Adult Changes in Thought (ACT) Research Program Core C: Life Course Core

成人思想转变 (ACT) 研究计划核心 C：生命历程核心

• 批准号: 10672349
• 负责人: Sarah Elizabeth Tom
• 金额: $ 106.58万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10672349
• 关键词: Adherence; Adult; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Antihypertensive Agents; Area; Autopsy; Birth; Blood Pressure; Brain; Censuses; Clinical; Cognition; Cognitive; Collection; Communities; Data; Data Aggregation; Data Collection; Data Files; Data Sources; Dementia; Development; Disparate; Economics; Elderly; Electronics; Employment; Enrollment; Future; Geography; Goals; Government; Growth; Head circumference; Health; Health Policy; Healthcare; Hypertension; Impaired cognition; Individual; Influentials; Injury; Integrated Delivery of Health Care; Intervention; Investigation; Leadership; Life; Life Cycle Stages; Life course epidemiology; Longitudinal cohort; Measures; Mediating; Medical Records; Modernization; Neurologic; Neurosciences; Occupations; Outcome; Paper; Participant; Pattern; Pharmaceutical Preparations; Physical activity; Prevention; Public Domains; Questionnaires; Recording of previous events; Records; Research; Research Personnel; Resources; Risk; Role; Science; Scientific Inquiry; Social Environment; Social Network; Socioeconomic Status; Source; Subgroup; Surveys; System; Testing; Time; United States; Variant; Washington; Work; adverse childhood events; aging brain; blood pressure reduction; built environment; caregiving; cerebrovascular; clinical care; cognitive function; cohort; college; data sharing; dementia risk; econometrics; electronic data; ethnic diversity; experience; health care delivery; health data; improved; innovation; middle age; programs; racial diversity; social; social determinants; socioeconomics

CORE C: LIFE COURSE CORE PROJECT SUMMARY The Adult Changes in Thought (ACT) U19 Research Program’s overarching goal is to use a life course approach to investigate modifiable and other factors that influence cognition and Alzheimer’s disease and related dementia, including better understanding of underlying mechanisms. The Life Course Core provides data and theoretical support for this goal. The Core leverages existing Kaiser Permanente Washington (KPWA) electronic data files and medical records, existing ACT data, new survey instruments, and data in the public domain. By efficiently building on the extensive resources of ACT as a long-standing longitudinal cohort set in a health care delivery system, the Life Course Core will support scientific inquiry to enhance our understanding of aging, especially brain aging and dementia and Alzheimer’s disease. The interdisciplinary Core team with expertise in life course epidemiology, the built environment, neuroscience, and health policy and econometrics will support the life course framework in all Projects and Core activities. The Life Course Core’s Specific Aims are: Aim 1) To aggregate data from disparate sources (including administration of a questionnaire and linkage to external data sources) to characterize socioeconomic status over the life course; Aim 2) To test the hypothesis that specific crucial times in brain development and function determine the timing of the relevance of individual and area level socioeconomic status indicators to cognitive trajectories in late life; and Aim 3) To assist the Projects in identifying relevant life course parameters from newly collected and existing variables and partner with Cores to integrate the most influential variables into their analyses to understand the spectrum of robust cognitive function to dementia. Integrating new social and health data over the life course will allow this Core to work with other cores to support aims across the three Projects and broader scientific endeavors. We will work particularly closely with the Clinical Core and the Data and Analysis Core to collect and share data, respectively. The Life Course Core serves a central role in the U19 by providing thematic unification that will transform the future value of ACT U19 Program science.

核心C：生命课程核心 项目摘要 成人思想变化（ACT）U19研究计划的总体目标是使用生活课程 调查影响认知和阿尔茨海默氏病的其他因素和其他因素的方法 相关的痴呆症，包括更好地了解基本机制。生命课程核心提供 对此目标的数据和理论支持。核心利用现有的Kaiser Permanente华盛顿 （KPWA）电子数据文件和医疗记录，现有ACT数据，新调查工具以及数据中的数据 公共领域。通过有效建立作为长期纵向队列的广泛资源 生活课程核心将在医疗保健提供系统中，将支持科学探究以增强我们的 了解衰老，尤其是大脑衰老和痴呆症和阿尔茨海默氏病。跨学科 具有人生课程专业知识流行病学，建筑环境，神经科学和健康政策的核心团队 经济学将支持所有项目和核心活动的生活课程框架。生活过程 核心的具体目的是：目标1）从不同来源汇总数据（包括管理 问卷和与外部数据源的联系）以表征生活过程中社会经济地位； 目标2）测试以下假设：大脑发育和功能中的特定关键时期确定时间安排 个人和地区层面的社会经济地位指标与后期认知轨迹的相关性； 目标3）协助项目确定新收集的相关生活课程参数，并 现有变量和与核心的合作伙伴将最具影响力的变量整合到其分析中 了解痴呆症的强大认知功能的频谱。将新的社会和健康数据整合在一起 生活课程将使该核心与其他核心合作，以支持三个项目的目标， 更广泛的科学努力。我们将与临床核心和数据特别紧密合作， 分析核心分别收集和共享数据。生命课程核心在U19中起着核心作用 通过提供主题统一，将改变U19计划科学的未来价值。