Elucidating perifoveal vascular development in infants

阐明婴儿中心凹周围血管发育

• 批准号: 10696178
• 负责人: Xi Chen
• 金额: $ 39.89万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10696178
• 关键词: 3-Dimensional; Adult; Age; Anastomosis - action; Angiography; Animal Model; Biomedical Engineering; Blindness; Blood Vessels; Blood capillaries; Child; Childhood; Complex; Cone; Data; Development; Devices; Disease; Early Diagnosis; Elderly; Etiology; Exhibits; Functional disorder; Fundus; Gestational Age; Goals; Human; Image; Imaging Techniques; Impairment; Individual; Infant; Infant Development; Knowledge; Location; Methods; Neurologic; Ophthalmologist; Optical Coherence Tomography; Pathology; Pattern; Photoreceptors; Pigmentation physiologic function; Pregnancy; Premature Birth; Premature Infant; Prevalence; Process; Recording of previous events; Research; Retina; Retinopathy of Prematurity; Sampling; Source; Speed; System; Three-dimensional analysis; Translations; Vascular Diseases; Vascularization; Vision; Visual; Visual Acuity; Visual impairment; Visualization; Work; density; disability; disorder of macula of retina; fovea centralis; imaging system; improved; in vivo; insight; longitudinal analysis; macular edema; multidisciplinary; premature

PROJECT SUMMARY One out of every ten infants is born preterm. Preterm birth can cause retinopathy of prematurity (ROP), a leading cause of childhood blindness. Even in the absence of ROP or neurological disability, children born preterm exhibit subtle impairments in visual acuity and visual function, though the etiology of this suboptimal vision in preterm infants remains unclear. The fovea, an indentation in the central retina, is the most critical region determining visual acuity. The fovea is surrounded by anastomosis of three layers of capillaries, forming the foveal avascular zone. It is well-established that children and adults with history of prematurity have a small or absent foveal avascular zone, retained foveal inner retinal layers, and decreased photoreceptor function, and that these abnormalities are more severe in individuals with history of treated ROP. The development of human perifoveal vasculature, however, is difficult to study due to the absence of fovea in most easily accessible animal models and the rarity of human histopathological samples during late gestation. Our multidisciplinary team with complementary expertise will work together to use advanced bedside handheld optical coherence tomography (OCT) angiography imaging to fill the gap in our knowledge of perifoveal vascular development in infants. We propose to elucidate the human perifoveal vascular development through the following specific aims: 1) optimize bedside handheld infant OCT angiography to visualize perifoveal vascular development; 2) determine if perifoveal vascular development is delayed in preterm infants compared to term infants, further delayed in ROP, and associates with poor outer retinal maturation; and 3) determine the association of macular edema and decreased perifoveal deep vascular complex formation and outer retinal maturation in preterm infants. This research will expand our knowledge of human foveal development and inform the pathophysiology of diseases of macular and retinal vascular development.

项目摘要 每10名婴儿中有一个是早产。早产会导致预性预期（ROP），一个 儿童失明的主要原因。即使在没有ROP或神经残疾的情况下，孩子出生 早产在视力和视觉功能方面表现出细微的障碍，尽管这种次优的病因 早产儿的视力尚不清楚。中央凹是中央视网膜中的凹痕，是最关键的 确定视力的区域。中央凹被三层毛细血管的吻合所包围，形成 凹起的血管区。有一个公认的是，有早产史的儿童和成年人很小 或不存在凹起的无血管区，保留的中央凹内视网膜层和降低感光体功能， 并且这些异常在患有治疗ROP史的个体中更为严重。发展的发展 然而，由于最容易没有中央凹的人，人类perifoveal脉管系统很难研究 妊娠晚期，可访问的动物模型和人类组织病理学样本的稀有性。 我们具有互补专业知识的多学科团队将共同使用高级床头手持 光学相干断层扫描（OCT）血管造影成像，以填补我们对perifoveal的知识的空白 婴儿的血管发育。我们建议通过 以下特定目的：1）优化床头手持式婴儿OCT血管造影以可视化perifoveal 血管发育； 2）确定比较早产儿的perifoveal血管发育是否延迟 为期婴儿，ROP进一步延迟，并且与视网膜外成熟不良相关； 3）确定 黄斑水肿的关联和呈perifoveal深血管复合物形成和视网膜外部的关联 早产婴儿的成熟。这项研究将扩大我们对人类中央凹发展的了解和 告知黄斑和视网膜血管发育疾病的病理生理学。