The Influence of Vocal Loading Upon the Healing of Experimental Vocal Fold Injury

声带负荷对实验性声带损伤愈合的影响

基本信息

批准号：
10674999
负责人：
TOBIAS RIEDE
金额：
$ 18.75万
依托单位：
MIDWESTERN UNIVERSITY (GLENDALE AZ)
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10674999
关键词：
3-Dimensional Acceleration Acoustics Affect Air Movements Anatomy Animal Model Behavior Biomechanics California Cartilage Characteristics Cicatrix Collagen Communication impairment Complex Computer Models Dependence Development Disease Dose Dysphonia Elements Epithelium Female Fiber Frequencies Genetic Growth Histology Hoarseness Hormones Human Hygiene Individual Injury Investigation Laboratories Lamina Propria Laryngeal Injury Laryngeal cartilage Larynx Life Maintenance Measures Modeling Morphology Movement Mus Noise Occupational Organ Outcome Output Pathology Pattern Peromyscus Phenotype Pliability Population Procedures Process Production Property Public Health Recovery Research Role Shapes Speech Structure Study models Symptoms Testing Therapeutic Intervention Thick Time Tissues Variant Voice Work X-Ray Computed Tomography behavioral phenotyping density epithelial injury experience healing in vitro Model in vivo Model male microCT mouse model nerve supply phenotypic biomarker postnatal postnatal development soft tissue therapeutic development three-dimensional modeling vibration vocal cord vocalization wound healing

项目摘要

Project Summary The development and maintenance of a speaking and singing fundamental frequency, while also achieving vocal clarity throughout life, are important public health concerns. Symptoms of dysphonia are among the most common communication disorders. Currently there is no treatment to restore a native vocal fold lamina propria composition or laryngeal movements after injury. Research is limited because there is no in vivo model for larynx injuries that express a vocal behavior that can serve as a reliable phenotypic marker. In general, an animal model can benefit research if its behavior can serve as marker for the onset or the time-course of a pathology affecting a complex behavior. Specifically, the availability of an animal model that combines experimental and genetic accessibility with important similarities to human voice production could allow stronger inferences. Here we propose (1) to quantify key anatomical features of the vocal organ during postnatal developmental in a new model, and (2) to describe the time-course of wound healing after experimental vocal fold injury in a vocal dose- dependent fashion. Results will be integrated in a computational vocal fold model. Completion of this work will provide the field with a new mouse model for the study of vocal disease mechanisms and therapeutic development. It will also inform the role of vocal occupancy on the healing process of vocal folds.

项目摘要讲话和唱歌的基本频率的发展和维护，同时也实现了声音清晰度一生都是重要的公共卫生问题。吞咽困难的症状是最常见的交流之一疾病。目前尚无治疗方法来恢复本地声带椎板固有组成或喉运动受伤后。研究受到限制，因为没有喉损伤的体内模型表达发声行为可以用作可靠的表型标记。通常，如果动物模型的行为可以作为标记，则可以使研究受益对于影响复杂行为的病理的发作或时间顺序。具体而言，动物的可用性结合实验和遗传可及性与与人音生产重要相似之处的模型可以允许更强的推论。在这里，我们建议（1）量化产后声音器官的关键解剖特征在新模型中的发展，（2）描述实验性声折损伤后伤口愈合的时间顺序依赖于声音剂量的方式。结果将集成到计算声折模型中。完成这项工作将为该领域提供一种新的小鼠模型，以研究人声疾病机制和治疗性发育。它还将告知声乐占用率在人声褶皱的康复过程中的作用。