High Framerate Plane-Wave Variance of Acceleration and Vector Flow Imaging for the Characterization of Atherosclerotic Plaque Morphology and Assessment of Vascular Hemodynamics

高帧率平面波加速度方差和矢量流成像用于动脉粥样硬化斑块形态的表征和血管血流动力学的评估

• 批准号: 10461534
• 负责人: Keerthi Surej Anand
• 金额: $ 3.92万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10461534
• 关键词: 3-Dimensional; Acceleration; Acoustics; Arterial Fatty Streak; Biopsy; Blood Vessels; Blood flow; Calcium; Cardiac; Cardiovascular Diagnostic Techniques; Cardiovascular Diseases; Carotid Arteries; Carotid Endarterectomy; Cause of Death; Characteristics; Clinical; Code; Collagen; Computer Models; Data; Data Collection; Detection; Development; Diagnostic; Diagnostic Imaging; Disease Progression; Doppler Ultrasound; Environment; Future; Geometry; Goals; Gold; Growth; Heating; Hemorrhage; Histologic; Human; Image; Imaging Device; Ionizing radiation; Ischemic Stroke; Lipids; Liquid substance; Location; Measurement; Measures; Mechanics; Methods; Modeling; Monitor; Morphologic artifacts; Morphology; Motion; Names; Necrosis; Noise; Operative Surgical Procedures; Outcome; Patients; Pattern; Phenotype; Physicians; Physics; Physiologic pulse; Physiological; Play; Procedures; Property; Public Health; Radiation; Resolution; Risk; Risk Assessment; Rupture; Scheme; Sensitivity and Specificity; Signal Transduction; Solid; Stenosis; Stress; Stroke prevention; Structure; Techniques; Technology; Time; Tissue imaging; Tissues; Translating; Ultrasonography; Validation; Work; atherosclerotic plaque rupture; base; clinical decision-making; combat; cost; design; diagnosis standard; early screening; elastography; feature detection; hemodynamics; holistic approach; image processing; imaging approach; improved; in vivo; logarithm; mechanical properties; meetings; minimally invasive; novel; operation; preclinical study; risk prediction; screening; shear stress; signal processing; simulation; spatiotemporal; stroke risk; tool; ultrasound; vector

PROJECT SUMMARY The need for minimally invasive methods for screening early predictors of ischemic stroke are required to combat the increase in cardiovascular disease cases while reducing number of unnecessary carotid endarterectomies, which are invasive but preventative procedures to remove plaques. The current gold-standard for diagnosis, duplex ultrasound, is often used to detect heavily occluded vasculature, but simply noting the degree of stenosis is an insufficient measure of plaque rupture vulnerability. Acoustic Radiation Force Impulse (ARFI) ultrasound technique recently emerged as a potential method to separate vulnerable from stable plaques through delineation of plaque components. However, as the technique relies on emission of high intensity focused acoustic pulses, although nondestructive, the potential for tissue heating limits extended uses, while the long period of data collection increases opportunities for motion artifacts to corrupt data collection and physiological interpretation of results. The use of a new ultrafast ARFI imaging sequence to evaluate both plaque structure and surrounding hemodynamics may provide significant advancement in reducing acquisition time, reducing acoustic heating, and improving risk prediction. There exists overwhelming evidence that mechanics of plaque growth and rupture are governed by shear forces acting on the vessel walls. Monitoring the dynamics changes in shear stress in addition to more efficiently detecting plaque composition may prove a novel avenue for discerning at risk patients with vulnerable atherosclerotic plaques vs those with stable plaque phenotypes. We propose to further develop and characterize ultrasound parallel transmit sequences to image tissue in rapid succession and additionally detect multi directional blood flow around the vasculature. Combining the ARFI elastography, high framerate imaging, and flow information allows a real-time realizable assessment of the plaque environment throughout the entire cardiac cycle. Therefore, meeting the aims of the study will further develop diagnostic imaging tools for future stroke risk assessment.

项目摘要 需要最少侵入性的方法来筛选缺血性中风的早期预测指标 打击心血管疾病病例的增加，同时减少不必要的颈动脉数量 内部切除术，是侵入性但预防性的牙菌斑的程序。当前的金标准 为了诊断，双链超声通常用于检测严重遮挡的脉管系统，而只是注意到 狭窄程度是对斑块破裂脆弱性的不足。声辐射冲动 （ARFI）最近出现的超声技术是一种潜在的方法，可以将易受伤害与稳定斑块分开 通过描绘牌匾成分。但是，由于该技术依赖于高强度的排放 聚焦的声脉冲，尽管无损，但组织加热极限的潜力扩展使用，而 长时间的数据收集增加了运动工件的机会，以损坏数据收集和 结果的生理解释。使用新的超快ARFI成像序列来评估这两者 牙菌斑结构和周围的血液动力学可能会在减少方面显着进步 获取时间，减少声学加热并改善风险预测。存在压倒性的 证据表明，菌斑生长和破裂的力学受到作用在容器壁上的剪切力。 除了更有效地检测斑块组成外，还监测剪切应力的动力学变化 可能证明是一种新颖的途径，可以辨别在风险患者的风险患者中 稳定的斑块表型。我们建议进一步发展和表征超声平行的传输 快速连续图像组织的序列，并进一步检测到周围的多方向血流 脉管系统。结合ARFI弹性图，高帧率成像和流量信息允许实时 在整个心脏周期中，可以对牙菌斑环境进行可实现的评估。因此，见面 该研究的目的将进一步开发诊断成像工具，以进行未来的中风风险评估。