Bioinformatics and Biostatistics Core

生物信息学和生物统计学核心

• 批准号: 10664049
• 负责人: Tanika Nicole Kelly
• 金额: $ 16.65万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-10 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10664049
• 关键词: Acceleration; Address; Adopted; Bioinformatics; Biomedical Research; Biometry; Biostatistics Core; Cardiometabolic Disease; Centers of Research Excellence; Clinical; Clinical Research; Communities; Computational Technique; Core Facility; Data; Data Analyses; Data Set; Dedications; Educational workshop; Ensure; Fees; Funding; Funding Agency; Goals; Grant; Individual; Interdisciplinary Study; Manuscripts; Measures; Mentorship; Methodology; Methods; Molecular; Peer Review; Phase; Pilot Projects; Public Health Practice; Publishing; Quality Control; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Scientific Inquiry; Services; Statistical Data Interpretation; Technology; Training; Translating; Translational Research; United States National Institutes of Health; Universities; clinical care; complex biological systems; complex data; computer infrastructure; computing resources; data management; data quality; data structure; disorder prevention; empowerment; high dimensionality; multidimensional data; novel; programs; protocol development; randomized, clinical trials; research study; skills; success; tool; training opportunity

ABSTRACT (Bioinformatics and Biostatistics Core) The growing availability of large-scale, high-dimensional molecular information and clinical research data, as well as sophisticated statistical methodologies for analyzing these complex data, provides unprecedented opportunity to advance clinical and translational research of cardiometabolic disease. However, extensive study design, bioinformatics, biostatistics, and computational expertise is needed to appropriately incorporate these cutting-edge advancements into biomedical research. As part of the proposed Centers for Biomedical Research Excellence (COBRE) Phase 2 grant, we will establish a new Bioinformatics and Biostatistics Core (BBC) that will serve as a hub for study design, bioinformatics, biostatistics, and computational support. The overall objectives of the BBC are: 1.) To expand study design, bioinformatics, biostatistics, and computational resources, capacity, and support in the COBRE program through the establishment of a dedicated analytic and computational infrastructure; and 2.) To train and assist research project leaders (RPLs), pilot project leaders (PPLs), other COBRE investigators, and collaborators in the application of sophisticated bioinformatics and biostatistics approaches that promote high-quality research. To achieve these objectives, the BBC will provide RPLs, PPLs, other COBRE investigators, and collaborators with the support in study design, bioinformatics, and biostatistics that is needed to conduct high-quality clinical and translational research of cardiometabolic disease (Aim 1). Furthermore, we will leverage our expertise in bioinformatics and biostatistics to develop and implement novel tools and methods that are tailored to Research Projects of RPLs, PPLs, other COBRE investigators, and collaborators and may be adapted and adopted by the Tulane scientific community. As part of Aim 2, the BBC will provide training opportunities to RPLs, PPLs, other COBRE investigators, and collaborators seeking to broaden and enhance their clinical and translational research skills. Our proposed workshops and one-on-one mentorship opportunities will build bioinformatics, biostatistics, and computational research skills, empowering COBRE investigators and collaborators to independently conduct rigorous clinical and translational research in cardiometabolic disease. To ensure continued visibility and utilization of the BBC beyond the COBRE funding period, we will also establish a self-sustaining BBC that will serve as a long-term resource for the Tulane University scientific community (Aim 3). Our self-sustaining core facility will be supported by NIH-funded research studies, as well as fee-based services for non-COBRE investigators. In total, the BBC is a critical component of the COBRE Phase 2 program, which will be extensively utilized by all four proposed COBRE Research and Pilot Projects. The BBC will provide Tulane investigators with the supports necessary to accelerate scientific discovery and translate those discoveries to public health practice and clinical care in cardiometabolic disease.

摘要（生物信息学和生物统计学核心） 大规模，高维分子信息和临床研究数据的可用性不断增长 以及用于分析这些复杂数据的复杂统计方法，提供了前所未有的 推进心脏代谢疾病的临床和转化研究的机会。但是，广泛 需要适当合并研究设计，生物信息学，生物统计学和计算专业知识 这些尖端的进步是生物医学研究的。作为拟议生物医学中心的一部分 研究卓越（COBRE）第2阶段赠款，我们将建立新的生物信息学和生物统计学 核心（BBC）将作为研究设计，生物信息学，生物统计学和计算支持的枢纽。 英国广播公司的总体目标是：1。）扩展研究设计，生物信息学，生物统计学和 通过成立 专用的分析和计算基础架构；和2.）培训和协助研究项目负责人 （RPLS），飞行员项目负责人（PPLS），其他毛病调查员以及适用的合作者 促进高质量研究的复杂生物信息学和生物统计学方法。实现这些 目标，英国广播公司将提供RPLS，PPLS，其他毛绒调查员和合作者的支持 进行高质量临床和翻译所需的研究设计，生物信息学和生物统计学 心脏代谢疾病的研究（AIM 1）。此外，我们将利用我们在生物信息学上的专业知识 生物统计学开发和实施针对RPLS研究项目量身定制的新颖工具和方法， PPLS，其他毛绒调查员和合作者，可能会被图兰科科学的调整和采用 社区。作为AIM 2的一部分，英国广播公司将为RPL，PPLS，其他毛绒提供培训机会 调查人员以及寻求扩大和增强其临床和转化研究技能的合作者。 我们提议的研讨会和一对一的指导机会将建立生物信息学，生物统计学和 计算研究技能，授权山羊研究人员和合作者独立进行 心脏代谢疾病的严格临床和转化研究。确保持续的知名度和 BBC的利用超过了山毛的资金期，我们还将建立一个自我维持的BBC 作为杜兰大学科学界的长期资源（AIM 3）。我们自我维持的核心 NIH资助的研究将支持设施，以及非近代的收费服务 调查人员。总的来说，英国广播公司是COBRE 2阶段计划的关键组成部分，这将是 所有四个拟议的毛病研究和试点项目都广泛使用。英国广播公司将提供图兰 具有加速科学发现并将这些发现转化为必要的支持的调查员 心脏代谢疾病中的公共卫生实践和临床护理。