A new reference atlas of brain networks to investigate neuropsychiatric traits in adolescents

用于研究青少年神经精神特征的新大脑网络参考图集

• 批准号: 10585096
• 负责人: Gaelle Eve Doucet
• 金额: $ 8.1万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-26 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10585096
• 关键词: 17 year old; Adolescence; Adolescent; Adolescent Development; Adult; Age; Architecture; Atlases; Brain; Brain Mapping; Childhood; Cognitive; Communities; Data; Data Set; Development; Event; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Genetic; Hospitals; Human; Image; Incidence; Individual; Link; Literature; Longevity; Maps; Measures; Mental Health; Mental disorders; Mind; National Institute of Mental Health; Neurocognition; Outcome; Participant; Phase; Phase Transition; Philadelphia; Psychopathology; Puberty; Public Health; Reproducibility; Research; Rest; Risk; Sampling; Sex Differences; Site; Testing; Validity and Reliability; Work; Youth; age group; age related; aged; boys; cognitive ability; cohort; connectome; critical developmental period; critical period; early adolescence; girls; improved; lens; network architecture; network dysfunction; neural; neuroimaging; neuropsychiatry; sex; trait

PROJECT SUMMARY Adolescence is typically defined as the transition period between childhood and adulthood. It is a critical period for neural changes, including maturation of the brain’s cognitive networks, but also a period of increased vulnerability to psychopathology. It is well accepted that the brain is functionally organized into multiple interacting networks and extensive literature has demonstrated that the spatial and functional organization of these networks shows major age-related changes across the lifespan, but particularly during adolescence. Yet, there is currently no reference functional brain atlas derived from typically-developing adolescents, which is especially problematic as the reliable and reproducible identification of functional brain networks crucially depends on the use of such reference functional atlases. Furthermore, the use of atlases derived from adults may undermine the validity and reliability of developmental neuroimaging research. Using preliminary data for this application and previous works, we show that an age-appropriate functional brain atlas will improve the characterization of the brain functional connectome and its links to neuropsychiatric traits in youth. In this context, the aim of this application is to construct and validate the first reference functional brain atlas in typically-developing youth between the age of 8 and 17 years. To achieve this, we will use resting-state functional MRI (rs-fMRI) from the three largest developmental neuroimaging datasets. Our first aim (Aim 1) is to generate a reference atlas, called “Dev-Atlas”, using the rs-fMRI datasets from approximately 2,000 youths. We will then (Aim 2) demonstrate the replicability of Dev-Atlas in two independent large samples of typically- developing youth (Dev-Cog: n=230; Dev-MIND: n=310), collected at Boys Town National Research Hospital and the Mind Research Network. Because girls, on average, enter puberty one to two years earlier than boys, we will test (Aim 3) whether girls show brain network differences compared to boys. In the event of significant sex differences, we will create the first sex-specific functional brain atlases for youth. Finally, we will demonstrate the superiority of network connectivity features derived from Dev-Atlas compared to atlases based on data from adults in predicting a greater amount of the variance in psychiatric traits (Aim 4). The successful completion of this project will provide the first reliable functional brain atlas for youth aged 8-17 years old, which will be made freely available to the research community. By mapping the brain functional connectome underlying childhood and adolescence, this work has the potential to elucidate how brain network dysfunction contributes to psychiatric traits and the risk for mental health disorders in adolescence.

项目摘要 青少年通常定义为儿童和成年之间的过渡期。这是一个关键时期 用于神经元的变化，包括大脑认知网络的成熟，但也增加了 精神病理学的脆弱性。很公认的是，大脑在功能上组织了多个 互动网络和广泛的文献表明，空间和功能组织 这些网络显示了整个生命周期的主要变化，尤其是在青少年期间。然而， 当前没有典型开发的青少年的参考功能大脑图集，这是 尤其是有问题的，作为功能大脑网络的可靠且可重复的识别 取决于使用此类参考功能地图集。此外，使用源自成年人的地图集 可能会破坏发育神经影像研究的有效性和可靠性。使用初步数据 这项应用程序和以前的工作，我们表明，适合年龄的功能性大脑图集将改善 大脑功能连接组的表征及其与青年中神经精神特征的联系。在这个 上下文，此应用的目的是构建和验证第一个参考功能大脑图集 通常在8至17岁之间开发的年轻人。为了实现这一目标，我们将使用静止状态 来自开发神经影像数据集的三个最大的功能性MRI（RS-FMRI）。我们的第一个目标（目标1）是 使用来自大约2,000名青年的RS-FMRI数据集生成一个称为“ Dev-Atlas”的参考图集。 然后，我们将（AIM 2）证明Dev-Atlas在两个独立的大型样本中的可复制性 - 发展年轻人（Dev-cog：n = 230; dev-mind：n = 310），在男孩镇国家研究医院收集 和思维研究网络。因为女孩平均比男孩早1-两年进入青春期，所以 我们将测试（AIM 3）女孩是否表现出与男孩相比显示脑网络差异。如果有重大 性别差异，我们将为青年创建第一个特定性别的功能性脑图。最后，我们会的 证明与地图集相比 基于成年人的数据预测精神病特征的差异更多（AIM 4）。这 该项目的成功完成将为8-17岁的青年提供第一个可靠的功能性大脑图集 多年历史，将为研究社区免费提供。通过映射大脑功能 Connectome的童年和青少年，这项工作有可能阐明大脑网络 功能障碍会导致精神病特征和青少年心理健康障碍的风险。