and racial/ethnic discrimination can alter proinflammatory cytokine levels and signaling10,15 However, no study has attempted to investigate systemic inflammation as a mediator of suicidal ideation in adulthood nor the proposed risk or protective factors within this pathway. This proposal addresses these gaps by (a) examining whether the links between ACEs and racial/ethnic discrimination with suicidal ideation are mediated by systemic inflammation and (b) examining attachment security as a moderator. This proposal utilizes a biopsychosocial model integrating multiple levels of analysis (i.e., immunobiological, behavioral, relational). It reflects the mission of the National Institute of Minority Health and Health Disparities (NIMHD) to identify mechanisms and protective factors of disparities such that this study aims to elucidate how systemic inflammation might arise from ACEs and racial/ethnic discrimination and increase risk for suicidal ideation in young adults with emphasis on the protective effects of secure attachment relationships to uncover fundamental mechanisms of a pressing health disparity in diverse populations. Finally, this award will aid in training a young researcher seeking to understand the mechanisms associated with negative outcomes in young adults from ethnic/racial minority groups by providing necessary scaffolding toward an independent research career and opportunities for advanced research skills breadth depth of knowledge across disciplines.

项目摘要/摘要 近年来，年轻的黑人和拉丁裔人的自杀观念的流行一直在 有种族/种族歧视和不良儿童事件（ACE）4,5的崛起1,2,3被认为解释了这种健康状况 差距。系统性炎症（过度激活人体压力反应系统的产物） 假设我们在自杀思想发展中发挥独特的预测作用6,7,8。经验 种族/种族歧视和王牌可能会导致全身性炎症9,10,11-可能会考虑自杀 在经历王牌和歧视的年轻种族/族裔少数群体中，构想的越来越流行 以不成比例的速度。相反，安全的依恋关系与减少有关 在系统性炎症中122和自杀想法的风险较低13。这项研究金研究的广泛目的 是测试生物学和关系机制，以解释种族/种族中的自杀思想 少数族裔年轻人，专门研究ACE和种族/种族歧视作为风险因素 以及系统性炎症的中介作用以及密切关系的受保护作用。 长期暴露于种族/族裔歧视和ACE会导致下丘脑 - 垂体 - 肾上腺（HPA）轴，导致促炎细胞因子和全身性释放 炎症10,14,15。生物学模型将系统性炎症确定为自杀思想的潜在介体 给定自杀行为的个体促炎细胞因子的水平升高6,8,9，研究 已经显示出ACE和种族/种族歧视可以改变促炎细胞因子水平和信号10,15 但是，尚无研究试图研究系统性炎症作为自杀思想的调解人 成年或该途径内提议的风险或受保护因素。该建议解决了这些差距 通过（a）检查ACES与自杀想法之间的种族/种族歧视之间的联系是否是 由全身注入和（b）检查依恋安全性作为主持人。这个建议 利用一个整合多个分析级别的生物心理社会模型（即免疫生物学，行为， 关系）。它反映了国家少数民族健康与健康差异（NIMHD）的使命 确定机制和保护分布因素，以便本研究旨在阐明如何 系统性炎症可能是由于ACE和种族/种族歧视引起的，并增加了风险 年轻人的自杀想法，重点是安全依恋的受保护作用 揭示潜水员紧迫健康差异的基本机制的关系 人群。最后，该奖项将有助于培训一名年轻的研究人员，以了解这些机制 通过提供必要 竞争独立的研究职业和高级研究技能广度的机会 跨学科的知识深度。