A Technology Resource for Polymer Microelectrode Arrays

聚合物微电极阵列的技术资源

基本信息

批准号：
10669205
负责人：
Ellis Meng
金额：
$ 122.54万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-30 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10669205
关键词：
Acceleration Address Adoption BRAIN initiative Behavioral Brain Chronic Clinical Communities Custom Data Devices Diameter Documentation Electrodes Electrophysiology (science)Ensure Evaluation FDA approved Feedback Goals Grant Histology Imaging technology Implant Masks Mechanics Metals Methodology Microelectrodes Modeling Monitor Neurosciences Neurosciences Research Operative Surgical Procedures Outcome Penetration Performance Polymers Printed Media Process Property Quality Control Rattus Recording of previous events Reproducibility Research Research Personnel Resources Running Semiconductors Services Silicon Site Specific qualifier value Surface Surface Properties Techniques Technology Testing Time Tissues Training Training Activity Vertebral column Work base cost density design digital media experimental study fabrication flexibility high standard implantation in vivo instructor integrated circuit interest medical implant meetings metal oxide nervous system disorder neural neuroprosthesis neurotechnology next generation optical imaging optogenetics parylene parylene C prototype quality assurance symposium testing services translational neuroscience web site

项目摘要

The purpose of this proposal is to disseminate polymer microelectrode arrays and promote their integrated into neuroscience research practice. Such polymer neural interfaces are mechanically compliant to promote stability of the device-tissue interface and versatile in that both surface and penetrating electrode arrays can be produced with the same technology. To accomplish their dissemination and integration, a resource will be created that offers the ability to customize electrode designs for their applications that are compatible with other recording and stimulation technologies and imaging technologies. The state-of-the-art polymer probes with high channel count will be made available to select users through project proposals selected with the input of a steering committee and to the broader community as prototypes on shared multi-project processing runs. Importantly, devices produced through user engagement will be functionally tested and ready to implant. The multi-project wafer processing runs will allow for small numbers of custom devices from multiple users to be produced on a single mask set which will allow users to debug and perform design adjustments and allow the resource to efficiently utilize wafer real estate. The resource also offers a testing service to validate electrode arrays made by external users. The successful in vivo implementation of interface technologies is dependent of their repeatable construction and reliable performance; these may be difficult to attain in small batch prototypes and even in commercially produced devices because of lack of testing capabilities or expertise. Device testing services will ensure rigor, reproducibility, and transparency for the benefit of the user community. The testing approach will be comprehensive, beginning at the materials level and progressing to the interface, interconnections, and packaging. Testing will include techniques that examine surface properties, material properties, mechanical performance, electrical and electrochemical performance, and lifetime testing. As needed, testing will be tailored for each project as dictated by its end use requirements. The testing methodologies will be rigorously documented and also disseminated. To facilitate adoption of technologies by users, the resource will offer onsite training on how to implement electrode arrays in vivo in rat. The resource seeks to enable BRAIN Initiative investigators and the broader community to achieve large scale recordings that will impact fundamental neuroscience research and next generation neuroprosthetic platforms for the treatment of multiple neurological disorders and conditions.

该提案的目的是传播聚合物微电极阵列并促进其整合到神经科学研究实践中。这种聚合物神经界面是机械的合规，以促进设备组织界面的稳定性和在表面上的多功能穿透电极阵列可以使用相同的技术生产。完成他们的传播和集成，将创建一个资源，以提供自定义电极的能力与其他录制和刺激技术兼容的应用程序的设计成像技术。将提供具有高通道计数的最先进的聚合物探针通过指导委员会的投入和更广泛的项目选择，通过项目提案选择用户社区作为共享多项目处理的原型运行。重要的是，通过用户参与将在功能上测试并准备植入。多项目晶圆处理运行将允许在单个掩码集中生产多个用户的少量自定义设备这将允许用户调试和执行设计调整，并允许资源有效利用晶圆房地产。资源还提供了测试服务，以验证外部用户制造的电极阵列。这成功的体内实施接口技术取决于其可重复的结构和可靠的性能；这些可能很难在小批次原型中获得由于缺乏测试功能或专业知识，商业生产的设备。设备测试服务将确保对用户社区的利益确保严格，可重复性和透明度。测试方法将是全面的，从材料级别开始，然后发展到界面，互连和包装。测试将包括检查表面特性，材料的技术特性，机械性能，电化学性能以及寿命测试。作为需要，根据其最终使用要求的决定，将对每个项目进行测试。测试方法学将被严格记录并传播。为了促进用户采用技术，资源将提供有关如何的现场培训在大鼠中实现体内电极阵列。该资源旨在使大脑倡议调查人员和更广泛的社区获得大规模记录，将影响基本的神经科学用于治疗多种神经系统疾病的研究和下一代神经假体平台和条件。