Clinical Translational Core

临床转化核心

• 批准号: 10673844
• 负责人: Aysenil Belger
• 金额: $ 43.65万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-28 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673844
• 关键词: 17 year old; Age; Behavior; Behavioral; Behavioral Mechanisms; Brain; Brain imaging; Center for Translational Science Activities; Characteristics; Child; Child Development; Clinic; Clinical; Clinical Research; Cognitive; Collaborations; Complex; Computerized Medical Record; Consent; Consultations; Custom; Data; Data Science Core; Development; Diagnostic; Diffusion Magnetic Resonance Imaging; Disease; Electroencephalography; Exposure to; Family; Feedback; Fragile X Syndrome; Functional Magnetic Resonance Imaging; Genetic study; Goals; Grant; Human; Image; Image Analysis; Imaging Device; Individual; Infant; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Interdisciplinary Study; Intervention; Laboratories; Magnetic Resonance Imaging; Maps; Measurement; Methodology; Methods; Molecular Genetics; Neurodevelopmental Disorder; Neurosciences; North Carolina; Outcome; Participant; Pathogenesis; Patient Recruitments; Patients; Phenotype; Play; Population; Preparation; Protocols documentation; Quality of life; Recording of previous events; Registries; Research; Research Design; Research Personnel; Research Support; Resources; Risk Marker; Sampling; Services; Structure; Training; Translational Research; Universities; autism spectrum disorder; behavior measurement; clinical development; clinical translation; clinically relevant; design; electronic data; guided inquiry; improved; innovation; multimodality; neuroimaging; novel; pre-clinical; preclinical study; psychosocial; recruit; targeted treatment; tool; visual tracking

Abstract The Clinical Translational Core (CTC) of the University of North Carolina Intellectual and Developmental Disabilities Research Center (IDDRC) is a highly successful core that catalyzes key resources to provide two classes of services: (1) the Participant Registries (PR) serve to maximize recruitment of research participants in IDDRC research; and (2) the Brain & Behavior Measurement Laboratory (BBML) assists UNC IDDRC investigators with multi-modal characterization of brain structure and function and behavior to advance the discovery of early risk markers, brain and behavior mechanisms, targets for therapeutics, and outcome metrics for assessing the impact of interventions. In this application, 39 projects from 27 IDDRC investigators are proposed for core access. The BBML further assists investigators with the design, measurement, and analysis of clinical neuroscience studies, and provides assistance with the development of clinical teams. The structure of the PR and BBML promotes cross-disciplinary interactions critical to maximizing the potential to understand the pathogenesis and treatment of IDDs. The Specific Aims of the CTC are: (1) to maximize recruitment of research participants for clinical studies; (2) to develop and provide access to tools and services that maximize the ability of IDDRC investigators to conduct cutting-edge clinical studies of brain and behavior measurement in IDD research; and (3) to facilitate translational IDD research by facilitating linkages between human and preclinical studies and the promotion of interdisciplinary research. The overarching objective of the CTC is to support clinical translational research that advances our understanding of the pathogenesis and treatment of IDDs. The core catalyzes translational IDD research at UNC by providing key support and services, ranging from consultation on the initiation of interdisciplinary projects, to supporting the formation of interdisciplinary teams, assisting in the design of complex experimental protocols, providing access to a large well- characterized pool of participants, to desiging custom-built and project-specific innovative neuroimage analysis tools. By providing access to resources and expertise in IDD research, the CTC integrates cutting-edge cognitive, behavioral, and clinical neuroscience methods to capitalize on our strengths in imaging and, in particular, early brain development. This integration of recruitment, phenotyping, study design, and brain imaging tools and resources in this CTC has catalyzed translational IDD research at UNC. Indeed, the development of novel image analysis tools customized for infant brains, early in the history of this core, has transformed the field’s understanding of infant brain development. The tools developed by this core have played key roles in translational research examining early risk markers of, brain markers of exposure to bio- psycho-social adversity, and characterizing the impact of interventions. 1

抽象的 北卡罗来纳大学知识与发展大学的临床翻译核心（CTC） 残疾研究中心（IDDRC）是一个非常成功的核心，可促进关键资源提供两个 服务类别：（1）参与者注册机构（PR）有助于最大化研究参与者的招聘 在IDDRC研究中； （2）大脑和行为测量实验室（BBML）有助于UNC IDDRC 对大脑结构，功能和行为的多模式表征的研究者，以促进 发现早期风险标记，大脑和行为机制，治疗目标以及结果指标 用于评估干预措施的影响。在此应用程序中，来自27个IDDRC调查人员的39个项目是 提议用于核心访问。 BBML进一步协助研究人员进行设计，测量和分析 临床神经科学研究，并为临床团队的发展提供帮助。结构 PR和BBML的促进跨学科互动至关重要 IDD的发病机理和治疗。 CTC的具体目的是：（1）最大化 临床研究的研究参与者； （2）开发并提供最大化工具和服务的访问 IDDRC研究人员进行大脑和行为测量的尖端临床研究的能力 在IDD研究中； （3）通过促进人与人之间的联系来促进转化IDD研究 临床前研究和促进跨学科研究。 CTC的总体目标是 支持我们对我们对发病机理和治疗的理解的临床翻译研究 IDD。核心通过提供关键支持和服务来促进UNC的转化IDD研究 从跨学科项目的倡议咨询到支持跨学科的形成 团队，协助设计复杂的实验协议，为大型井提供访问 参与者的特征池，以定制和特定项目的创新神经图像分析 工具。通过提供IDD研究中的资源和专业知识的访问，CTC整合了尖端 认知，行为和临床神经科学方法，以利用我们在成像方面的优势，并在 特别是早期大脑发育。招聘，表型，研究设计和大脑的整合 该CTC中的成像工具和资源催化了UNC的转化IDD研究。确实， 在此核心历史的早期，针对婴儿大脑定制的新型图像分析工具的开发已有 改变了该领域对婴儿大脑发育的理解。该核心开发的工具具有 在转化研究中发挥了关键作用，检查了早期风险标志物，暴露于生物的大脑标志物 心理社会逆境，并表征干预措施的影响。 1