Core A: Administrative Core

核心A：行政核心

• 批准号: 10670332
• 负责人: Lennart Mucke
• 金额: $ 17.36万
• 依托单位: J. DAVID GLADSTONE INSTITUTES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670332
• 关键词: Accountability; Address; Advisory Committees; Alzheimer' s Disease; Applications Grants; Appointment; Bioinformatics; Collaborations; Communities; Data; Development; Ensure; Etiology; Faculty; Feedback; Goals; Growth; International; Joints; Lead; Leadership; Neurology; Positioning Attribute; Postdoctoral Fellow; Procedures; Program Reviews; Progress Reports; Publications; Reagent; Research; Research Activity; Research Personnel; Resources; Role; Safety; Services; Surveys; Training Programs; cost effectiveness; experience; graduate student; interest; meetings; member; nervous system disorder; network dysfunction; neural network; program dissemination; programs; recruit; senior faculty; technology development

CORE A – SUMMARY The Administrative Core (Core A) will oversee and coordinate all administrative and research activities within this program. All project leaders have primary faculty appointments in the Gladstone Institute of Neurological Disease (GIND), which Dr. Mucke has directed since its inauguration in 1998. His leadership of this institute, joint appointments in the Department of Neurology and various graduate training programs at UCSF, and long record of service on relevant national and international advisory committees put him in an excellent position to lead this core. He has collaborated with Drs. Yadong Huang (Project 1) and Jorge Palop (Project 2) on Alzheimer’s disease (AD) research for roughly two decades, as highlighted by many widely cited, coauthored publications in this field, and recently recruited Dr. Ryan Corces (Project 3 and Core B) to Gladstone and UCSF. For many years, he has also interacted closely with Drs. Katie Pollard and Alex Pico (Core B) through their leadership roles in Gladstone’s Bioinformatics Core. The well-established relationships among project and core leaders will greatly help Core A to accomplish its overall goal of overseeing, coordinating, and supporting studies proposed in all projects and cores. This program project will focus squarely on AD and places great emphasis on cohesiveness and collaborative interactions among projects. Core A will critically support and enforce these features and help ensure that our program not only addresses truly important biomedical problems, but also creates diverse opportunities for scientific growth and advancement in AD-relevant research for all of its members, ranging from graduate students and postdoctoral fellows to junior and senior faculty. Specifically, Core A will develop and implement program-wide procedures to ensure optimal levels of scientific rigor, data safety, cost effectiveness, and accountability across all four projects and the scientific core; encourage and facilitate collaborative interactions among all project and core leaders as well as between program members and other groups with related interests at Gladstone, UCSF, and beyond; survey relevant resources and fields of research and alert project and core leaders to conceptual or technological developments that could enhance the pursuit of their specific aims; form an external advisory committee and arrange regular meetings to review the program and provide constructive feedback to all project and core leaders; prepare progress reports; coordinate publications among program members; and collaborate with Core B to ensure the efficient dissemination of program-generated data, reagents, and research findings to the broader scientific community.

核心 A – 总结 行政核心（核心 A）将监督和协调内部的所有行政和研究活动 该项目的所有负责人均在格拉德斯通神经病学研究所担任主要教员。 疾病 (GIND)，自 1998 年成立以来，Mucke 博士一直负责该研究所的领导。 神经病学系和加州大学旧金山分校各种研究生培训项目的联合任命，以及长期 在相关国家和国际咨询委员会的服务记录使他处于有利地位 他与黄亚东博士（项目 1）和豪尔赫·帕洛普（项目 2）合作。 正如许多被广泛引用、共同撰写的文章所强调的那样，阿尔茨海默病 (AD) 研究已有大约二十年的历史 该领域的出版物，并且最近招募了 Ryan Corces 博士（项目 3 和核心 B）到 Gladstone 和 UCSF。 多年来，他还通过 Katie Pollard 博士和 Alex Pico（核心 B）博士进行了密切互动。 格莱斯顿生物信息学核心中的领导角色项目和核心之间建立了良好的关系。 领导者将极大地帮助核心 A 实现其监督、协调和支持研究的总体目标 在所有项目和核心中提出的该计划项目将直接关注 AD 并高度重视。 核心 A 将严格支持和执行这些项目之间的凝聚力和协作互动。 功能并帮助确保我们的计划不仅解决真正重要的生物医学问题，而且 为 AD 相关研究的科学发展和进步创造了多样化的机会 成员包括从研究生、博士后到初级和高级教师。 A 将制定并实施整个计划的程序，以确保科学严谨性、数据安全性的最佳水平， 所有四个项目和科学核心的成本效益和问责制；鼓励和促进 所有项目和核心领导者之间以及计划成员和其他人之间的协作互动 格莱斯顿、加州大学旧金山分校等机构有相关兴趣的小组调查相关资源和研究领域； 并提醒项目和核心领导者注意可以增强追求的概念或技术发展 他们的具体目标；组建外部咨询委员会并安排定期会议来审查该计划 并向所有项目和核心领导者提供建设性反馈；准备进度报告； 项目成员之间的出版物；并与核心 B 合作，确保有效传播 项目生成的数据、试剂和研究成果向更广泛的科学界提供。