Drinking Water Arsenic, Blood Pressure, and Ischemic Stroke in the REGARDS Study

REGRARDS 研究中的饮用水砷、血压和缺血性中风

基本信息

批准号：
10515830
负责人：
Matthew O. Gribble
金额：
$ 11.14万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10515830
关键词：
Address Affect African American Age American Heart Association Arsenic Arsenicals Biological Markers Biology Biometry Blood Pressure Cohort Analysis Cohort Studies Communities Community of Practice Country Data Data Analyses Data Analytics Data Linkages Data Science Data Set Data Sources Development Diastolic blood pressure Doctor of Philosophy Documentation Environmental Health Epidemiology Exposure to Foundations Future Geological Survey Goals Guidelines Health Health Status Human Biology Hypertension Income Individual Ischemic Stroke Knowledge Mentors Metabolism Methodology Methods Modification National Heart, Lung, and Blood Institute Obesity Outcome Outcome Study Paper Participant Patient Recruitments Persons Population Postdoctoral Fellow Prevalence Privatization Probability Public Health Public Health Informatics Race Reasons for Geographic And Racial Differences in Stroke Recording of previous events Research Resources Risk Risk Assessment Risk Factors Sample Size Source Southeastern United States Strategic vision Stroke Supervision System Uncertainty United States United States Environmental Protection Agency Urine Visit Water Water Pollutants Water Supply Woman Work World Health Organization analytical method biracial black men burden of illness cardiometabolism cohort data analysis pipeline data handling data streams drinking water epidemiology study experience frontier geographic difference ground water hazard informatics tool innovation insight machine learning model men multiple data sources novel post stroke predictive modeling preventive intervention primary outcome response sex spatial epidemiology stroke risk tool unpublished works user-friendly water quality

项目摘要

ABSTRACT The goal of this highly interdisciplinary project, which draws on epidemiological, hydrological, and biostatistical expertise, is to use spatial data linkage to connect drinking water arsenic data (or model predictions) to cardiometabolic health outcomes in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study. The REGARDS Study is a biracial (African American and white) cohort with participants recruited from across the United States, with emphasis on the Southeastern United States. The large sample size and geographic variation in this cohort make it an ideal resource for spatial drinking water arsenic epidemiology. This proposed work will support the development and refinement of a novel data analytic pipeline, which will allow integration of multiple data streams (community water system public supply water quality data, and groundwater predictions relevant for private wells) to give epidemiological inferences about drinking water arsenic and cardiometabolic health outcomes. The primary outcomes of the study are blood pressure at the REGARDS Study baseline visit, hypertension prevalence at the REGARDS Study baseline visit, and incident ischemic stroke among participants in the REGARDS Study at risk of incident ischemic stroke at baseline. The study will consider potential differences in response to arsenic according to putative effect modifiers (e.g., sex, race). Successful completion of the project aims will not only address significant knowledge gaps about drinking water arsenic’s potential salience to cardiometabolic health in the United States, but also provide a highly innovative data analysis pipeline that can be the foundation for future drinking water health research in the United States.

抽象的这个高度跨学科项目的目标是借助流行病学，水文和生物统计学专业知识是使用空间数据链接将饮用水砷数据（或模型预测）连接到心脏代谢的健康成果，其原因是中风和种族差异的原因（有关）研究。这项研究是与参与者的混血儿（非裔美国人和白人）队列从美国各地招募，重点是美国东南部。大样本该队列中的大小和地理变化使其成为空间饮用水砷的理想资源流行病学。这项提出的工作将支持新的数据分析的开发和完善管道将允许多个数据流（社区供水系统公共供应水）集成质量数据和与私人井相关的地下水预测），以给出有关流行病学的推论饮用水砷和心脏代谢健康结果。该研究的主要结果是血液在研究基线访问的方面压力，在研究基线的高血压患病率参与者的参与者中的访问和事件的缺血性中风，处于异性疾病风险的研究风险基线时中风。根据推定效应修饰符（例如，性，种族）。成功完成项目目标不仅将解决重要的问题关于饮用水砷对曼联心脏代谢健康潜在显着性的知识差距国家，但还提供了高度创新的数据分析管道，这可能是未来饮酒的基础美国水健康研究。