Optoacoustic Transduction for High-Frequency Ultrasound

高频超声的光声转换

• 批准号: 6976723
• 负责人: Matthew O'Donnell
• 金额: $ 33.01万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6976723
• 关键词: bioimaging /biomedical imaging; cardiovascular imaging /visualization; catheterization; coronary artery; fiber optics; fluoroscopy; polymers; sound frequency; technology /technique development; three dimensional imaging /topography

DESCRIPTION (provided by applicant): Over the last several years we have developed a technology to optically generate ultrasound using laser pulses absorbed in thin polymer films. This approach produces ultrasonic intensity comparable to piezoelectric counterparts and is especially attractive for high-frequency applications. We have also developed a complementary technology for sensitive ultrasonic detection using resonant optical detectors. High-frequency ultrasound incident on these devices modulates the resonance condition and alters the intensity of a continuous wave (CW) laser beam probing the structure. The fundamental hypothesis of this proposal is that these technologies will produce very small, all-optical ultrasonic transducers enabling high spatial resolution imaging. Therefore, the primary goal of the research program described in this application is to develop a new intravascular imaging technology embedding a miniature, high-resolution ultrasonic imaging array within the tip of a guidewire used to deliver therapeutic catheters (typically 0.35 mm in diameter). A guidewire-based ultrasonic bio-microscopy (UBM) system would combine high resolution ultrasound imaging with conventional X-ray fluoroscopy in the baseline catheterization system. A wide range of technical and scientific issues must be investigated to fully exploit the capabilities of optoacoustic transduction. Therefore, it is the further aim of this application to address the following issues. 1.) Optimize optically absorbing polymer structures for efficient ultrasonic generation from 1-100 MHz. Particular emphasis will be placed on constructing optoacoustic transducers that can operate as arrays at these frequencies. 2.) Optimize polymer etalons for sensitive optical detection of ultrasound from 1-100 MHz. Particular emphasis will be placed on constructing etalons that can operate as arrays over these frequencies. 3.) Design, construct, and optimize a single element optoacoustic microscopy transducer. This device will serve as a test vehicle for all-optical ultrasonic transducers. In addition, it will be integrated into a high-performance UBM system for ophthalmology and dermatology applications. 4.) Design, construct, and optimize an all-optical, high-frequency ultrasonic array for UBM. This device will serve as a test vehicle for optical integration technologies. In addition, it will represent a significant advance for UBM by enabling real-time 3-D imaging. 5.) Design, construct, and optimize an all-optical, high-frequency ultrasonic array with dimensions that can fit within a conventional guidewire to guide coronary artery interventions.

描述（由申请人提供）： 在过去的几年里，我们开发了一种利用聚合物薄膜吸收的激光脉冲以光学方式产生超声波的技术。这种方法产生的超声波强度与压电同类产品相当，对于高频应用特别有吸引力。我们还开发了一种使用谐振光学探测器进行灵敏超声波检测的补充技术。入射到这些设备上的高频超声波会调制共振条件并改变探测结构的连续波 (CW) 激光束的强度。 该提案的基本假设是，这些技术将产生非常小的全光学超声换能器，从而实现高空间分辨率成像。因此，本申请中描述的研究计划的主要目标是开发一种新的血管内成像技术，在用于输送治疗导管（通常直径为 0.35 毫米）的导丝尖端内嵌入微型高分辨率超声成像阵列。基于导丝的超声生物显微镜 (UBM) 系统将高分辨率超声成像与基线导管系统中的传统 X 射线透视相结合。 必须研究广泛的技术和科学问题，以充分利用光声传导的能力。因此，本申请的进一步目的是解决以下问题。 1.) 优化光学吸收聚合物结构，以有效产生 1-100 MHz 的超声波。将特别强调构建可以在这些频率下作为阵列运行的光声换能器。 2.) 优化聚合物标准具，以实现 1-100 MHz 超声波的灵敏光学检测。将特别强调构建可以在这些频率上作为阵列运行的标准具。 3.) 设计、构建和优化单元件光声显微镜换能器。该设备将作为全光学超声换能器的测试工具。此外，它将集成到眼科和皮肤科应用的高性能 UBM 系统中。 4.) 设计、构建和优化 UBM 全光学高频超声阵列。该设备将作为光集成技术的测试工具。此外，它还通过实现实时 3D 成像代表了 UBM 的重大进步。 5.) 设计、构建和优化全光学高频超声阵列，其尺寸适合传统导丝以引导冠状动脉介入治疗。