Core A: Administrative Core

核心A：行政核心

• 批准号: 10461840
• 负责人: Lennart Mucke
• 金额: $ 19.84万
• 依托单位: J. DAVID GLADSTONE INSTITUTES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10461840
• 关键词: Accountability; Address; Advisory Committees; Alzheimer' s Disease; Applications Grants; Appointment; Bioinformatics; Communities; Data; Development; Ensure; Etiology; Faculty; Feedback; Goals; Growth; Institutes; International; Joints; Lead; Leadership; Neurology; Positioning Attribute; Postdoctoral Fellow; Procedures; Program Reviews; Progress Reports; Publications; Reagent; Research; Research Activity; Research Personnel; Resources; Role; Safety; Services; Surveys; Training Programs; cohesion; cost effectiveness; experience; graduate student; interest; meetings; member; nervous system disorder; network dysfunction; neural network; program dissemination; programs; recruit; senior faculty

CORE A – SUMMARY The Administrative Core (Core A) will oversee and coordinate all administrative and research activities within this program. All project leaders have primary faculty appointments in the Gladstone Institute of Neurological Disease (GIND), which Dr. Mucke has directed since its inauguration in 1998. His leadership of this institute, joint appointments in the Department of Neurology and various graduate training programs at UCSF, and long record of service on relevant national and international advisory committees put him in an excellent position to lead this core. He has collaborated with Drs. Yadong Huang (Project 1) and Jorge Palop (Project 2) on Alzheimer’s disease (AD) research for roughly two decades, as highlighted by many widely cited, coauthored publications in this field, and recently recruited Dr. Ryan Corces (Project 3 and Core B) to Gladstone and UCSF. For many years, he has also interacted closely with Drs. Katie Pollard and Alex Pico (Core B) through their leadership roles in Gladstone’s Bioinformatics Core. The well-established relationships among project and core leaders will greatly help Core A to accomplish its overall goal of overseeing, coordinating, and supporting studies proposed in all projects and cores. This program project will focus squarely on AD and places great emphasis on cohesiveness and collaborative interactions among projects. Core A will critically support and enforce these features and help ensure that our program not only addresses truly important biomedical problems, but also creates diverse opportunities for scientific growth and advancement in AD-relevant research for all of its members, ranging from graduate students and postdoctoral fellows to junior and senior faculty. Specifically, Core A will develop and implement program-wide procedures to ensure optimal levels of scientific rigor, data safety, cost effectiveness, and accountability across all four projects and the scientific core; encourage and facilitate collaborative interactions among all project and core leaders as well as between program members and other groups with related interests at Gladstone, UCSF, and beyond; survey relevant resources and fields of research and alert project and core leaders to conceptual or technological developments that could enhance the pursuit of their specific aims; form an external advisory committee and arrange regular meetings to review the program and provide constructive feedback to all project and core leaders; prepare progress reports; coordinate publications among program members; and collaborate with Core B to ensure the efficient dissemination of program-generated data, reagents, and research findings to the broader scientific community.

核心A - 总结 行政核心（核心A）将监督和协调所有行政和研究活动 这个程序。所有项目领导者都在格拉德斯通神经学院任命主要教师 自1998年就职典礼以来，穆克克（Mucke）的疾病（GIND）。 神经病学系和UCSF的各种研究生培训计划的联合任命，以及长期 相关国家和国际顾问委员会的服务记录使他处于极好的位置 领导这个核心。他与Drs合作。 Yadong Huang（项目1）和Jorge Palop（项目2） 阿尔茨海默氏病（AD）研究大约二十年，许多被广泛引用的人突出了 该领域的出版物，最近将Ryan Corces博士（项目3和B）招募到Gladstone和UCSF。 多年来，他还与Drs紧密互动。 Katie Pollard和Alex Pico（核心B）通过他们的 在Gladstone的生物信息学核心中的领导角色。项目和核心之间建立了良好的关系 领导者将极大地帮助核心A实现其监督，协调和支持研究的总体目标 在所有项目和核心中提议。该计划项目将直接关注广告，并重点放大 关于项目之间的凝聚力和协作互动。核心A将批判性支持并执行这些 功能并有助于确保我们的计划不仅解决了真正重要的生物医学问题，还可以解决 为科学增长创造了潜水员的机会，并在其所有与广告相关的研究中为其发展提供了机会 成员，从研究生和博士后研究员到初级和高级教师。具体来说，核心 一个将制定和实施整个程序的程序，以确保科学严谨的最佳水平，数据安全， 成本效益和所有四个项目和科学核心的问责制；鼓励和促进 所有项目和核心领导者以及计划成员与其他项目之间的协作互动 在Gladstone，UCSF及其他地区具有相关兴趣的团体；调查相关资源和研究领域 警报项目和核心领导者可以概念或技术发展，以增强追求 他们的具体目标；组成外部咨询委员会和安排定期会议，以审查该计划 并向所有项目和核心领导者提供建设性的反馈；准备进度报告；协调 计划成员的出版物；并与核心B合作，以确保有效传播 为更广泛的科学界提供了程序生成的数据，试剂和研究结果。