Drinking Water Arsenic, Blood Pressure, and Ischemic Stroke in the REGARDS Study

REGRARDS 研究中的饮用水砷、血压和缺血性中风

基本信息

批准号：
10681410
负责人：
Matthew O. Gribble
金额：
$ 11.14万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10681410
关键词：
Address Affect African American Age American Heart Association Arsenic Arsenicals Biological Markers Biology Biometry Blood Pressure Cohort Analysis Cohort Studies Communities Community of Practice Country Data Data Analyses Data Analytics Data Linkages Data Science Data Set Data Sources Development Diastolic blood pressure Doctor of Philosophy Documentation Environmental Health Epidemiology Exposure to Foundations Future Geological Survey Goals Guidelines Health Health Status Human Biology Hypertension Income Individual Ischemic Stroke Knowledge Mentors Metabolism Methodology Methods Modification National Heart, Lung, and Blood Institute Obesity Outcome Outcome Study Paper Participant Patient Recruitments Persons Population Postdoctoral Fellow Prevalence Privatization Probability Public Health Public Health Informatics Race Reasons for Geographic And Racial Differences in Stroke Recording of previous events Research Resources Risk Risk Assessment Risk Factors Sample Size Seafood Source Southeastern United States Strategic vision Stroke System Uncertainty United States United States Environmental Protection Agency Urine Visit Water Water Pollutants Water Supply Woman Work World Health Organization analytical method biracial black men burden of illness cardiometabolism cohort data analysis pipeline data integration data streams drinking water epidemiology study experience frontier geographic difference ground water hazard informatics tool innovation insight machine learning model men multiple data sources novel post stroke predictive modeling preventive intervention primary outcome response sex spatial epidemiology stroke risk tool unpublished works user-friendly water quality

项目摘要

ABSTRACT The goal of this highly interdisciplinary project, which draws on epidemiological, hydrological, and biostatistical expertise, is to use spatial data linkage to connect drinking water arsenic data (or model predictions) to cardiometabolic health outcomes in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study. The REGARDS Study is a biracial (African American and white) cohort with participants recruited from across the United States, with emphasis on the Southeastern United States. The large sample size and geographic variation in this cohort make it an ideal resource for spatial drinking water arsenic epidemiology. This proposed work will support the development and refinement of a novel data analytic pipeline, which will allow integration of multiple data streams (community water system public supply water quality data, and groundwater predictions relevant for private wells) to give epidemiological inferences about drinking water arsenic and cardiometabolic health outcomes. The primary outcomes of the study are blood pressure at the REGARDS Study baseline visit, hypertension prevalence at the REGARDS Study baseline visit, and incident ischemic stroke among participants in the REGARDS Study at risk of incident ischemic stroke at baseline. The study will consider potential differences in response to arsenic according to putative effect modifiers (e.g., sex, race). Successful completion of the project aims will not only address significant knowledge gaps about drinking water arsenic’s potential salience to cardiometabolic health in the United States, but also provide a highly innovative data analysis pipeline that can be the foundation for future drinking water health research in the United States.

抽象的这个高度跨学科项目的目标是利用流行病学、水文学和生物统计学的知识专业知识，就是利用空间数据联动，将饮用水砷数据（或模型预测）连接到中风地理和种族差异原因中的心脏代谢健康结果（问候）研究是一项混血儿（非裔美国人和白人）参与者队列。从美国各地招募，重点是美国东南部。该群体的规模和地理差异使其成为空间饮用水砷的理想资源这项拟议的工作将支持新型数据分析的开发和完善。管道，这将允许集成多个数据流（社区供水系统公共供水质量数据以及与私人水井相关的地下水预测），以提供流行病学推断饮用水砷和心脏代谢健康结果该研究的主要结果是血液。 REGARDS 研究基线访视时的压力、REGARDS 研究基线时的高血压患病率 REGRARDS 研究中存在缺血性中风风险的参与者的就诊和缺血性中风事件该研究将根据假定的情况考虑对砷反应的潜在差异。影响因素（例如性别、种族）的成功完成不仅会解决重大问题。关于饮用水砷对美国心脏代谢健康的潜在重要性的知识差距州，还提供高度创新的数据分析管道，可以成为未来饮酒的基础美国的水健康研究。