Ecological Assessment of Cognitive Control in Individuals with Social Anxiety

社交焦虑个体认知控制的生态评估

• 批准号: 10740262
• 负责人: George Arthur Buzzell
• 金额: $ 40.56万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10740262
• 关键词: 17 year old; Adolescence; Adolescent; Affect; Age; Anxiety; Behavior; Behavioral; Brain; Characteristics; Childhood; Computers; Data; Data Collection; Detection; Disease; Electroencephalography; Emotions; Exhibits; Future; Goals; Hypersensitivity; Impairment; Individual; Intervention; Interview; Investigational Therapies; K-12 Education; Laboratories; Letters; Link; Measures; Mental disorders; Methods; Mission; Modeling; Monitor; Natural Extract; Participant; Perception; Pilot Projects; Population; Probability; Process; Protocols documentation; Qualitative Methods; Quality of life; Reading; Response to stimulus physiology; Role; Sampling; Self Assessment; Series; Social Anxiety Disorder; Speed; Stimulus; Stress; Structure; System; Task Performances; Therapeutic; Transcript; Validation; Work; Youth; anxiety states; behavior measurement; behavioral response; brain based; cognitive control; cognitive neuroscience; demographics; design; high risk; neural; neuromechanism; novel; peer; response; social; social anxiety; social observations; standardize measure; success; therapeutic target; trait

PROJECT SUMMARY Social anxiety disorder is an impairing condition that typically emerges during adolescence, affecting about 10% of the population. Models of social anxiety (SA) elucidate excessive self-focus and sensitivity to mistakes as factors that negatively impact quality of life. Using traditional cognitive neuroscience paradigms, prior work has identified neural measures associated with enhanced self-detection of errors (Error Monitoring), that predicts SA, as well as anxiety more generally. However, a major challenge with translational interventions developed from cognitive neuroscience paradigms is the transfer to ecologically valid settings. There is a critical need for the design and validation of novel tasks/protocols to identify and reliably measure brain-based therapeutic targets for SA within ecologically valid, “real-world” settings that are applicable to youth. In line with our long-term goal of developing brain-based interventions for adolescent SA, the purpose of this proposal is to optimize and validate a novel, ecologically-valid task that will reliably assess neural and behavioral measures associated with social anxiety. We propose a sequential, multi-study project that leverages a mixed-methods approach to optimize and validate our novel Natural Reading task and demonstrate its utility in predicting SA. By developing an ecologically-valid paradigm early in the experimental therapeutics process, we increase the probability of successful transfer of effects in future interventions that target measures captured by this novel task; in this way, our proposal is strongly aligned with the Institute’s mission to transform the understanding and treatment of mental illnesses. We propose two aims: (1) a pilot study to optimize the design of our novel Natural Reading task and (2) a second study to establish the reliability and predictive power of the Natural Reading task in relation to SA. In Study 1, 10 youths (13-17 yrs., 5 high and 5 low SA) will perform the Natural Reading task and a traditional Flanker task, both alone and while under social observation by a peer. To investigate experiential aspects of task completion, including participants' perceptions and self-assessed task performance, qualitative methods will be employed in the analysis of semi-structured interview data. Qualitative results will be leveraged to optimize design of the Natural Reading task prior to proceeding with Study 2 data collection (Aim 2). For Study 2, within a second sample of 80 youth (13-17 yrs.), participants will perform an optimized version of the Natural Reading task and a traditional Flanker task, alone and under peer observation. Neural measures of Error Monitoring, along with associated behavioral measures, will be extracted to perform quantitative analyses. Hypothesis 2A: Both tasks will exhibit acceptable levels of reliability in neural and behavioral measures. Hypothesis 2B: Within each task, measures of Error Monitoring extracted from the peer (vs. alone) condition will predict additional variance in trait SA and state anxiety levels. Hypothesis 2C: Focusing on the peer condition, measures of Error Monitoring extracted from the Natural Reading Task will predict additional variance in SA, above and beyond measures of Error Monitoring extracted from the traditional Flanker task.

项目摘要 社交焦虑症是一种通常在青少年期间出现的损害状况，影响约10％ 人口。社交动画模型（SA）阐明过多的自我聚焦和对错误的敏感性 对生活质量产生负面影响的因素。使用传统的认知神经科学范例，先前的工作 确定了与增加错误的自我检测相关的神经元测量（错误监测），以预测SA， 以及更普遍的焦虑。但是，转化干预措施的重大挑战 认知神经科学范式是转移到生态有效的环境中。迫切需要 设计和验证新的任务/协议，以识别且可靠的测量基于大脑的治疗目标 对于适用于年轻人的生态有效的“现实世界”环境中的SA。符合我们的长期目标 为青少年SA开发基于大脑的干预措施，该建议的目的是优化和 验证一项新颖的生态涉及任务，该任务将可靠地评估与 社交动画。我们提出了一个顺序的多阶级项目，该项目利用了混合方法的方法 优化和验证我们新颖的自然阅读任务，并证明其在预测SA方面的实用性。通过发展 在实验疗法过程的早期，生态涉及范式范式，我们增加了 在未来的干预措施中成功转移效果，这些干预措施针对这项新任务捕获的措施；这样， 我们的提议与研究所的使命密切相符，旨在改变对 精神疾病。我们提出了两个目标：（1）一项试点研究，以优化我们新颖的自然阅读任务的设计 （2）第二项研究，以建立自然阅读任务的可靠性和预测能力 SA。在研究1中，有10名年轻人（13-17岁，5个高和5低SA）将执行自然阅读任务和传统 侧翼任务，无论是一个人还是在同伴的社会观察下。调查专家方面 任务完成，包括参与者的看法和自我评估的任务绩效，定性方法将 在半结构化访谈数据的分析中进行。定性结果将被利用以优化 在进行研究2数据收集之前，自然阅读任务的设计（AIM 2）。在研究2中 第二个样本为80名青年（13 - 17年），参与者将执行自然阅读的优化版本 任务和传统的侧翼任务，单独和同行观察。错误监测的神经度量， 除了相关的行为度量外，还将提取进行定量分析。假设2a： 这两个任务将在神经和行为措施中表现出可接受的可靠性水平。假设2b：内部 每个任务，从同伴（与单独）条件提取的错误监视的度量衡量标准将预测其他 特质SA和状态焦虑水平的差异。假设2C：专注于同伴条件，误差措施 从自然阅读任务中提取的监视将预测SA的额外差异， 从传统侧翼任务中提取的错误监视的度量。