CATHETER ARRAY FOR MECHANICAL IMAGING OF CORONARY ARTERY

用于冠状动脉机械成像的导管阵列

• 批准号: 2332496
• 负责人: Matthew O'Donnell
• 金额: $ 27.08万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-02-01 至 2000-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2332496
• 关键词: angiocardioultrasonography; atherosclerosis; biomechanics; biomedical equipment development; cardiovascular imaging /visualization; computer simulation; coronary artery; diagnosis design /evaluation; diagnostic catheterization; disease /disorder model; elasticity; histopathology; human tissue; intraluminal angioplasty; laboratory rabbit; postmortem; prognosis; restenosis; swine; ultrasonography

Great progress has been made in the last 5 years in intravascular imaging of coronary arteries. It is the fundamental premise of this proposal, however, that current intravascular imaging devices can be dramatically improved and extended to provide more than diagnostic information alone. In particular, images of tissue hardness (i.e., elasticity) may provide critical feedback to both guide therapy and predict the likelihood of eventual restenosis. In effect, such elasticity images may allow the clinician to "feel" the arterial wall while performing catheter based procedures. To generate mechanical images of coronary arteries, an ultrasound imaging system must be integrated into a controlled mechanical deformation device resident in the lumen of the vessel. The ultrasound imager proposed for this device is a catheter based array system that can dynamically focus an ultrasound beam over a large depth of field using only a single connection between the catheter tip and the imaging console. Although simple in construction, it has the potential to produce high resolution images of coronary vessels. The array transducer is placed within a conventional balloon angioplasty catheter, where the balloon intersects the imaging plane. By slowing and continuously deforming the arterial wall with the balloon while simultaneously imaging with the catheter array, data can be acquired to image the elastic properties of the wall. Since elasticity correlates well with the human sense of touch, mechanical images may allow the clinician to "palpate" coronary vessels during diagnostic and therapeutic procedures. As part of the proposed research plan, all technical issues related to this system, including motion artifacts, specific image reconstruction algorithms, deformation measurements and custom probes, will be addressed. It is one of the primary objectives of this proposal to construct a prototype system demonstrating the capabilities of mechanical imaging of coronary arteries.

在过去的5年中，在血管内成像中取得了巨大进展 冠状动脉。 这是该提议的基本前提， 但是，当前的血管内成像设备可以显着 改进和扩展以提供不仅提供诊断信息。 特别是，可以提供组织硬度的图像（即弹性） 指导治疗的重要反馈和预测 最终再狭窄。 实际上，这种弹性图像可能允许 临床医生在执行基于导管的同时“感觉到”动脉壁 程序。 为了生成冠状动脉的机械图像，超声成像 系统必须集成到受控的机械变形设备中 居民在船只的管腔中。 提出的超声图像仪 该设备是基于导管的阵列系统，可以动态聚焦 超声梁仅使用单个连接在大景深上 在导管尖端和成像控制台之间。 虽然很简单 结构，它有可能产生高分辨率的图像 冠状动脉。 阵列传感器放置在传统的 气球血管成形术导管，气球与成像相交 飞机。 通过放慢并连续畸形的动脉壁 气球在与导管阵列同时成像时，数据可以是 获得以成像壁的弹性特性。 自弹性以来 与人类的触觉相关，机械图像可能允许 诊断期间，临床医生要“触诊”冠状动脉 治疗程序。 作为拟议的研究计划的一部分，与 该系统，包括运动伪影，特定图像重建 将解决算法，变形测量和自定义探针。 它是本提案的主要目标之一 原型系统展示了机械成像的功能 冠状动脉。