Optoacoustic Transduction for High-Frequency Ultrasound

高频超声的光声转换

• 批准号: 6976723
• 负责人: Matthew O'Donnell
• 金额: $ 33.01万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6976723
• 关键词: bioimaging /biomedical imaging; cardiovascular imaging /visualization; catheterization; coronary artery; fiber optics; fluoroscopy; polymers; sound frequency; technology /technique development; three dimensional imaging /topography

DESCRIPTION (provided by applicant): Over the last several years we have developed a technology to optically generate ultrasound using laser pulses absorbed in thin polymer films. This approach produces ultrasonic intensity comparable to piezoelectric counterparts and is especially attractive for high-frequency applications. We have also developed a complementary technology for sensitive ultrasonic detection using resonant optical detectors. High-frequency ultrasound incident on these devices modulates the resonance condition and alters the intensity of a continuous wave (CW) laser beam probing the structure. The fundamental hypothesis of this proposal is that these technologies will produce very small, all-optical ultrasonic transducers enabling high spatial resolution imaging. Therefore, the primary goal of the research program described in this application is to develop a new intravascular imaging technology embedding a miniature, high-resolution ultrasonic imaging array within the tip of a guidewire used to deliver therapeutic catheters (typically 0.35 mm in diameter). A guidewire-based ultrasonic bio-microscopy (UBM) system would combine high resolution ultrasound imaging with conventional X-ray fluoroscopy in the baseline catheterization system. A wide range of technical and scientific issues must be investigated to fully exploit the capabilities of optoacoustic transduction. Therefore, it is the further aim of this application to address the following issues. 1.) Optimize optically absorbing polymer structures for efficient ultrasonic generation from 1-100 MHz. Particular emphasis will be placed on constructing optoacoustic transducers that can operate as arrays at these frequencies. 2.) Optimize polymer etalons for sensitive optical detection of ultrasound from 1-100 MHz. Particular emphasis will be placed on constructing etalons that can operate as arrays over these frequencies. 3.) Design, construct, and optimize a single element optoacoustic microscopy transducer. This device will serve as a test vehicle for all-optical ultrasonic transducers. In addition, it will be integrated into a high-performance UBM system for ophthalmology and dermatology applications. 4.) Design, construct, and optimize an all-optical, high-frequency ultrasonic array for UBM. This device will serve as a test vehicle for optical integration technologies. In addition, it will represent a significant advance for UBM by enabling real-time 3-D imaging. 5.) Design, construct, and optimize an all-optical, high-frequency ultrasonic array with dimensions that can fit within a conventional guidewire to guide coronary artery interventions.

描述（由申请人提供）： 在过去的几年中，我们开发了一种技术，可以使用在薄聚合物膜中吸收的激光脉冲来光学地产生超声波。这种方法产生的超声波强度与压电对应物相当，并且对高频应用特别有吸引力。我们还开发了一种使用谐振光学检测器的敏感超声检测的互补技术。这些设备上的高频超声调节可调节共振条件，并改变连续波（CW）激光束的强度，以探测结构。 该提议的基本假设是这些技术将产生非常小的全光超声传感器，从而实现高空间分辨率成像。因此，本应用程序中描述的研究计划的主要目标是开发一种新的血管内成像技术，该技术将微型的高分辨率超声成像阵列嵌入用于提供治疗导管的指南尖端（通常为0.35 mm，直径为0.35 mm）。基于指南的超声生物显微镜（UBM）系统将在基线导管系统中将高分辨率超声成像与常规X射线荧光镜结合起来。 必须研究广泛的技术和科学问题，以充分利用光声转导的能力。因此，解决以下问题是本申请的进一步目的。 1.）优化从1-100 MHz的有效超声产生的光学吸收聚合物结构。将特别强调构造可以在这些频率下以阵列作用的光声传感器。 2.）优化聚合物等人，以对1-100 MHz的超声检测进行敏感的光学检测。将特别强调构建可以在这些频率上作为阵列操作的eTalons。 3.）设计，构造和优化单个元素光声显微镜传感器。该设备将用作全光超声传感器的测试工具。此外，它将集成到用于眼科和皮肤科应用的高性能UBM系统中。 4.）设计，构建和优化UBM的全频，高频超声阵列。该设备将用作光学集成技术的测试工具。此外，通过实现实时3-D成像，它将代表UBM的重大进步。 5.）设计，构造和优化具有尺寸的全频，高频超声阵列，可以适合传统的导丝，以指导冠状动脉干预。