Bioinformatics and Biostatistics Core

生物信息学和生物统计学核心

基本信息

批准号：
10504811
负责人：
Tanika Nicole Kelly
金额：
$ 16.63万
依托单位：
TULANE UNIVERSITY OF LOUISIANA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-03-10 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10504811
关键词：
Address Adopted Bioinformatics Biomedical Research Biometry Biostatistics Core Cardiometabolic Disease Centers of Research Excellence Clinical Clinical Research Communities Computational Technique Core Facility Data Data Analyses Data Set Educational workshop Ensure Fees Funding Funding Agency Goals Grant Individual Institutes Interdisciplinary Study Manuscripts Measures Mentorship Methodology Methods Molecular Peer Review Phase Pilot Projects Public Health Practice Publishing Quality Control Randomized Clinical Trials Research Research Design Research Infrastructure Research Personnel Research Project Grants Resources Scientific Inquiry Services Statistical Data Interpretation Technology Training Translating Translational Research United States National Institutes of Health Universities base clinical care complex biological systems complex data computer infrastructure computing resources data management data quality data structure disorder prevention empowered high dimensionality multidimensional data novel programs protocol development research study skills success tool training opportunity

项目摘要

ABSTRACT (Bioinformatics and Biostatistics Core) The growing availability of large-scale, high-dimensional molecular information and clinical research data, as well as sophisticated statistical methodologies for analyzing these complex data, provides unprecedented opportunity to advance clinical and translational research of cardiometabolic disease. However, extensive study design, bioinformatics, biostatistics, and computational expertise is needed to appropriately incorporate these cutting-edge advancements into biomedical research. As part of the proposed Centers for Biomedical Research Excellence (COBRE) Phase 2 grant, we will establish a new Bioinformatics and Biostatistics Core (BBC) that will serve as a hub for study design, bioinformatics, biostatistics, and computational support. The overall objectives of the BBC are: 1.) To expand study design, bioinformatics, biostatistics, and computational resources, capacity, and support in the COBRE program through the establishment of a dedicated analytic and computational infrastructure; and 2.) To train and assist research project leaders (RPLs), pilot project leaders (PPLs), other COBRE investigators, and collaborators in the application of sophisticated bioinformatics and biostatistics approaches that promote high-quality research. To achieve these objectives, the BBC will provide RPLs, PPLs, other COBRE investigators, and collaborators with the support in study design, bioinformatics, and biostatistics that is needed to conduct high-quality clinical and translational research of cardiometabolic disease (Aim 1). Furthermore, we will leverage our expertise in bioinformatics and biostatistics to develop and implement novel tools and methods that are tailored to Research Projects of RPLs, PPLs, other COBRE investigators, and collaborators and may be adapted and adopted by the Tulane scientific community. As part of Aim 2, the BBC will provide training opportunities to RPLs, PPLs, other COBRE investigators, and collaborators seeking to broaden and enhance their clinical and translational research skills. Our proposed workshops and one-on-one mentorship opportunities will build bioinformatics, biostatistics, and computational research skills, empowering COBRE investigators and collaborators to independently conduct rigorous clinical and translational research in cardiometabolic disease. To ensure continued visibility and utilization of the BBC beyond the COBRE funding period, we will also establish a self-sustaining BBC that will serve as a long-term resource for the Tulane University scientific community (Aim 3). Our self-sustaining core facility will be supported by NIH-funded research studies, as well as fee-based services for non-COBRE investigators. In total, the BBC is a critical component of the COBRE Phase 2 program, which will be extensively utilized by all four proposed COBRE Research and Pilot Projects. The BBC will provide Tulane investigators with the supports necessary to accelerate scientific discovery and translate those discoveries to public health practice and clinical care in cardiometabolic disease.

摘要（生物信息学和生物统计学核心）大规模、高维分子信息和临床研究数据的可用性不断增加，以及用于分析这些复杂数据的复杂统计方法，提供了前所未有的推进心脏代谢疾病临床和转化研究的机会。然而，广泛需要研究设计、生物信息学、生物统计学和计算专业知识来适当整合这些生物医学研究的前沿进展。作为拟议的生物医学中心的一部分研究卓越（COBRE）第二阶段资助，我们将建立一个新的生物信息学和生物统计学 Core (BBC) 将作为研究设计、生物信息学、生物统计学和计算支持的中心。 BBC 的总体目标是： 1.) 扩展研究设计、生物信息学、生物统计学和通过建立一个 COBRE 计划的计算资源、能力和支持专用的分析和计算基础设施； 2.) 培训和协助研究项目负责人 (RPL)、试点项目负责人 (PPL)、其他 COBRE 研究人员以及应用中的合作者促进高质量研究的复杂生物信息学和生物统计学方法。为了实现这些为了实现目标，BBC 将为 RPL、PPL、其他 COBRE 调查人员和合作者提供以下支持：进行高质量临床和转化所需的研究设计、生物信息学和生物统计学心脏代谢疾病的研究（目标1）。此外，我们将利用我们在生物信息学和生物统计学开发和实施适合 RPL 研究项目的新工具和方法， PPL、其他 COBRE 研究人员和合作者可能会被杜兰大学科研机构改编和采用社区。作为目标 2 的一部分，BBC 将为 RPL、PPL 和其他 COBRE 提供培训机会寻求扩大和提高临床和转化研究技能的研究人员和合作者。我们提议的研讨会和一对一指导机会将建立生物信息学、生物统计学和计算研究技能，使 COBRE 研究人员和合作者能够独立进行心脏代谢疾病方面严格的临床和转化研究。为了确保持续的可见性和为了在 COBRE 资助期限之外利用 BBC，我们还将建立一个自我维持的 BBC，作为杜兰大学科学界的长期资源（目标 3）。我们的自我维持核心该设施将得到 NIH 资助的研究以及针对非 COBRE 的收费服务的支持调查人员。总的来说，BBC 是 COBRE 第 2 阶段计划的重要组成部分，该计划将被所有四个拟议的 COBRE 研究和试点项目广泛使用。 BBC 将提供杜兰大学研究人员获得加速科学发现并将这些发现转化为必要的支持心脏代谢疾病的公共卫生实践和临床护理。