Real-time spectroscopic photoacoustic/ultrasound (PAUS) scanner withsimultaneous fluence and motion compensation to guide and validateinterventions: system development and preclinical testing.

实时光谱光声/超声 (PAUS) 扫描仪，具有同步注量和运动补偿功能，可指导和验证干预措施：系统开发和临床前测试。

基本信息

批准号：
10672299
负责人：
Matthew O'Donnell
金额：
$ 73.27万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-22 至 2025-06-30
项目状态：
未结题

项目摘要

Abstract The goal of this project is to develop a clinical real-time spectroscopic photoacoustic/ultrasound (PAUS) system for molecular guidance of interventional procedures through a partnership between UW and GE Research. Recently, we proposed a new, fast-sweep concept for PA imaging. To put this concept into practice, we first developed a unique, compact, diode-pumped, tunable (700 -900 nm) laser operating at very high (up to 1000 Hz) repetition rates and relatively low (~ 1 mJ) pulse energies, and a fiber-optic delivery system to sequentially couple laser pulses into the imaging probe. In addition to US B-mode, and all other US modes, the system simultaneously produces real-time (50 Hz) spectroscopic PA images, which were combined for the first time for real-time PAUS imaging. A unique feature is automatic on-line laser-fluence compensation and motion correction, enabling quantitative optical absorption spectroscopy at every image pixel. Spectroscopy can identify substances opaque to US based on their molecular constituents (drugs/contrast agents), and quantify tissue functional changes (e.g., blood oxygenation and its concentration) within the image; in addition, manipulation with a needle is better visualized with PA. UW will work with GE Research to integrate spectroscopic PAUS into a high-end US scanner to create a clinical-grade PAUS system, and test whether it can improve interventional procedure guidance in general and, particularly, in ethanol (EA) ablation therapies of recurrent thyroid tumors. The prognosis for most people with thyroid cancer after primary treatment is very good, but the recurrence rate or persistence can be up to 30%. If recurrent cancer is confirmed, image-guided nonsurgical procedures such as EA or radio frequency ablation (RFA) are commonly used alternatives to more invasive procedures. Although US helps position EA and RFA needles, on-line imaging of the ablative area and confirmation of ablation remain difficult for US. When the recurrent nodule (especially the capillary network in it) is not entirely treated, the cancer will return with possible metastasis. We hypothesize here that real-time spectroscopic PAUS will improve the efficacy of ablation procedures and dramatically reduce procedure repetitions. If successful in this initial stage, the project will move to a clinical trial to both guide and validate ablative therapies and explore real-time spectroscopic PAUS for other interventional procedures. SA1 will integrate our unique laser and scanning fiber-optic delivery system with a clinical GE US scanner for real-time spectroscopic PAUS. Then, SA2 will develop real-time signal processing tools for motion correction and fluence compensation and imaging protocols for spectroscopic PAUS. SA3 will focus on optimizing the PAUS system using phantom and ex vivo studies. Finally, in SA4 the developed PAUS system will be used to test the clinical applicability of PAUS guidance with three in vivo models, including small animal studies of thyroid cancer, an animal model approximating human anatomy, and pilot measurements on human subjects.

抽象的该项目的目标是开发临床实时光谱光声/超声（PAUS）系统通过华盛顿大学和通用电气研究中心之间的合作，对介入手术进行分子指导。最近，我们提出了一种新的 PA 成像快速扫描概念。为了将这一理念付诸实践，我们首先开发了一种独特、紧凑、二极管泵浦、可调谐 (700 -900 nm) 激光器，工作温度非常高（高达 1000 Hz）重复率和相对较低（~ 1 mJ）的脉冲能量，以及光纤传输系统将激光脉冲耦合到成像探头中。除了 US B 模式和所有其他 US 模式外，系统同时生成实时 (50 Hz) 光谱 PA 图像，这些图像首次合并用于实时 PAUS 成像。一个独特的功能是自动在线激光注量补偿和运动校正，实现每个图像像素的定量光学吸收光谱。光谱分析可以根据其分子成分（药物/造影剂）识别对美国不透明的物质，并量化图像内的组织功能变化（例如，血液氧合及其浓度）；此外，使用 PA 可以更好地显示用针进行的操作。华盛顿大学将与 GE Research 合作，将光谱 PAUS 集成到高端美国扫描仪中，以创建临床级 PAUS 系统，并测试它是否可以总体上改善介入手术指导，特别是在复发性甲状腺肿瘤的乙醇（EA）消融治疗中。大多数甲状腺癌患者经过初步治疗后预后非常好，但复发率较高或持久性可达30%。如果确诊癌症复发，可以进行影像引导的非手术治疗，例如因为 EA 或射频消融 (RFA) 是更具侵入性手术的常用替代方案。尽管美国帮助定位 EA 和 RFA 针，但消融区域的在线成像和确认美国的消融仍然很困难。当复发结节（尤其是其中的毛细血管网络）未完全消失时经过治疗后，癌症会复发并可能发生转移。我们在这里假设实时光谱 PAUS 将提高消融手术的效率并显着减少手术重复次数。如果该项目在初始阶段取得成功，将进入临床试验以指导和验证消融疗法并探索实时光谱 PAUS 用于其他介入手术。 SA1 将我们独特的激光和扫描光纤传输系统与临床 GE US 扫描仪集成在一起，用于实时光谱 PAUS。然后，SA2将开发用于运动校正的实时信号处理工具以及光谱 PAUS 的注量补偿和成像方案。 SA3将重点优化 PAUS 系统使用模型和离体研究。最后，在SA4中，开发的PAUS系统将用于使用三种体内模型测试 PAUS 指导的临床适用性，包括小动物研究甲状腺癌、接近人体解剖学的动物模型以及对人类受试者的初步测量。