HORNET Center for Autonomic Nerve Recording and Stimulation Systems (CARSS)

HORNET 自主神经记录和刺激系统中心 (CARSS)

基本信息

批准号：
10557005
负责人：
Ellis Meng
金额：
$ 48.77万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-23 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10557005
关键词：
3-Dimensional Address Adopted Ally Architecture Autonomic nervous system disorders Biocontrols Caliber Clinical Complement Custom Electrodes Equilibrium Film Foreign Bodies Health Hypertension Immune response Implant Individual Inflammatory Bowel Diseases Lead Measures Medical Medicine Memory Metals Methods Microfabrication Molds Nerve Nerve Fibers Non-Insulin-Dependent Diabetes Mellitus Operative Surgical Procedures Perineuriums Peripheral Peripheral Nerves Peripheral Nervous System Polymers Process Recording of previous events Research Rheumatoid Arthritis Rotation Scheme Shapes Site Source Structure Surgical sutures System Technology Testing Thick Thinness Welding autonomic nerve base bioelectronics cost design flexibility instrument interest miniaturize minimally invasive novel open source parylene parylene C polydimethylsiloxane preservation tool wound

项目摘要

Implanted leads are critical for direct interfaces to the peripheral nervous system and have been used clinically since the 1960s. Even so, no open-architecture or open-source leads are available for autonomic nerve stimulation and recording. This is especially a problem for interfacing with soft, small diameter nerves measuring 1 mm or less. Since these are of great interest as targets in bioelectronic medicine, NEST 4 will introduce a new open-architecture nerve interface based on a helical cuff format. This cuff addresses the limitations of downscaling traditional materials and fabrication methods for polydimethylsiloxane-based cuffs and instead adopts a different scheme to achieve practical nerve cuffs using a composite Parylene C-PDMS structure. The CARSS helical microfabricated cuff uses soft polymers and thin film electrodes to achieve a miniaturized cuff form factor. The contra-rotational helical cuff design is achieved by post-processing the Parylene electrode array using a thermoforming process to achieve the final three-dimensional shape. The helical design is self- sizing and self-closing which avoids the need for sutures. The cuff is accompanied by a minimally invasive, custom endoscopic tool that will simplify surgery and allow access to deeper autonomic nerve branches. In NEST 4, the Parylene helical cuff will be developed, benchtop tested, and demonstrated with the surgical placement tool, paving the way for a widely accessible cuff for smaller nerves in clinical bioelectronic medicine research.

植入的导线对于直接接口到外周神经系统至关重要，并且已在临床上使用自1960年代以来。即便如此，没有开放式结构或开源线索可用于自主神经刺激和记录。这尤其是与测量柔软的小直径神经接口的问题 1毫米或更少。由于这些对生物电子医学的目标引起了极大的兴趣，因此Nest 4将引入一个新的基于螺旋袖带格式的开放结构神经界面。这个袖口解决了缩小基于聚二甲基硅氧烷的袖口的传统材料和制造方法，而是采用不同的方案，使用复合parylene c-PDMS结构实现实用的神经袖口。汽车螺旋微生物袖口使用软聚合物和薄膜电极来实现微型化袖口象形。通过后处理parylene电极，可以实现逆向旋转螺旋袖带设计阵列使用热成型工艺实现最终的三维形状。螺旋设计是自我的尺寸和自我关闭，避免了缝合线的需求。袖口伴随着微创，自定义内窥镜工具将简化手术并允许进入更深的自主神经分支。在Nest 4中，将开发甲状腺螺旋袖带，测试台式，并通过手术证明放置工具，为临床生物电子医学的较小神经铺平道路研究。